Most are organized simply by last name of primary author. If you should find a broken link, please let me know.
BOYLE 2011
BOZZETTO 2012
Note: The author discounts dietary change as "disappointing" without suggesting it be ruled out. He does not appear to consider 30 years of reports that while the Feingold diet "cures" many children's abdominal pain (and psychiatric disorder), those who don't get better on Feingold often do get better on a gluten-free/casein-free diet.
DINKEL 2004 (See SAPOLSKY 2004)
Final paragraph:
FDA: QB test (See Dolgin 2014)
================================
GIBSON 1978 (SEE SWAIN)
++++++++++++++++
Hinton 2000 - see Toxicology (Guidelines)
Note: It is the GABA neurons that are the "brakes" of the nervous system.
KENDALL 2008 -- see NICE
KLEINMAN re breastfeeding; see FEWTRELL 2007
There is another study, by Levitan, showing that the coloring in the blood is 99% bound to proteins and therefore cannot cross the blood brain barrier .... but that ignores the fact that this is exactly how psychoactive drugs work -- they are bound to the proteins, and leak across very slowly; that is why taking another drug sometimes potentiates a medication -- it knocks it off the proteins so that more leaks across the barrier faster. There are other studies showing that under stress, the blood brain barrier becomes more permeable and leaky .... and they showed it using blue dye. Do you want all these kinds of things too?
MICHAELI 1966 -- see FEINGOLD 1966
"Dietary advice
PERRY 2001 - See FDA Petition to delist Yellow 5
What they say about diet therapy - and please note that this is the information that the FDA uses today - 2009 - to justify their refusal to remove the food dyes from American products. Note the age of the studies cited, and the fact that they claim the Rowe & Rowe 1994 study showed "A small number of children may respond negatively to
tartrazine, a synthetic food dye." In that Rowe study, the percent of 200 children responding to diet was 75%. The percent of those reacting to a single dye challenge (and showing a dose-response) was 82.6% - how did this metamorphose into a "small number?" And one more thing ... don't miss the last sentence, in which they warn physicians not to "disrupt the therapeutic alliance." Now how condescending is that? Read it all for yourself here:
Quote from Practice Parameters 2007, p. 903:
SANDSTEAD 1956 -- See BING 1956
SERVANT 2010 -- see Senomyx
So we replace tomatoes with raw vegetables? We replace grapes with fresh fruit? Vegetables and fruits are limited by KIND, not by whether they are fresh, frozen or canned. Nor are whole grains required to do the Feingold diet, although it is great to use them. And .... what is a mineral soup anyhow? Oh - one more thing - salicylates are not in the artificial colors and flavors (well, maybe in some - who knows what is in the flavors?) But they are separate problems.
Negative review: Page 7: "Advocates of dietary modification for the management of behavioural problems in children, including ADHD, have been remarkably persistent, despite a lack of scientific evidence of acceptable quality." (continues, quoting other reviews, and MISquoting the NIH. Even by 2005, he should have known better.)
-- See also Bateman and McCann
SUGAR: See Appleton: 124 ways Sugar Can Ruin Your Health
UMEMURA -- see under BHT
UNIS 1997
WARING: See also HARRIS
Note: Wender is often quoted as the expert claiming that only 1% of children “demonstrated any consistent behavioral change in the expected direction.” However, she was not talking about 1% responding to the DIET, but rather 1% responding to the CHALLENGEs. Since the challenges were uniformly small, this is not very surprising. It is like using a baby aspirin in a study attempting to show aspirin useful for headache reduction in grown men.
ZHANG 2010 -- see Senomyx
Most of the full texts are in PDF Format. Some were scanned from paper copies and may take some time to open.
If you need an Acrobat Reader, you can get it here.
NOTE: Those studies not openly available on the Internet are in a password-protected file to protect their copyright. If the study you want is asking for a password, write me and I will be happy to send it to you.
-- see also PRACTICE PARAMETERS 1997 for more information
*ADHD
*Reported that the best selling keto pills has gained popularity for its health benefits like weight loss and increased energy increased focus and energy, and even as treatment to certain illnesses.
The occurrence of adverse drug reactions reported for attention deficit hyperactivity
disorder (ADHD) medications in the pediatric population: a qualitative review of empirical studies
*ADHD, medication side effects, drug reactions, Aagaard, Hansen
Allergic contact dermatitis from tertiary-butylhydroquinone (TBHQ) in a
vegetable hydraulic oil
*allergy, TBHQ, BHA, dermatitis, Finland
"Inactive" Ingredients in Pharmaceutical Products
American Academy of Pediatrics Committee on Drugs
*Food Dye, Color
"Inactive" Ingredients in Pharmaceutical Products: Update
American Academy Committee on Drugs
*Food Dye, Color
ADHD - Unproven Treatments
* Note that DIET is no longer listed as an "unproven treatment" ... well it's a far cry from being a recommended treatment, but maybe that will come in another 30 years?
Clinical Practice Guideline: Treatment of the School-Aged Child With
Attention-Deficit/Hyperactivity Disorder
* adhd,American Academy of Pediatrics
Grand Rounds - February 2008
"we ... admit we might have been wrong." [Full article]
*ADHD
Toxic effects of some synthetic food colorants and/or flavor additives on male rats
*Food dyes, flavors, rats, Abd El-Wahaab, Moram.
Effect of Long Term Intake of Aspartame on Antioxidant Defense Status in Liver
*Rats, Glutathione, alkaline phosphatase (ALP), alanine aminotransferase (ALT)
Oral Presentations relating to Multiple Sclerosis
Nutrition and Behavior: The legend continues (ridicules diet as treatment)
*adhd, food additives, opinion piece: "The parent who wants to engage in scientific debate about the harmfulness of food additives needs to be sent off to read the article by Shaywitz ..."
Tyrosine: Effects on Catecholamine Release
*Rats, Dopamine
Lack of behavioral effects from Feingold diet violations
* ADHD, diet. This is often quoted as one of the "negative" studies. I you add up the individual amounts of coloring that they list in Table 2 on Page 311, you will discover that they actually only add up to 18.8 mg and NOT the 26.3 mg total listed in the table.
Nutrition and its relationship to autism.
* tutorial, nutrition, candidiasis (yeast), gluten/casein intolerance, celiac disease, diet, vitamins, minerals. Case studies.
Workshop to identify critical windows of exposure for children's health: Neurobehavioral Work Group Summary
*developmental neurotoxicolgy, developmental disorders, behavior, Adams, Barone, LaMantia, Philen, Rice, Spear, Susser
Pilot Study of a Moderate Dose Multivitamin/Mineral Supplement
for Children with Autistic Spectrum Disorder
* Actually, B6 test before study looked like kids with autism are high in B6, but that is because they apparently
convert to active form slowly and are low in THAT.
* Good overview of a variety of other nutrients in autism. Adams & Holloway.
Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity
Effect of a vitamin/mineral supplement on children and adults with autism
* Improvement in methylation, glutathion, exidative stress, sulfation, ATP, NADH, NADPH.
* "...a vitamin/mineral supplement is a reasonable adjunct therapy to
consider for most children and adults with autism."
* Adams, Audhya, McDonough=Means, Rubin, Quig, Geis, Gehn, Loresto, Mitchell, Atwood, Barnhouse, Lee.
Restricted elimination diet for ADHD
*Criticism of Pelsser 2011
Changes in catecholamine excretion after short-term tyrosine ingestion in normally fed human subjects
*Tyrosine, Dopamine
Environmental lead toxicity and nutritional factors
* Lead exposure without food is more absorbed; range is from 10% to 80%.
* Influence lead effects: Food, calcium, zinc, beta-carotene, vitamin B6, vitamin E, vitamin C, selenium, iron
* Ahamed & Siddiqui. India.
Pulmonary intravascular macrophages as proinflammatory cells in heaves,
an asthma-like equine disease
* heaves, asthma, horse. Aharonson-Raz, Lohmann, Townsend, Marques, Singh. Canada.
Psychogenic and organic movement disorders in children
*Tourette Syndrome, ataxia, Ahmed, Martinez, Yee, Besag.
Induction of Apoptosis, Necrosis and differentiation in hepG2 cell line (Comparison between natural and
Synthetic products)
*Cancer, Tumors, TBHQ, Apoptosis, Malignancies
Therapeutic Potential and Anti-Amyloidosis Mechanisms of Tert-Butylhydroquinone for Alzheimer’s Disease
Alzheimer's disease, dementia, amyloid, brain, mice, TBHQ, glutathione, antioxidant, oxidative stress. China. Akhter, Katre, Li, Liu, Liu.
The Sensitivity of the Child to Sex Steroids: Possible Impact of
Exogenous Estrogens
*Cancer, hormones disruption, childhood, estradiol, steroids, estrogenic, Aksglaede, Juul, Leffers, Skakkebaek,
Andersson, Denmark
Blue toes after stimulant therapy for pediatric attention deficit hyperactivity disorder
*ADHD, Adderall, Stimulant Medication, Vascular Damage
Platelet sulphotransferase activity, plasma sulphate levels and sulphation capacity in patients with migraine and tension headache.
*PST, Waring, Sulphation, Sulfation
Sulphation deficit in "low-functioning" autistic children: a pilot study.
*PST, Waring, Sulphation, Sulfation, Paracetamol, Tylenol
Determination of Three Dyes in Commercial Soft Drinks Using HLA/GO and Liquid Chromatography.
*Red 40 Allura Red, Yellow 6 Sunset Yellow, Yellow 5 Tartrazine
An Outbreak of Illness Among Schoolchildren in
London: Toxic Poisoning Not Mass Hysteria
*Cucumbers, pesticide, Aldous, Ellam, Murray, Pike
Plasma Amino Acid Levels in Children with Autism and Their Families
* Autism, Asperger; patients & parents and siblings have elevated or reduced levels of some amino acids.
* Aldred, Moore, Fitzgerald, Waring.
Increased Prevalence of Asthma in Saudi Arabia
*Asthma in children increased from 8% in 1986 to 23% in 1995, Al Frayh, Shakoor, Gad El Rab, Hasnain. Saudi Arabia.
Snoring, Sleep Disturbance, and Behaviour in
4-5 year olds
*Children, sleep, smoking, hyperactive, aggression, Ali, Pitson, Stradling
Locomotor and Learning Deficits in Adult Rats Exposed to Monosodium-L-Glutamate During Early Life
*Rats, MSG, decreased learning, quote: "MSG treatment in young (weaned) rats induces subtle, long-lasting changes in the dopamine (DA) receptor status and/or DAergic neuronal pathways." Ali, Bawari, Misra, Babu. India.
MonoSodium Glutamate-induced Damage in Rabbit Retina: Electroretinographic and Histologic Studies
* MSG, glutamate. Lowest dose tested (1 g/kg) had adverse effects on rabbit retina.
* Higher dose showed extensive damage to retina.
* Ali, Ed-Gohary, Metwally, Sabra, Sayed. Egypt.
Adverse Reactions to Foods
*Allergy, food intolerance, pharmacological, asthma, MSG, urticaria, hives, salicylate, food, glutamate, nitrates, sorbic acid, benzoic acid, benzoates, colorings, colourings, dyes, sulphite, sulfite, amines, questionnaire, diet at RPAH, Australia, Allen, Van Nunen, Loblay, Clarke, Swain
Mental health of children with learning disabilities
- Note: "Parents themselves often impose a particular diet
in an attempt to improve the behavioural problems
of children with autistic-spectrum disorders.
Exclusion diets (particularly gluten and casein)
and supplements such as fish oils and vitamin B6
are common. The possible benefits of these dietary
manipulations have yet to be rigorously evaluated."
*Behavior, Sleep, ADHD, Self-Talk, Psychosis, Autism, Medications
Role of Hyperparathyroidism in the Management of Depression and Anxiety
The Prevalence of ADHD-Like Symptoms in a Community Sample - UK
* History, monograph, date estimate: after 2007
Diet restriction in migraine, based on IgG against foods: A clinical double-blind, randomised, cross-over trial
The Comorbidity of ADHD in the General Population of Saudi Arabian School-Age Children
*Oppositional-Defiant Disorder, ODD, Conduct Disorder, CD, Anxiety, Depression
Physiological Effect of a Food Additive on Some Haematological and Biochemical Parameters of Male Albino Rats
*Rats, food colors, food dyes, amaranth/Red 2, Egypt.
The Dietary Exposure Assessment to Selected Food Additives and Contaminants for the GCC Countries Population
FD&C; Blue Dye No. 1 and Blue Nail Discoloration: Case Report
*Blue 1, Brilliant Blue, Adverse Effects, Tube Feedings, Systemic Absorption
A patient's view of asthma
* written when asthma was still often thought to be psychosomatic, but a great description & a good story
Double-Blind, Placebo-Controlled Study of Risperidone for the Treatment of Disruptive Behaviors in Children With Subaverage Intelligence
*Retarded Children
Psychiatric Comorbidities in ADHD Children: An Iranian Study among Primary School Students
* phobia, ODD, tics, enuresis, bedwettingli
*Amphetamine, Cocaine, Stimulants, Benzedrine, Asthma, Narcolepsy, Depression, Hyperactivity, ADHD, Appetite Suppressant, Combat, Preludin, Ritalin, Crystal Meth
Biological Factors in Attention Deficit-Hyperactivity Disorder
*ADHD, review, neurological factors, brain damage, neurological dysfunction, under-reactivity to stimulation, toxic reactions - food dyes "very small percentage of children" ... quoted studies: Taylor 1979, Conners 1980, and Gross 1987, medication side effects - phenobarbital, dilantin. Anastopoulos, Barkley.
Feingold Diet
*Letter to editor re Breakey, environmental factors, hyperkinetic, quotes National Medical Health and Research Council June 1978, family environment, no proof.
Chronic obstructive pulmonary disease and long-term exposure to traffic-related air pollution:
a cohort study
*COPD, Nitrogen Dioxide, Denmark
Acute Toxic Effects of Fragrance Products
*Perfume, mice, mouse, sensory, pulmonary, lung, irritation, ASTM-E-981, airflow, nervous system, neurotoxicity, neurological testing, worse on repetition of exposure.
Exposure to Exogenous Estrogens in Food: Possible Impact on
Human Development and Health
*Environmental chemicals, hormone, estradiol, meat, Andersson, Skakkebaek
Association of Symptoms of Attention-Deficit/Hyperactivity Disorder with Physical Activity, Media Time, and Food Intake in Children and Adolescents
* ADHD, diet, TV. Andreas, Egmond-Frohlich, Weghuber, de Zwaan. Germany.
Thimerosal Exposure in Infants and Developmental Disorders: A Retrospective Cohort Study in the United Kingdom Does Not Support a Causal Association
*Autism, vaccines, mercury, thimerosal, Andrews, Miller, Grant, Stowe, Osborne, Taylor
Note: Taylor testified against Wakefield in Burton Congressional Hearings in 2000
- letter re Hill's complaint that diet is difficult
*ADHD, Diet, Omega 6, Zinc
Omega-3 fatty acids (fish-oil) and depression-related cognition in healthy volunteers
Modulation of GABA receptors expressed in Xenopus oocytes by 13-L-hydroxylinoleic acid and food additives.
*Tenpaku, Rats, Additives, Perfumes, Caffeine, Vanillin, Brain
Potentiation of GABAA receptors expressed in Xenopus oocytes by perfume and phytoncid.
*Rats, Brain
Effects of bisphenol A and its derivatives on the response of GABA(A) receptors expressed in Xenopus oocytes.
*Rats, BPA, Brain
Hyponatraemic Convulsion Secondary to
Desmopressin Treatment for Primary Enuresis
*Child, bedwetting, bed wetting, seizures, coma, water intoxication, nasal spray, Apakama, Bleetman
124 ways sugar can ruin your health
Presenting problems and assigned diagnoses among young Latino children with disruptive behavior
*Hyperactive, ADHD, Hyperactivity, Aggression, ODD
Fluorosis in India: an overview
* fluoride. India.
* It is referred to as a nutrient in this article. FluorideAlert.org disagrees and
provides scientific resources including CDC
Does Hair Zinc Predict Amphetamine Improvement of ADD/Hyperactivity?
*zinc deficiency, Arnold, Votolato.
Treatment alternatives for attention deficit hyperactivity disorder (ADHD)
Journal of Attention Disorders
Does Zinc Moderate Essential Fatty Acid and Amphetamine Treatment of Attention-Deficit/Hyperactivity Disorder?
*ADHD, zinc, efa, children, Efamol, evening primrose oil, GLA, d-amphetamine, Arnold, Pinkham, Votolato, review.
Zinc in Attention-Deficit/Hyperactivity Disorder
Zinc for Attention-Deficit/Hyperactivity Disorder: Placebo-Controlled Double-Blind Pilot Trial Alone
and Combined with Amphetamine
*ADHD, zinc, larger doses needed, Arnold, DiSilvestro, Bozzolo, Crowl, Fernandez, Remadan, Thompson, Mo, Sbdel-Rasoul, Joseph
Artificial Food Colors and Attention-Deficit/Hyperactivity
Symptoms: Conclusions to Dye for
* ADHD, food dye, FDA
Minor Physical Anomalies and Family Adversity
as Risk Factors for Violent Delinquency in Adolescence
Food Allergen Avoidance in Primary Prevention of Food Allergy
*Children, prophylactic allergen avoidance, atopy, atopic disorders, urticaria, hives, asthma, breastfeeding, hydrolysed formula, hydrolysate, peanut, egg, additives not discussed.
Primary Prevention of Asthma and Atopy During Childhood by Allergen Avoidance in Infancy: A Randomised Controlled Study
*Children, asthma, atopy, atopic, house dust mite, allergen, allergic, prophylactic, breastfeeding, Arshad, Bateman, Matthews, UK.
An Examination of Shared Variance in Self-Report and Objective Measures of Attention in the Incarcerated Adult Population
Multiple Intolerance to Food Additives
*Letter to editor, behavior, allergy, double blind challenge study, BHA, sodium metabisulfite, MSG, monosodium glutamate
Synergistic effects of food colors on the toxicity of 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) in primary cultured rat hepatocytes.
Bronchoconstrictor additives in
bronchodilator solutions.
Pulmonary function response to EDTA,
an additive in nebulized bronchodilators.
EFSA: REPORT OF THE MEETINGS ON ASPARTAME WITH NATIONAL EXPERTS 2009
Plasma and Erythrocyte Fatty Acid Patterns in Patients with Recurrent Depression: A Matched Case-Control Study
* Reducing asthma from a disease to a symptomershoff
Misbehaviour in British and Turkish Primary Classrooms
* comparison of Turkish & British classroom behavior, expectations, etc.
Mitigating effects of the adoptive caregiving environment on inattention/overactivity in children adopted from Romanian orphanages
* Indicates that care-giving certainly does impact ADHD ... so much for statements that "bad parenting" is not at fault
Neurotransmitter release from a vertebrate neuromuscular synapse affected by a food dye.
Neurotransmitter release and nerve terminal morphology at the frog neuromuscular junction affected by the dye Erythrosin B
Presynaptic effect of Erythrosin B at the frog neuromuscular junction: ion and photon sensitivity.
Language and Focal Brain Lesion in Childhood
Association between Methylmercury Exposure from Fish Consumption
and Child Development at Five and a Half Years of Age in the Seychelles
Child Development Study: An Evaluation of Nonlinear Relationships
*Children, mercury, fish, prenatal, postnatal, Axtell, Cox, Myers, Davidson, Choi, Cernichiari, Sloane-Reeves, Shamlaye, Clarkson
Stress and the Blood Brain Barrier
*pyridostigmine, acetylcholinesterase, CNS, Israeli soldiers, Gulf War Syndrome, Catecholamines, stress, rats
Late Adolescent and Young Adult Outcomes of Girls Diagnosed With ADHD in Childhood: An Exploratory Investigation
Inhibiting Noradrenergic Overactivity by Inhibition of Thromboxane and Concomitant Activation of Opiate Receptors via Dietary Means
*Addiction, Serotonin, Melatonin, Calcium, Anxiety, Depression, Schizophrenia, Sleep, Enuresis, TS, Tourette, Parkinson, Alzheimers, Dementia, Anorexia, ADHD, AIDS
The effects of salicylate on the activity of rat liver tryptophan pyrrolase in vitro and in vivo
The effects of salicylate on the activity of tryptophan pyrrolase in rat liver
The Mechanism of Inhibition of Rat Liver Tryptophan Pyrrolase Activity
by 4-Hydroxypyrazolo[3,4-d]pyrimidine (Ailopurinol)
Tryptophan and tryptophan pyrrolase in haem regulation.
* Note: Tryptophan is bound in the liver, controlling its availability for liver functions. Palmitate, salicylate, morphine, and theophylline affect levels of tryptophan. Propranolol and naloxone (opiate-receptor antagonist) prevent these changes.
Mechanisms of Elevation of Rat Brain Tryptophan Concentration by Various Doses of Salicylate
* Smallest dose of salicylate which displaces tryptophan from binding site is 2.5 mg/kg - it causes rise in brain tryptophan.
- Note: Even 0.5 mg/kg raises brain tryptophan, by inhibiting activity of liver tryptophan pyrrolase (enzyme).
Pharmacology and Cell Metabolism: Activation of Liver Tryptophan Pyrrolase Mediates the Decrease in Tryptophan Availability to the Brain after Acute Alcohol Consumption by Normal Subjects
*Alcohol, ethanol, behavior, tryptoophan, dysphoria, aggression
Salicylate Intolerance:
Pathophysiology, Clinical Spectrum, Diagnosis and Treatment
Susto and pesticide poisoning among Florida farmworkers
*Mexican, pesticide, red blood cell cholinesterase, Baer, Penzell
Blind Food Challenge Testing with Wide-Open Eyes
Allergy, Diet, Food
The Biology of Autism
*Autism, genetics, seizures, epilepsy, Down's
Transmission of primary nocturnal enuresis and attention deficit hyperactivity disorder
*ADHD, enuresis, bedwetting, Bailey, Ornitz, Gehricke, Gabikian, Russell, Smalley
Vitamin B12 Excretion as Index of Hepatic Disorder
Vitamins, Total Cholesterol, and
Triglycerides in 642 New York City School Children
Chromosome 2 interstitial deletion (del(2)(q14.1q21)) associated with connective
tissue laxity and an attention deficit disorder
*ADHD, Case study, Developmental delay, microcephaly, forehead, malformed ears, cardiac anomalies, Baker, Rees, Thompson, Howell, Cole, Hughes, Upadhyaya, Ravine
Asthma Management: Part I: An Overview of the Problem and Current Trends
Asthma Management: Part II: Pharmacologic Management
Subjective Mild Depressive Symptoms are Associated With Abnormal Diurnal Cycle of Salivary Cortisol in Older Adults
High-pressure Food Processing
Pharmaceutical excipients and the information on drug labels
Introduction to Allergy Research Foundation Conference Procedings, 1997
Complications of the Ketogenic Diet
*Epilepsy, Seizures, Children, side effects, Gallaban-Gil, Callahan, O'Dell, Pappo, Moshe, Shinnar
Do dietary interventions improve ADHD symptoms in children?
* says "probably not" says outcome measures of studies unvalidated
Common food additives are potent inhibitors of human liver 17a-ethinyloestradiol
and dopamine sulphotransferases
Environmental Risk Factors for Attention Deficit Hyperactivity Disorder
The Effect of Herbal Remedies on the Production of Human Inflammatory and Anti-inflammatory Cytokines
*Sambucol, Protec,
Chizukit, Propolis, Echinacea, Immune System, Barak, Birkenfeld, Halperin, Kalickman
Properties of phenol sulphotransferase from brain of the monkey Rhesus macaca
Behavioral Inhibition, Sustained Attention, and Executive Functions: Constructing a Unifying Theory of ADHD
*Attention, Impulsivity, Hyperactivity, New Model
Coexisting Disorders and Academic Achievement Among Children With ADHD
Difficult asthma
Psychometric Properties of the Food Thought Suppression Inventory in Men - eating disorders, depression, substance abuse, OCD
Symptoms in Children with Convergence Insufficiency: Before and After Treatment
* CI symptoms influences ADHD symptoms, reading, and attention. Diet not mentioned.
The Gold Medal Face of ADHD - Michael Phelps at the Olympics
Diet & Nutrition: Hyperactive Ingredients?
Test of time : Children Who Wait (1973) by Jane Rowe and Lydia Lambert
- children "in care" ... see others: Tarran-Sweeney 2010, DeJong 2010
Letter to the Editor: Atomoxetine Hydrochloride [Strattera] and
Executive Function in Children with Attention-Deficit/Hyperactivity Disorder
* pilot study, 9 children, adhd
* Research funded by Eli Lilly (pharma)
* Barton, Mooney, Prasad. UK & Scotland
Fructose as a key player in the development of fatty liver disease
* obesity, high fructose corn syrup, sugar, diabetes, hyperinsulenemia, insulin resistance, fatty liver.
* Basaranoglu, Sabuncu, Senturk. Turkey. SEE ALSO TETRI 2008
Surveillance of acute flaccid paralysis in Akwa Ibom State, Nigeria 2004-2009
*Vaccines, polio, Africa
Impact of 12-Week Ingestion of Sodium Fluoride on Aggression, Sexual Behavior, and Fertility
in Adult Male Rats
The effects of a double blind, placebo controlled, artificial food colourings and benzoate preservative challenge on hyperactivity in a general population sample of preschool children
Discussion of above study in Science
Rejoinder to Eigenmann PA, Haengelli CA, Food colourings and preservatives—allergy and hyperactivity (Lancet 2004; 364:823–4) and an erratum
Butylated Hydroxytoluene (BHT) induction of pulmonary inflammation: A role in tumor promotion
* BHT, cancer, Bauer, Dwyer-Nield, Keil, Koski, Malkinson
*They found that how many tumors the mice get is related to which kind of mouse and which carcinogen they used with the BHT. In other words, they use the BHT to increase the results of other chemicals that cause cancer. Why? Because they need to study cancer, so they need mice with cancer. So ... why is it still in our breakfast cereal?
Toll-Like Receptor 4 in Butylated Hydroxytoluene (BHT)–Induced Mouse Pulmonary Inflammation and Tumorigenesis
Prenatal and perinatal analgesic exposure and autism: an ecological link
* acetaminophen, circumcision. Bauer, Kriebel.
Alternative and Controversial Treatments for ADHD
*Review, Alternative medicine, Diet, Feingold, Allergy, Sugar, Aspartame, Yeast, Supplements, Vitamins, Magnesium, B6, Zinc, Essential Fatty Acids, Omega 3, EFA, Nootropics, Piracetam, DMAE, Vision, Homeopathy, Auditory, TOmatis, Biofeedback, Hypnotherapy
Salicylic Acid in Soups Prepared from Organically and Non-organically Grown Vegetables
Salicylate, Pesticides, Baxter, Graham, Lawrence, Wiles, Paterson
Identification and determination of salicylic acid and salicyluric acid in urine of people not taking salicylate drugs
* Salicylates, aspirin, see PATERSON 2001, BLACKLOCK 2001
* Baxter, Lawrence, Graham, Wiles, Paterson
Salicylism and herbal medicine
Pediatric fatality secondary to EDTA chelation
Note: The wrong chemical was used, and it was pointed out that the names were similar and often used interchangeably. Nevertheless, the take-home message here, according to the author, was not that medications should be more carefully labeled, or even more carefully used, but that chelation should not be used.
Food intolerance and childhood asthma: What is the link?
* Claims no convincing evidence of food additives, and that food induced asthma is rare.
* Authors Beausoleil, Fiedler, Spergel, claim "no conflicts of interest that are directly relevant"
* Note publication is called Pediatric Drugs
Similarities in features of autism and asthma and a possible link to acetaminophen use
* fever, inflammation, genetic, cytokines, immune system, brain. Becker, Schultz
Ascorbate Restores Endothelium-Dependent Vasodilation
Impaired by Acute Hyperglycemia in Humans
Long-term mercury excretion in urine after removal of amalgam fillings
*Mercury, Dental, Begerow, Zander, Freier, Dunemann
Perfluorochemicals: Potential sources of and migration
from food packaging
FDA, PTFE, nonstick, coatings, food packaging, cookware, pots, Begley, White, Honigfort, Twaroski, Neches, Walker
Abnormal Brain Tryptophan Metabolism and Clinical Correlates
in Tourette Syndrome
*TS, Serotonin, Children, Behen, Chugani, Juhasz, Helder, Ho, Maqbool, Rothermel, Perry, Muzik
Knowledge and attitudes about Attention-Deficit Hyperactivity Disorder (ADHD): A comparison between practicing teachers and undergraduate education students
- Note: See Table 3 on Page 156: In the chart of responses of teachers to "myths" the LOWEST correct score is #16 "Diets are usually not helpful in treating most children with ADHD." The teachers were supposed to agree with this statement, but only 23% of teachers and 22% of students agreed. The authors consider this a problem in that "77% of teachers and 78% of students saw diet as being useful in the treatment of ADHD children." Instead of looking for ways to "re-educate" the teachers on this subject, maybe the authors should have considered the possibility that the teachers are right?
Physiological Responses of Human Adults to Foods Containing Phosphate Additives
Testing the Neural Sensitization and Kindling Hypothesis for Illness from Low Levels of Environmental Chemicals
*MCS, Multiple Chemical Sensitivity, Bell, Rossi, Gilbert,Kobal, Morrow, Newlin, Sorg, Wood
A Comparison of Daily Consumption of Artificial Dye-containing Foods by American Children and Adults
* Children, ADHD, food color, food dye, diet; she counted NUMBER of exposures with no amounts. No indication if toothpaste, mouthwash, shampoo, soap, etc. included. Children had more than twice the number of exposures as adults. This was for her Masters Degree.
Headache and comorbidity in children and adolescents
* migraine, depression, znxiety, epilepsy, sleep, adhd, ts, Tourette, atopic, heart (ischemic stroke, patent foramen ovale, genetic
Functional food science and behaviour and psychological functions
In this review published in 1998, the studies done in 1994 were totally ignored. Bellisle is very negative
on the use of diet -- note that it is on the ILSI website (ILSI is current name of old Nutrition Foundation - they are international powerful food/additive industry organization). In 1998, the only studies they cite are the 1980 Swanson & Kinsbourne study which they criticize and say "maybe" it was not double-blind although it SAYS in the study itself that it was double-blind, and the Weiss 1980 study which they claim was on 22 hyperactive children -- actually these were NOT hyperactive children if you see the study itself which is listed below -- Weiss specifically says that none of them had any clinically significant psychiatric problems, and NONE of them were diagnosed with hyperkinesis (ADHD).
US panel rejects calls for warning labels on link between
food dyes and hyperactivity
Diet and ADHD: Is There A Relationship?
* says it is the belief in the diet that works (placebo), the extra preparation, etc. So he suggests doing all the attention, preparation, shopping, and including children on label reading .. without actually doing the diet. Now THERE's an interesting study idea!!
Eating habits and psychopathology: translation, adaptation, reliability of the
Nutrition Behavior Inventory to Portuguese and relation to psychopathology
* NBI = Nutrition-Behavior Inventory, "is a reliable instrument to correlate eating habits with psychopathology"
* children, adolescents. Benko, de Farias, Cordeiro. Brazil, US.
The Health of Criminals Related to Behaviour, Food, Allergy and Nutrition: A Controlled Study of 100
Persistent Young Offenders
*hyperactivity, adhd, food allergy, diet, nutrition, behavior, Bennett, Brostoff, UK
The Shipley Project: Treating Food Allergy to Prevent Criminal Behaviour in Community Settings
*children, EPD, food allergy, mineral imbalance, behavior, diet, Bennett, McEwen, Rose, UK
Effect of vitamin and mineral supplementation on intelligence of a sample of schoolchildren
Micro-nutrient supplementation and the intelligence of children
* Review of 13 studies. 10 reported positive response in non-verbal measures.
The impact of diet on anti-social, violent and ciminal behavior
*Review, Meta-analysis, elimination diet, omega 3, fatty acids, vitamins, blood sugar, aggression, violence.
The influence of children’s diet on their cognition and behavior
* Says diet works but Egger study using oligoantigenic diet causes him to think Feingold Diet not sufficiently restrictive.schmidt
Mitigation of arsenic-mediated renal oxidative stress in rat by Pleurotus florida lectin
- mushrooms for arsenic poisoning
Study of strawberry flavored milk under pulsed electric field processing
Induction of Depressed Mood Disrupts Emotion Regulation Neurocircuitry and Enhances Pain Unpleasantness
* Sad mood caused greater activity in certain parts of brain, related to pain
* Berna, Leknes, Holmes, Edwards, Goodwin, Tracey
Autism: A unique type of mercury poisoning.
* ARC Research (unpublished?
* Bernard, Enayati, Binstock, Roger, Redwood, McGinnis.
The role of mercury in the pathogenesis of autism
*Autism, thimerosal, vaccines, mercury
Getting Clued In : Inferential Processing and Comprehension Monitoring in Boys With ADHD
Communication and Academic Challenges in Early Adolescence for Children Who Have Been Adopted From the Former Soviet Union
National Toxicology Program's Twelfth Annual Report on Carcinogens
"is reasonably anticipated to be a human carcinogen" ....
The Effect of Pyridoxine Hydrochloride on Blood Serotonin and Pyridoxal Phosphate Contents in Hyperactive Children
- Vitamin B6
The First Report of Fetal Alcohol Effect in a 12 Year-Old Child in Korea
Allergy to Tartrazine in Alprazolam.
Susceptibility to urethane carcinogenesis of transgenic mice carrying a human prototype c-Ha-Ras gene (rasH2 mice) and its modification by butylhydroxytoluene
Butylhydroxytoluene (BHT) increases susceptibility of transgenic rasH2 mice to lung carcinogenesis
The mouse rasH2/BHT model as an in vivo rapid assay for lung carcinogens
In other words, BHT causes other chemicals to produce cancer better and faster. Would you like fries with that?
Nine-week detection of six genotoxic lung carcinogens using the rasH2/BHT mouse model
Magnetic Facilities: Identifying the Convergence Settings of Juvenile Delinquents
Physical activity and mental health in children and adolescents: a review of reviews
*depression, anxiety, self-esteem, physical activity, mental health
Attention Deficit Hyperactivity Disorder - Seminar
Ignores all recent studies, quoting Connors review in 1980 and the Wolraich sugar study. He says: "Although the idea that particular foods or food additives
might cause ADHD received much attention in the
media, systematic studies have shown that this theory is
wrong"
Age-Related Hearing Loss: Is it a Preventable Condition?
*Deafness, aging, antioxidant, diet, salicylate, Bielefeld, Tanaka, Chen, Henderson
Food additives and hyperkinesis - Are
there nuts among the berries?
- rather vicious attack on Dr. Feingold
Association of dietary soy genistein intake with lung function and asthma control: a post-hoc analysis of patients enrolled in a prospective multicentre clinical trial
* eating soy improves asthma. diet, lung. Bime, Wei, Holbrook, Smith, Wise.
Chemicals Introduced in the Processing of Foods
Chemicals Introduced in Foods
Statement on Chemical Additives
Food allergy and asthma.
Salicylic acid in the serum of subjects not taking aspirin. Comparison of salicylic acid
concentrations in the serum of vegetarians, non-vegetarians, and patients taking low dose aspirin
* Salicylates, aspirin. See also PATERSON 2001
* Blacklock, Lawrence, Wiles, Malcolm, Gibson, Kelly, Paterson
Magnesium: Its role in nutrition and carcinogenesis
* Article about magnesium & cancer, but mentions low magnesium impacting ADHD symptoms several times. Blaszczyk & Duda-Chodak. Poland
Phenylketonuria
* PKU, Tetrahydrobiopterin sometimes stimulates phenylalanine hydroxylase (enzyme) activity so they can tolerate more Phe.
Food Additive Excitotoxins and Degenerative Brain Disorders - published openly as an article here
Same article also called Excitotoxins, Neurodegeneration and Neurodevelopment
The Central Role of Excitotoxicity in
Autism Spectrum Disorders
Excitotoxicity: A Possible Central Mechanism in
Fluoride Neurotoxicity
A Possible Central Mechanism in Autism Spectrum Disorders, PART 1
A Possible Central Mechanism in Autism Spectrum Disorders, PART 2: Immunoexcitotoxicity
The Danger of Excessive Vaccination During Brain Development
The Case for a Link to Autism Spectrum Disorders
Mercury Amalgam Fillings: Lies, Damn Lies and Statistics
A Possible Central Mechanism in Autism Spectrum Disorders: Interaction of
Activated Microglia, Excitotoxicity, Reactive Oxygen and Nitrogen Species, Lipid
Peroxidation Products and the Role of Elevated Androgen Levels in Autism
Spectrum Disorders
The Danger of Overvaccination with the Present Vaccine Policy
A Possible Central Mechanism in Autism Spectrum Disorders, PART 3: The role of excitotoxin food additives and the synergistic effecs of other environmental toxins
Immune-Glutamatergic Dysfunction as a Central Mechanism of the
Autism Spectrum Disorders
Cutaneous Aderse Food Reactions in Dogs: Something New to Chew on
*Editorial, skin, food allergy, CAFR=cutaneous adverse food reactions, CAD=canine atopic dermatitis
Attention-deficit-hyperactivity disorder and reward deficiency syndrome
Diet and sleep in children with attention deficit hyperactivity disorder: Preliminary data in Australian children
* ADHD, sleep, diet, sugar, Blunden, Milte, Sinn. Australia
High-fructose corn syrup causes characteristics of obesity in rats: Increased body
weight, body fat and triglyceride levels
The Theory? Diet Causes Violence. The Lab? Prison
Autism and Clostridium tetani
* subacute chronic tetanus infection of GI tract; reduced toxicity. Fragments go to CNS via vagus nerve.
* Medical Hyppotheses. Strategies to test.
ADHD and Reading Disabilities: A Cluster Analytic Approach for Distinguishing Subgroups
- Note: 4 Subgroups were identified. Somebody should do a study to see which of these subgroups reponds best to the Feingold diet.
Excessive Cow's Milk Consumption and Iron Deficiency in Toddlers : Two Unusual Presentations and Review
The impact of attention deficit hyperactivity disorder on recovery from mild traumatic brain injury
* concussion, head injury, brain damage, head trauma, adhd. Bonfield, Lam, Lin, Greene
Diet rich in .-lactalbumin improves memory in unmedicated recovered depressed patients and matched controls
Pg. 322-323. All pages 291-334 available upon request
Pitfalls in Salicylate Toxicity
Foods and Additives are Common Causes of the Attention Deficit Hyperactive Disorder in Children
Pollen Exposure as a Cause for the Deterioration of Neurobehavioral Function of Children with Aautism and Attention Deficit Hyperactive Disorder.
Note: many pollens contain a lot of salicylate. See Shelley 1964
Pollen Exposure as a Cause for the Deterioration of Neurobehavior Function in Children with Autism and Attention Deficit Hyperactive Disorder: Nasal Pollen Challenges
Chronic Fluoride Ingestion Decreases 45Ca Uptake
by Rat Kidney Membranes
Improvement in Academic Behaviors Following Successful Treatment of Convergence Insufficiency
* Eyes, vision. Yes, treatment improves schoolwork. Treatment was various exercise programs; Diet not mentioned
DNA damage and G2/M arrest in Syrian hamster embryo cells during Malachite green exposure are associated with elevated phosphorylation of ERK1 and JNK1
* Dye used as a parasiticide and antibacterial in fish - okay in aquarium, but in farmed fish for food, it remains in the muscle. It is banned in UK. Banned in US since 1983 for food-related use. In 2007, FDA blocked import of fish from China that had this dye.
Decreased Phosphoactive ERKs and JNKs in Malachite-Green-Transformed Syrian Hamster
Embryo Fibroblasts Are Associated with Increased Phosphoactive p38 Kinase: Possible Therapeutic Importance
*Textile dye, used as food dye in India illegally, Bose, Gour, Motiwale, Rao. India
Development and analytical validation of a simple multivariate calibration method using digital scanner images for sunset yellow determination in soft beverages
* artificial dye, Yellow 6. Cheaper, faster way to detect and measure
* Botelho, de Assis, & Sena. Brazil.
Attention-Deficit/Hyperactivity Disorder and Urinary Metabolites of Organophosphate Pesticides.
Prenatal Methylmercury, Postnatal Lead Exposure, and Evidence of Attention Deficit/Hyperactivity Disorder among Inuit Children in Arctic Québec
* Mercury, PCB, Lead. ADHD, behavior. Inuit population, Canada.
* Boucher, Jacobson, Plusquellec, Dewailly, Ayotte, Forget-Dubois, Jacobson, Muckle. Canada.
* stress, depression, startle
Green Colon: An Unusual Appearance at Autopsy
Low-dose naltrexone effects on plasma chemistries and clinical
symptoms in autism: a double-blind, placebo-controlled study
* Naltrexone improved symptoms a little better than placebo for some kids in a one-month trial.
* What was IN placebo, not mentioned. See also BROWN 2009
* Bouvard, Leboyer, Launay, Recasens, Plumet, Waller-Perotte, Tabuteau, Bondoux, Dugas, Lensing, Panksepp. France.
Willingness to pay for adverse drug event regulatory actions
*Pharmaceutical, regulation of drugs, dialysis. Bouvy, Weemers, Schellekens, Koopmanschap, Netherlands, Dutch
Long-chain polyunsaturated fatty acids have a positive effect on the quality of general movements of healthy term infants
Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with ADHD
Low iron stores may contribute to ADHD symptoms
Trends in the Prevalence of Developmental
Disabilities in US Children, 1997–2008
Asthma, allergy and respiratory infections: the vitamin D hypothesis
* Review of data on relationship between vitamin D, asthma, allergy, etc.
* Bozzetto, Carraro, Giordano, Boner, Baraldi. Italy.
The Behavior of Children Receiving Benzedrine - early use of stimulant meds
Biological Contributions to the Presentation and Understanding of Attention-Deficit/Hyperactivity Disorder: A Review
Methylphenidate Transdermal System in Adults With Past Stimulant Misuse: An Open-Label Trial - funded by Shire
Note: no abuse noted in this study, but I recall finding a support group for abusers who wee discussing how to misuse the patch successfully.
Exposures to Environmental Toxicants and Attention Deficit Hyperactivity
Disorder in U.S. Children
* Braun, Kahn, Froehlich, Auinger, Lanphear
* "We conclude that exposure to prenatal tobacco and environmental lead are risk factors
for ADHD in U.S. children."
A “Softer” Approach to Improving the Quality of Refrigerated Bakery Products
- Note - very different from bread you make at home!!
A report on a trial of the low additive, low salicylate diet in the treatment of behaviour and learning problems in children
* ADHD, hyperactivity, additives, food dyes
* Breakey, Hill, Reilly, Connell
Dietary treatment for hyperactive children
Response to NH & MRC: Second Stage of
Consultation re Advice for Health Professionals and Educators re ADHD.
Review: The Role of Diet and Behaviour in Childhood
Letter to the Editor re Diet Therapy, comment on Garland & Weiss 1996 article
A study of the efficacy of the Feingold Diet on hyperkinetic children
(Dr. Brenner originally intended to prove Dr. Feingold wrong. He couldn't, and changed his mind.)
Trace mineral levels in hyperactive children responding to the Feingold diet
- There was a significantly higher level of copper in the children who did respond to the Feingold diet.
A Pediatric Perspective on the Unique Vulnerability and Resilience of the Embryo and the Child to Environmental Toxicants: The Importance of Rigorous Research Concerning Age and Agent
Food Safety: Risk Assessment Methodology
and Decision-Making Criteria
A 70-Kilodalton Recombinant Heat Shock Protein of Candida
albicans Is Highly Immunogenic and Enhances Systemic
Murine Candidiasis.
Dr. Sinaiko's comment, 1998: "More interesting evidence of profound immunologic changes due to Candida. Note: Judge Astle's decision specifically mandates that California doctors will have their licenses revoked for the "incompetence" inherent in believing that Candida affects immune function." Her decision was eventually overturned.
State-of-the-Art: Infant botulism.
* 6 days to 12 months; spores grow in GI lumen and then absorbed.
* Normal bowell flora not yet fully established.
Effectiveness of Varicella Vaccines as Postexposure Prophylaxis.
Theoretical estimation of blood mercury levels from Thimerosal injections using a one compartment biokinetic model.
(An analysis to “bound” potential mercury tissue levels)
Autism-Related Language, Personality, and Cognition in People with Absolute Pitch: Results of a Preliminary Study
* Autism, perfect pitch, see comment by RIMLAND 2003, Brown, Cammuso, Sachs, Winklosky, Mullane, Bernier, Svenson, Arin, Rosen-Sheidley, Folstein
Low-dose naltrexone for disease prevention and quality of life
* Authors promoting this drug to enhance quality of life, stress resistance, social bonding, emotional well-bing
* Also to be used for autism, multiple sclerosis (MS), Crohn's disease, psychiatric problems, autism, depression, etc.
* Is this the new Brave New World's soma? Or Vitamin N?
* Brown & Panksepp.
Vigabatrin, a GABA Transaminase Inhibitor, Reversibly Eliminates Tinnitus in an Animal Model
*Ear, Brozoski, Spires, Bauer
Adverse reactions to food
* Bruijnzeel-Koomen, Orolani, Aas, Bindslev-Jensen, Bjorksten, Moneret-Vautrin, Suthrich. Switzerland.
Pantethine treatment is effective in recovering the disease phenotype induced by ketogenic diet in a pantothenate kinase-associated neurodegeneration
mouse model
* genetic mutation, mitochondria, mouse, ketogenic, nervous system. Italy. Brunetti, Dusi, Giordano, Lamperti, Morbin, Fugnanesi, Marchet, Fagiolari, Sibon, Moggio, d"Amati, Tiranti.brun
Public Deception on Fluoride (book review)
A pilot study to explore the challenges of changing children's food and health concepts
Comparison of Blood and Brain Mercury Levels in Infant Monkeys Exposed to
Methylmercury or Vaccines Containing Thimerosal
* methylmercury via oral gavage, compared to ethylmercury by injection
* Ethylmercury apparently metabolized and excreted faster
* Burbacher, Shen, Liberato, Grant, Cernichiari, Clarkson
Safety Assessment of Castoreum Extract as a Food Ingredient
* Beaver butt glands; no known medical uses but in traditional med it is used as analgesic, and to treat restless sleep & menstrual problems.
* There were two toxicity studies on animals; original data not available; 2 human studies for skin irritation (not food)
Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder
A Single Subject Evaluation of the K-P Diet for Hyperkinesis
Final Amended Report on the Safety Assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate,
Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl Thioglycolate, Isopropyl Thioglycolate, Magnesium Thioglycolate, Methyl
Thioglycolate, Potassium Thioglycolate, Sodium Thioglycolate, and Thioglycolic Acid
- cosmetic chemicals, used in hair coloring, depilatories, etc. (67 pages long)
Fear of Food: A Diary of Mothering
Palette of Our Palates: A Brief History of Food Coloring and Its Regulation
Same as above, before publication
Do maternal protective behaviors alleviate toddlers’ fearful distress?
Knowledge and information about ADHD: Evidence of cultural differences among African-American and white parents
* Black parents less likely to know about ADHD, more likely to think it is caused b too much sugar, and less likely to want to use written information. Criticism of doctors who "still" recommend sugar restriction and special diets.
Use of Complementary and Alternative
Medicine for Symptoms of Attention-Deficit Hyperactivity Disorder
(suggests doctors should find out what they are using and talk them out of it)
What ‘‘Dr. Mom’’ ordered: A community-based exploratory study of parental self-care responses to children’s ADHD symptoms
* diet mentioned as not helpful, using up parental resources & most used for ODD. Questionnaire. Bussing, Koro-Ljungberg, Williamson, Gary, Garvan.
Including Blood Lead Levels of All Immigrant Children When Evaluating for ADHD
A Peptide Found in Schizophrenia and Autism Causes Behavioral Changes in Rats
The National Autistic Society, Vol 3(1) 85–95
Autism and Schizophrenia: Intestinal Disorders
- 81% of autistic children improved.
Evaluating homeopathic drugs within a biomedical framework
Clinical trials bureaucracy: unintended
consequences of well-intentioned policy
Effect of wheat bran and flaxseed on cadmium effects and retention in rats
Attitudes of healthcare professionals and parents regarding genetic testing for violent traits in childhood
Heel Ulcer Incidence Following
Orthopedic Surgery: A Prospective,
Observational Study
Recurrent Abdominal Pain, Anxiety, and Depression in Primary Care
"Helicobacter
pylori infection and celiac disease are not
etiologic in most cases, and despite suspicions about
food allergies, lack of dietary fiber, gluten sensitivity,
and lactose malabsorption, results of dietary
intervention such as fiber supplementation and lactose-
free diets have been disappointing."
AAP Policy Statement: Health Appraisal Guidelines for Day Camps and Resident Camps
Health Canada Proposal to Improve Food Colour Labelling Requirements
highlights of the 2002 issue of the British Journal of Psychiatry ... including the Gesch study on vitamins for violence, sex and antipsychotic meds, etc.
Perinatal and childhood risk factors for later criminality and violence in schizophrenia: Longitudinal, population-based study
Effect of maternal dietary exclusion on breast fed infants with eczema: two controlled studies.
Impulsive Choice Induced in Rats by Lesions of the Nucleus Accumbens Core
Rational dosages of nutrients have a prolonged effect on learning disabilities.
A dietary management of severe childhood migraine.
Effects of a few foods diet in attention deficit disorder
- Needs legal size paper to print. Emphasis in red is added.
Systematized Contact Dermatitis and Montelukast in an Atopic Boy
* aspartame, formaldehyde, allergy. Castanedo-Tardan, Gonzalez, Connelly, Giordano, Jacob.
Anatomic magnetic resonance imaging studies of attention-deficit/hyperactivity disorder
* Neuroimaging, ADHD, children
Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder
* ADHD, children, brain volumes, change in medicated children.
* Castellanos, Lee, Sharp, Jeffries, Greenstein, Clasen, Blumenthal, James, Ebens, Walter, Zijdenbos, Evans, Giedd, Rapoport.
Interactions Between Additives: Its Effect on Sorbate Stability and Z. bailii Minimum Inhibitory Concentration in Model Aqueous Systems Resembling Salad Dressings
Antioxidant Treatment Ameliorates Respiratory Syncytial Virus–induced Disease and Lung Inflammation
* oxidative stress, asthma, RSV, BHA, antioxidants
* Using BHA as a medication - but BHA together with BHT (in foods, in humans) results in lung tumor promotion so maybe a safer antioxidant is a better choice?
Spectrum and Possible Mechanism of Carrageenan Cytotoxicity
* Suppresses delayed hypersensitivity by killing macrophages via lysosome damage.
* Catanzaro, Schwartz, Graham.
Alterations in average spectrum of cochleoneural activity by long-term salicylate treatment in the guinea pig: a plausible index of tinnitus
Auditory sensori-neural alterations induced by salicylate.
The two Cazals studies above show tinnitis (noise in ears) as result of salicylate. This one also says salicylate can produce changes in hearing, difficulty in understanding speech, hypersensitivity to noise, etc. These are some of the problems often improved using the Feingold Program Stage One - which eliminates salicylate-containing foods.
b-Endorphin levels in peripheral blood mononuclear cells and long-term
naltrexone treatment in autistic children
* Autism. Symptoms got a little better during treatment.
* Cazzullo, Musetti, Musetti, Bajo, Sacerdote, Panerai. Ialy.
Lead Poisoning Associated with Imported Candy and
Powdered Food Coloring -- California and Michigan
*Case studies, Mexico, spice, lozeena, Iraq, epidemiology, Dorfman, tamarindo, picarindo, jellied, candy, pottery, chili, spices, India
Increased Fruit and Vegetable Intake May Reduce the Nutrition-Related Health Disparities in African Americans
Tartrazine and prostaglandin system
- Tartrazine (Yellow #5) causes bronchoconstriction similiar to aspirin in aspirin-sensitive asthmatics
Toxicity And Carcinogenicity Studies Of 4-Methylimidazole In F344/N Rats And B6c3f1 Mice
*NIH, toxicology, dyes, rats, mice, mouse, cancer, leukemia, thyroid, hyperactivity, seizures, neurobehavioral, Chan, Hills, Kissling, Nyska, Israel, North Carolina
Allergic Diseases in Preschoolers are Associated with Psychological and Behavioural Problems
* allergic rhinitis, atopic dermatitis, asthma, sleep
The Hyperactive Child
Review: Oxidative stress in atism.
* Glutathione, inflammation, abnormal iron and copper metabolism.
N.3 Fatty acids and cognitive and visual acuity development: methodologic and conceptual considerations
Artificial Food Color Additives and Child Behavior
*criticizes Weiss 2012; refers to old studies; Cheeseman is Acting Director, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition (of FDA)
The Response of Elderly Veterans to Daily Vitamin D3 Supplementation of 2,000 IU: A Pilot Efficacy Study
* 62% of veterans 70+ years old had low Vitamin D. 2,000 IU Vitamin D3 was safe and corrected low Vitamin D3 in most (not all) of them.
* No adverse events; no change in calcium levels.
* Parathyroid hormone suppressed if calcium low, so supplemented those not eating enough calcium.
* Cherniack, FLorez, Hollis, Roos, Troen, Levis.
Malignant Tourette Syndrome
Comparative nephrotoxicity induced by melamine, cyanuric acid, or a mixture of both chemicals in either Sprague-Dawley rats or renal cell lines
* Combination of melamine and cyanuric acid caused kidney damage.
* Choi, Kwak, Kwak, Kim, Han, Roh, Bae, Ahn, Jung, Kwon, Jang, Lim, Kwack, Han, Kang, Kim, Kim, Lee
Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis
* children neurodevelopment, IQ, prenatal exposure.
* Choi, Sun, Zhang, Grandjean. Denmark. China.
Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies
* Higher levels of Vitamin D lowers mortality risk. Interventions with lower dose for short time had increased risk.
Chronic aspartame affects T-maze performance, brain cholinergic receptors and Na+,K+-ATPase in rats.
*Rats, brain, enzymes, maze
Reduction of Azo Dyes by Intestinal Anaerobes
- an oldie but goodie, showing metabolism of dyes by breakage of the azo bond into carcinogenic metabolites.
Mutagenicity testing of some commonly used dyes.
Effects of butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) on the acetylation of 2-aminofluorene and DNA-2-aminofluorene adducts in the rat.
Daily intake assessment of saccharin, stevioside, D-sorbitol and
aspartame from various processed foods in Korea
* Artificial sweeteners aspartame & saccharin were low, with "high users" at 40.7% and 11.4% of ADI. Stevia and D-sorbitol have no ADI. Splenda/sucralose not mentioned.
* Chung, Suh, Yoo, Choi, Cho, Cho, Kim. Korea.
Importance of a balanced diet on the physical fitness level of schoolchildren aged 6–12
The Relationship Between Parental Concerns and Final Diagnosis in Children With Developmental Delay
Health Risks of Selected Performance-Enhancing Drugs
Aspartame-Induced Fibromyalgia, an Unusual but Curable Cause of Chronic Pain.
*Ciappuccini, Ansemant, Maillefert, Tavernier, Ornetti
Comparison of four human studies of perinatal exposure to methylmercury for use in risk assessment.
* Mercury, prenatal, Indian, fishing villages, risk management.
Cadmium Exposure and Neurodevelopmental Outcomes in U.S. Children
* cadmium at levels thought safe -> learning disability, LD, ADHD, special ed.
* Ciesielski, Weuve, Bellinger, Schwartz, Lanphear, Wright.
Rotavirus Isolate W161 Representing a Presumptive New
Human Serotype
* New rotavirus W161 found;
* author has no explanation for high antibody titers to it in human sera & cow's milk.
* This was over 20 years ago; perhaps there is more info now?
* Clark, Hoshino, Bell, Groff, Hess, Bachman, Offit.
An Examination of Dietary Influences on Delinquency
* No statistical correlation found. Author says self-report of delinquency and diet are poor design.
Autistic symptoms in children with attention de®cit-hyperactivity disorder
* DAMP = Disorders of Attention, Motor Control and Perception
* 65-80% of parents reported autistic symptoms in children with ADHD; 63.6% also ODD or CD. Clark, Feehan, Tinline, Vostanis. UK
Safety, efficacy, and immunogenicity of a live, quadrivalent human-bovine reassortant rotavirus vaccine in healthy infants.
* same as placebo; some virus shedding, showing "at least a low level of replication in the human host.
* Clark, Bernstein, Dennehy, Offit, Pichichero, Treanor, Ward, Krah, Shaw, Dallas, Digilio, Eiden, Ivanoff, Kaplan, Heaton.
* Funded by Merck; researchers were current or former Merck employees.
Vaccines for rotavirus gastroenteritis universally needed for infants.
* Pediatricians will explain to parents the necessity for a rotavirus vaccine.
* History of rotashield vaccine and intussusception. Rotashield withdrawn.
* Rotateq being tested internationally on 60,000 infants.
EEG evidence for a new conceptualisation of attention deficit hyperactivity disorder
* EEG, 2 groups
The Maternal Phenylketonuria Project: A Summary of Progress and Challenges for the Future
Cognitive Inflexibility after Prefrontal
Serotonin Depletion Is Behaviorally and Neurochemically Specific
Evidence childhood epidemics of type 1 and type 2 diabetes are opposite extremes of an immune spectrum disorder induced by immune stimulants. Role of race and associated cortisol activity as a major determining factor of the type of diabetes
* vaccines stimulate immune system.grass fed horses immunized and obese. author is Classsen Immunotherapies - patents on testing vaccines for ability to cause diabetes.
Prevention of Cognitive Deficits and Brain Oxidative Stress with
Superoxide Sismutase/Catalase Mimetics in Aged Mice
*Aging, cognitive function, antioxidents, oxidative stress, Clausen, Doctrow, Baudry
A preliminary study of the effect of pyridoxine administration in a subgroup of hyperkinetic children: a double-blind crossover comparison with methylphenidate.
Fathers and Pediatricians: Enhancing Men’s Roles in the Care and Development of Their Children
Parental Attributions for Success in Managing the Behavior of Children With ADHD
Intolerance to Additives
Nutrigenomics of hepatic steatosis in a feline model: effect
of monosodium glutamate, fructose, and Trans-fat feeding
* MSG, cat, genes, liver disease. Collison, Zaidi, Saleh, Makhoul, Inglis, Burrows, Araujo, Al-Mohanna.
Prediabetic changes in gene expression induced by aspartame and monosodium glutamate in
Trans fat-fed C57Bl/6 J mice
* nutrasweet, aspartame, msg. Liver, trans-fat, cholesterol. Mice. Collison, Makhoul, Zaidi, Inglis, Andres, Ubungen, Saleh, Al-Mohanna.
Commentary on: "Further studies are necessary in order to conclude a causal association between the consumption of monosodium L-glutamate (MSG) and the prevalence of the metabolic
syndrome in the rural Thai population" by Insawang.
* MSG, metabolic syndrome, Thailand
Fatty acid status and behavioural symptoms of Attention Deficit
Hyperactivity Disorder in adolescents: A case-control study
Commission on Crime Control and Violence Prevention (See Crime 1981)
Physical Manifestations of Neurodevelopmental Disruption: Are Minor Physical
Anomalies Part of the Syndrome of Schizophrenia?
Dose-Time Effect of Artificial Colors in Hyperactive Children
Note: 30 mg food dye in chocolate cookies used as challenge material
Food additives and hyperkinesis: A controlled double-blind experiment
One of the early double blind diet studies, even before Harley
- See also letter from MILLER 1978
Food Additives and Hyperactive Children (book)
Pattern of intake of food additives associated with hyperactivity in Irish children and teenagersNote - Ireland was already in the process of taking food dyes out of the kids' food.
Attention deficit hyperactivity disorder and whole-blood serotonin levels: effects of comorbidity
* Srotonin levels of children related to levels of their mothers. Children with ADHD + CD or ODD had higher serotonin.
* Other studies show a dietary connection to serotonin function, useful even if there is genetic differences.
See BACKON 1989, BHAGAVAN 1977, DALAL 2010 to start.
* Cook, Stein, Ellison, Unis, Leventhal
Are there critical periods for brain growth in children born preterm?
ADHD Drugs and Serious Cardiovascular Events in Children and Young Adults
Antenatal Acetaminophen Use and Attention-Deficit/Hyperactivity Disorder
* ADHD, Tylenol, 60,000+ people reported Tylenol use during pregnancy
* the more weeks the Tylenol taken, the more ADHD, the more hyper ... but causation not proved yet.
* Cooper, Langley, Thapar. Denmark
Hyperactivity and diet.
* Editorial, history, Canadian Medical Association Journal
Treatment of depression: time to consider folic acid and vitamin B12
Co-Occurrence of ADHD and High IQ: A Case Series Empirical Study
Aspirin, Salicylate, Sulfite and Tartrazine Induced Bronchoconstriction. Safe Doses and Case Definition in Epidemiological Studies.
Diet and Child Behavior Problems: Fact or Fiction?
- pediatric nursing article, tries for a balanced view, sort of. Reviews all the old studies as though they are definitive, but does introduce the newer studies showing that additives do affect behavior, commenting that these studies have a selection bias because of "possible overrepresentation by families interested in hyperactivity." (And here I thought studies on kids with hyperactivity were supposed to study kids WITH it .... ?)
Positive Association between Helicobacter pylori Infection and Food
Allergy in Children
*Allergy, H. pylori, Corrado, Luzzi, Lucarelli, Frediani, Pacchiarotti, Cavaliere, Rea, Cardi, Italy.
Attention-deficit/hyperactivity disorder,
Tourette’s syndrome, and restless legs syndrome:
The iron hypothesis
Sleep Disturbances and Serum Ferritin Levels in Children with ADHD
*adhd, sleep, children, Cortese, Konofal, Bernardina, Mouren, Lecendreux, France
Depression in adult untreated celiac subjects: diagnosis by the pediatrician
Phenol sulphotransferase SULT1A1 polymorphism : molecular diagnosis
and allele frequencies in Caucasian and African populations
*phenol sulphotransferase, PST, sulfation, sulphation
Current Findings and Research Trends in Violence Prevention - Nutrition and Biochemical Influences
Commission on Crime Control and Violence Prevention
Differential Effects of 6-OHDA Lesions of the Frontal Cortex and Caudate Nucleus on the Ability to Acquire an Attentional Set
Hair mineral analysis: Biochemical imbalances and violent criminal behavior
* significantly different levels of trace minerals violent & nonviolent criminals; zinc to copper ratio most important
* "results of this study indicate that biochemical differences exist between violent and nonviolent criminals."
* Cromwell, Abadie, Stephens, Kyler.
Systemic Manifestations Due to Allergy
Reviews cases in the 1950s, before additives much in the diet, and diagnosis of "tension fatique syndrome."
Adolescents Who Intend to Change Multiple Health Behaviours Choose Greater Exposure to an Internet-delivered Intervention
Do Foods or Additives Cause Behavior Disorders?
* ADHD,
* Note: Although this review is dated 2006, it reviews the studies done in the 1970s, meta analysis done in 1982 (ignoring the Schab meta analysis of 2004), the NIH conference in 1982 (but not 1998)... and ignoring most of the new studies or belittling them. The Bateman 2004 study is described, then dropped in favor of a long list of "negative" studies - all of them from the 1970s or 1980s.
The history of bronchial asthma from the ancient times till the Middle Ages
Chemical Cuisine 2008
* Food additives, food dyes, bht, bha, aspartame, etc.
Education in Child Neurology: The Role of the International Child Neurology Association (ICNA)
CSPI (Voodoo Science etc.) SEE HARNIK 1982
Autism Spectrum Disorders in Tuberous Sclerosis: Pathogenetic Pathways and Implications for Treatment
Do stimulant medications improve educational and behavioral outcomes for children with ADHD?
* Increase in use of stimulant drugs is associated with worse academic performance. Reasons discussed.
Do stimulant medications improve educational and behavioral outcomes for children with ADHD?
* Increase in use of stimulant drugs is associated with worse academic performance. Reasons discussed. Currie, Stabile, Jones.
Reward Dependence is Positively Related to Urinary Monoamines in Normal Men
* Avoiding harm, reward dependence, novelty seeking - all depend on MAO system.
* MAO level in urine related to reward dependence.
* Curtin, Walker, Peyrin, Soulier, Badan, Schulz.
Nutritional and Environmental Approaches to Preventing and Treating Autism and Attention Deficit Hyperactivity Disorder (ADHD): A Review
* Toxins, mercury, lead, pesticides, prenatal smoking.
*omega 3, vitamins, zinc, magnesium, phytochemicals, chelation. Curtis & Patel.
Epilepsy and sudden unexpected death in epilepsy? Eat more fish!
Role of IVIg in autoimmune, neuroinflammatory and neurodegenerative disorders of the central nervous system: present and future prospects
* CNS, Alzheimer's, neurodegeneration
IVIg in other autoimmune neurological disorders: current status and future prospects
* autoimmune, Alzheimer's, fibrosis.
Involvement of high plasma corticosterone status and activation of brain regional serotonin metabolism in long-term erythrosine-induced rearing motor hyperactivity in young adult male rats
*food colors, hyperactivity, serotonin, Dalal, Poddar, India
Paraoxonase gene variants are associated with autism
in North America, but not in Italy: possible regional
specificity in gene–environment interactions
* Organophosphate pesticides, PON1
Prophylactic Treatment of Migraine in Children. Part 1. A Systematic Review of non-Pharmacological Trials
Case Report: Vicia faba Hypersensitivity and ASA Intolerance in a Farmer: A Case Report
*Asthma, allergy, legumes, methyl salicylate, beans, Damiami, Aloia, Priore, Pastore, Nardulli, Lippolis, Macchia, Ferrannini
Developmental neurotoxicity assessment in zebrafish: a survey of 200 environmental toxicants
* D'Amico, Li, Seng, McGrath
Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed DAPTACEL
* Package insert
Gluten for Punishment
- article re celiac disease
Fixed-Interval Performance and Self-Control in Children
The Relationship of Hyperactivity to Moderately Elevated Lead Levels
Reactions to dietary tartrazine
Note: While he used a high dose - 250 mg Yellow 5 -- he tested children already in the throws of reactions. He attracted parents of children who were not doing well in their efforts at using dietary intervention, although the parents claimed that they saw some effect. They were requesting his help. Instead, he treated the parents like neurotics to whom he intended to prove that their children were not sensitive to food dyes. He used neither cognitive testing, learning testing, nor parent questionnaire - his method was to ask the busy nurses to "observe" the children.
Maternal diet and offspring development
* obesity, maternal obesity increases risk of adhd ... similar to prenatal alcohol exposure
Attention deficit hyperactivity disorder: A review of the essential facts.
* Because the Southampton studies showed that NON-ADHD children were also vulnerable to adverse reactions to food dyes, Daley claims that means that diet as a therapy for ADHD is "doubtful" ... UK.
The Presence of Comorbidity in Tourette Syndrome Increases the Need for Pharmacological Treatment.
Personality Pathology Comorbidity in Adult Females with Eating Disorders
Dietary Estrogens Stimulate Human Breast Cells to Enter the Cell Cycle.
Some reflections on the use of psychiatric diagnosis in the looked after or “in care” child population
- see also Tarren-Sweeney 2010
Home environmental health risks of people with developmental disabilities living in community-based residential settings: Implications for community-health nurses.
* Fragile populations and environmental health risks
* Indoor pollutants and community-based residential settings
ArticleOdors as triggering and worsening factors for migraine in men
* headache, perfumes, fragrance. Osmophobia. deLima, Sapienza, Giraud, Fragoso. Brazil.
Rating of Olfactory Judgements in Migraine Patients
Controlled trial of cumulative behavioural effects of a common bread preservative
Calcium propionate is one of the additives not eliminated on the Feingold diet, but products containing it are marked. In Australia, where this study was done, the amount used in the bread is much higher than here in the US
Vaccine-associated paralytic poliomyelitis: a retrospective cohort study of acute flaccid paralyses in Brazil.
Depression: See CORVAGLIA 1999, OGLETREE 2001, VERKASALO 2005
Marine omega-3 polyunsaturated fatty acids induce sex-specific changes in reinforcer-controlled behaviour and neurotransmitter metabolism in a spontaneously hypertensive rat model of ADHD
* Omega 3, ADHD, rats
Anxiety, panic and adult asthma: A cognitive-behavioral perspective
* asthma, anxiety, hyperventilation, stress, distress, cognitive-behavioral therapy. Deshmukh, Toelle, Usherwood, O'Grady, Jenkins. Australia
Transcriptional activity of quinone methides derived from the tumor
promoter butylated hydroxytoluene in HepG2 cells
*BHT, tumor promoter, cytochrome P450, Desjardins, Beard, Mapoles, Gee, Thompson
Age at First Measles-Mumps-Rubella Vaccination in Children With Autism and
School-Matched Control Subjects: A Population-Based Study in Metropolitan Atlanta
* Vaccines, MMR, autism. DeStefano, Bhasin, Thompson, Yeargin-Allsopp, Boyle.
Pittsburgh Compound B (11C-PIB) and Fluorodeoxyglucose (18 F-FDG) PET in Patients With Alzheimer Disease, Mild Cognitive Impairment, and Healthy Controls
Tartrazine in Atopic Eczema
Neurological morbidity in vaccine-associated paralytic poliomyelitis in Brazil from 1989 up to 1995.
Role of zinc in maternal and child mental health
ADHD in the College Student: Is Anyone Else Worried?
Urinary metabolites of histamine and leukotrienes before and after placebo-controlled challenge with ASA and food additives in chronic urticaria patients
* allergy, salicylates, tartrazine, yellow 5, sodium benzoate, msg, sulfite
* DiLorenzo, Pacor, Vignola, Profita, Esposito-Pellitteri, Biasi, Corrocher, Caruso. Italy.
* Note: maximum tartrazine tested = 20 mg
Epidemiology of Pediatric Holiday-Related Injuries Presenting to US Emergency Departments
* children
Usage pattern and exposure assessment of food colours in different age groups of consumers in
the State of Uttar Pradesh, India
*food colors, food dyes, ADI, Dixit, Purshottam, Gupta, Khanna, Das, India
Usage pattern of synthetic food colours in different states of India and exposure assessment through
commodities preferentially consumed by children
A Simple Method for Simultaneous Determination of Basic Dyes Encountered in Food Preparations by Reversed-Phase HPLC
*food dyes, Dixit, Khanna, Das, India
Inhaled sodium metabisulphite induced bronchoconstriction:
inhibition by nedocromil sodium and sodium cromoglycate
* sulfite, asthma. Dixon, Ind. UK.
Reactions to aspirin and food additives in patients with chronic urticaria, including the physical urticarias
* 19 of 23 aspirin-sensitive patients (82.6%) also reacted to tartrazine (Yellow 5), sodium benzoate, indomethacin, etc. Netherlands.
ADHD and drug therapy: is it still
a valid treatment?
- Does not mention eliminating additives, but has a wonderful quote at very end:
"Currently, parents, teachers, and doctors make decisions about drug therapy –
being the same ones who appear to receive the greatest benefit from it. In the
future, these decision-makers should consider selecting therapies less on the
needs of adults and more on the long-term needs and benefits of children."
Effects of maternally exposed colouring food additives on cognitive performance in rats
*Rats, coloring, hyperactivity, Learning, Children, food dyes, tartrazine, red 40, yellow 5, red 3, yellow 6, blue 1, blue 2, Gultekin, Doguc, Ceyhan, Ozturk, see Gultekin 2012
Relapsed Schizophrenics: Earlier Discharge from the Hospital After Cereal-Free, Milk-Free Diet
Coeliac Disease and Schizophrenia
FDA clearance paves way for computerized ADHD monitoring
* QB test, quantified behavior test
Nutritional and other natural medical treatments for attention-deficit/hyperactivity disorder.
The Role of Allergy in Recurrent Otitis Media with Effusion
*Ear Infection, Children, Doner, Yariktas, Demirci
The clinical practice of Cognitive Behavioural Therapy for children and young people with a diagnosis of Asperger’s Syndrome
L-DOPA biotransformation: correlations of dosage,
erythrocyte catechol O-methyltransferase and platelet
SULT1A3 activities with metabolic pathways
in Parkinsonian patients
*phenol sulfotransferase, PST
Colouring our foods in the last and next millennium
* Natural and artificial colors, history, market trends
* Downham, Collins. UK.
Body Mass Index of Children With Attention-Deficit/Hyperactivity Disorder
- ADHD kids less obese than normal kids
Mercury from chlor-alkali plants: measured concentrations in food product sugar
- (resulting in mercury in corn syrup)
Mercury exposure, nutritional deficiencies and metabolic disruptions may affect
learning in children First link is 41 pages. Formatted link here prints in 15 pages.
A macroepigenetic approach to identify factors responsible for the autism
epidemic in the United States
* Genes, diet, nutrition, zinc, metals, PON1, mercury, organophosphate pesticides, high fructose corn syrup, HFCS
Exclusive breast-feeding for at least 4 months protects against otitis media.
Natural salicylates: foods, functions and disease prevention
*Salicylates, disease prevention, Duthie, Wood.
Hypotonic-Hyporesponsive Episodes Reported to the Vaccine Adverse Event Reporting System (VAERS) 1996-1998.
Epistatic interactions govern chemically-induced lung tumor
susceptibility and Kras mutation site in murine C57BL/6J-ChrA/J
chromosome substitution strains
Note: "Tumor multiplicity increased if BHT administration followed urethane exposure ..."
Toxicological effects of red wine, orange juice, and other dietary SULT1A
inhibitors via excess catecholamines
* SULT1A = PST enzyme, catecholamine, dopamine, blood pressure, migraine, atrial fibrillitation, diabetes, alcohol
ADHD impacted by sulfotransferase (SULT1A) inhibition from artificial
food colors and plant-based foods
* PST = SULT, adhd, artificial food dyes, colors, tyrosine, dopamine,
* brain, polyphenols, inverted-U ADHD response to inhibition
Discriminative Stimulus Effects of Naltrexone After a Single Dose of Morphine in the Rat
*acute addiction; Easterling, Holtzman; I was the lab tech for this study during my summer internship at Emory U
Autism: Xenobiotic influences
* 16 of 18 autistic children had toxic chemicals in bloos exceeding adult tolerance.
* Abnormal D-glucaric acid & abnormal xenobiotic influence on liver detox.
* Edelson & Cantor. Atlanta, GA
From the Editor: ADHD: Historical Development and Overview - history
Omega-3 polyunsaturated fatty acid levels in the diet and in red
blood cell membranes of depressed patients
* Measured omega-3 in red blood cell membranes - the less omega-3, the worse the depression.
* Edwards, Peet, Shay, Horrobin. UK, Canada.
Some biochemical effects of sub-acute oral administration of L-Arginine on Monosodium Glutamate-fed Wistar Albino Rats. 2: Serum alkaline phosphatase, total acid phosphatase and aspartate aminotransferase activities.
* Arginine (ARG) potentiates the MSG effect on prostate, liver, other organs.
* MSG tested at 5 mg/kg - much lower than 1 g/kg tested by Ali 2012.
* Egbuono, Ezeokonkwo, Ejikeme, Obidoa, Ezeanyika. Nigeria.
Controlled trial of oligoantigenic treatment in the hyperkinetic syndrome
- 62 of 76 selected overactive children (81.6%) improved.
Oligoantigenic diet treatment of children with epilepsy and migraine
- epilepsy & headache: 80% improved. 55% stopped seizures. 25% had fewer seizures.
- this included 75% of those with generalized epilepsy, 100% of those with petit mal, and 85% of those with partial epilepsy.
- Of those with epilepsy ALONE, none improved on diet.
Effect of diet treatment on enuresis on children with migraine or hyperkinetic behavior
- 76% improved.
- missing last page with end of Discussion and References
Hyposensitisation in children with food-induced hyperkinetic syndrome in News for Practitioners, European Journal of Pediatrics (1992) 151: 864-865
- Note: This study involved EPD, in use in England for 30 years but illegal here today.
Controlled Trial of Hyposensitisation in Children with Food-Induced Hyperkinetic Syndrome
Hyperkinetic Syndrome
*adhd, children, food intolerance, behavior, hyperkinetic, aggressive, conduct disorder
Atopic Dermatitis and Asthma: Parallels in the Evolution of Treatment
Comment: Food colourings and preservatives—allergy and hyperactivity
Takes issue with the Bateman study.
"We do not believe that routine testing
should include screening for food colouring and
preservatives as causative factors for hyperactivity. If the
parents raise the question, a diet limited in time — eg, for
3 or 4 weeks — might be instituted, and its effect carefully
assessed by the managing physician. Parents should also be
questioned about the disruption of the diet on the child’s
daily life. If parents and health professionals decide to
continue the diet after the trial period, repeated
assessments — eg, every 6 months—should be done as no
data for the duration of such a diet are available so far. We
strongly believe that unnecessary diets should not be
instituted for hyperactivity."
Cytogenetic effects in children treated with methylphenidate
Letter to the Editor - Comments on ‘Cytogenetic effects in children
treated with methylphenidate’ by El-Zein et al.
Reply to Letter to the Editor by Preston
Treatment of attention-deficit-hyperactivity disorder
* Discussion of drug treatments. Covers all other treatments in one sentence - says not proved effective.
* Elia, Ambrosini, Rapoport.
Color and Psychological Functioning
The Effect of Red on Avoidance Behavior in Achievement Contexts
- the color causes avoidance behavior (color of test booklets, not food color)
Impact of a traffic light nutrition tool in a primary school
Safety of the omega-3 fatty acid, eicosapentaenoic acid (EPA) in psychiatric patients: Results from a randomized, placebo-controlled trial
* Omega-3 used for psychiatric patients, but safety not studied.
* Schizophrenia patients given 2 grams/day or placebo in addition to meds
* 2 grams/day well tolerated; cholesterol lower, bleeding time longer, weight gain
* Emsley, Niehaus, Oosthuizen, Koen, Ascott-Evans, Chiliza, van Rensburg, Smit. S. Africa.
Prenatal Exposure to Organophosphates, Paraoxonase 1, and Cognitive Development in Childhood
*IQ, mental development, pesticides, PON1 geme, neurodevelopment, Engel, Wetmur, CHen, Zhu, Barr, Canfield, Wolff
The Links Between Diet and Behaviour: The influence of nutrition on mental health
- Report of an inquiry held by the Associate Parliamentary Food and Health Forum
Choline transporter gene variation is associatedwith attention deficit hyperactivity disorder
Common Genetic Origins for EEG, Alcoholism and Anxiety: The Role of CRH-BP
*cognitive function, genes, stress, Enoch, SHen, Ducci, Yuan, Liu, White, Albaugh, Hodgkinson, Goldman
* Reclassified as List 4B inert ingredient, for use in pesticides - considered harmless
l-Histidine Decarboxylase and Tourette’s Syndrome.
Pregnant diabetic rats fed the antioxidant butylated hyrdoxytoluene show decrea
*rats, BHT, diabetes, pregnancy, Eriksson, Siman
*As we've said before, maybe it's a good drug - put it on the prescription pad, not on the breakfast table
Sensitization and Subjective Health Complaints
MCS, Fibromyalgia, Pain, Stress, Eriksen, Ursin
Effects of diet on growth and survival of rats fed toxic levels of Tartrazine (FD&C; Yellow No. 5) and Sunset Yellow FCF (FD&C; Yellow No. 6)
* purified diet, fiber
Organophosphate Pesticide Exposure and Neurodevelopment in
Young Mexican-American Children
Increased Sensitivity of Heat-Stressed Saccharomyces cerevisiae Cells to Food-Grade Antioxidants
- TBHQ prevents repair of heat-damaged cells
* See Page 18: "List of the food colours .... additional information" - WARNING to be: "may have an adverse effect on activity and attention in children."
Recognising Coeliac Disease in Eastern Europe – the Hidden
Epidemic in our Midst?
*Celiac Disease, Evans, Hadjivassiliou, Sanders
Effect of diets containing genetically modified potatoes expressing
Galanthus nivalis lectin on rat small intestine
* GMO, lectin genes
5q14.3 Deletion Manifesting as Mitochondrial Disease and Autism: Case Report
Colour and label evaluation of commercial pasteurised red juices and related drinks
The worldwide prevalence of ADHD: Is it an American condition?
Effects of polychlorinated biphenyls on the nervous system
PCB, animals, humans, neurotransmitters, dopamine, behavior, Faroon, Jones, de Rosa
Effects of polychlorinated biphenyls on development and reproduction
*PCB, reproductive effects, humans, animals, development, Faroon, Keith, Jones, de Rosa
Carcinogenic effects of polychlorinated biphenyls
PCB, cancer, Faroon, Keith, Jones, de Rosa
Chronic Conditions, Functional Limitations, and
Special Health Care Needs in 10- to 12-Year-Old Children Born at 23 to 25 Weeks’ Gestation in the 1990s: A Swedish National Prospective Followup Study.
Surprises from Celiac Disease: Study of a potentially fatal food-triggered disease
has uncovered a process that may contribute to many autoimmune disorders
Comorbidity of Asthma With ADHD
Botulinum Toxin A Injections to the Upper Limbs in Children With Cerebral Palsy: Duration of Effect
All References Related to Overview Assessment of
Artificial Food Colors/Additives and Hyperactivity (ADHD) and Problem Behaviors in Children
FDA: Penicillin-containing premixes; opportunity for hearing, re. Diamond Shamrock Chemical Co.
*Application to withdraw penicillin-containing animal feed
All References Related to Overview Assessment of
Artificial Food Colors/Additives and Hyperactivity (ADHD) and Problem Behaviors in Children
Petition by H. B. Perry to delist Yellow 5
Tonsillectomy in the allergic child.
Antigenic property of the oral secretion of fleas
* Benjamini, Feingold
Allergy to flea bites. I. Experimental induction of flea-bite sensitivity in guinea pigs
* Hudson, Feingold, Kartman
Allergy to flea bites. II. Investigations of flea bite sensitivity in humans.
* Hudson, Feingold, Kartman
Allergy to flea bites. III. The experimental induction of flea bite sensitivity in guinea pigs by exposure to flea bites and by antigen prepared from whole flea extracts of Ctenocephalides felis felis
* Benjamini, Feingold, Kartman
Psychological studies of allergic women. The relation between skin reactivity and personality.
Allergy to flea bites. IV. In vitro collection and antigenic properties of the oral secretion of the cat flea, Ctenocephalides felis felis
* Benjamini, Feingold, Young, Kartman, Shimizu
Psychological variables in allergic disorders: A Review. Psychosomatic Medicine, 1964 Sep-Oct;26:543-75.
The role of collagen in the induction of flea bite hypersensitivity.
In vitro studies on the role of collagen in the induction of hypersensitivity to flea bites.
Personality variables and allergic skin reactivity. A cross-validation study. Psychosomatic Medicine, 1967 Jun-Aug;29(4):312-22.
The allergic responses to insect bites
* Feingold, Benjamini, Michaeli
Congressional Record - October 30, 1973
Introduction to clinical allergy, excerpt re fleas, haptens
Why Your Child is Hyperactive, excerpt on flea studies
Hyperkinesis and learning disabilities linked to artificial food flavors and colors.
Hyperkinesis and learning disabilities linked to the ingestion of artificial food flavors and colors.
Speech to Newspaper Food Editors and Writers Association, Milwaukee, WI - "A View From the Other Side")
Speech to American Academy of Pediatrics
Food additives in dentistry.
Dietary Management of Nystagmus
Dietary Management of Juvenile Delinquency
The role of diet in behavior
This was finished a few days before his death. It was published with his obituary (last page)
A Niche for Infectious Disease in Environmental Health: Rethinking
the Toxicological Paradigm
* Environmental health research; Feingold, Vegosen, Davis, Leibler, Peterson, Silbergeld
* (This is Beth Feingold, not related to Ben Feingold)
FERGUSON letter on Swanson & Kinsbourne study - see SWANSON
Chronic malnutrition caused by corn feeding increases the susceptibility for convulsions experimentally induced by onosodium L-Glutamate in rats
* msg, seizures, serotonin, low protein diet makes rats more prone to seizures when injected with MSG
* Feria-Velasco, Orozco-Suarez, Carabez-Torres, del Angel, Beas-Zarate
* Abstract in English; text in Spanish
Salicylate intolerance: a masquerader of multiple adverse drug reactions
*Urticaria, Fernando, Clarke
Can nutrient supplements modify brain function?
Periorbital dermatitis: Causes, differential diagnoses and therapy
* allergy, eczema. Feser, Mahler, Germany.
(Kleinman study) Optimal duration of exclusive breastfeeding: what is the evidence to
support current recommendations?
- Not-so-subtle implication that breastfeeding more than six months may cause nutrient deficiencies.
Saccharin and aspartame, compared with sucrose, induce greater weight gain in adult Wistar rats, at similar total caloric intake levels
* Fiejo, Ballard, Foletto, Batista, Neves, Ribeiro, Bertoluci. Brazil.
High-Dose Pyridoxine and Magnesium Administration in Children with Autistic Disorder: An Absence of Salutary Effects in a Double-Blind, Placebo-Controlled Study
*autism, vitamins B6+Mg found not effective at doses given, Findling, Maxwell, Scotese-Wojtila, Huang, Yamashita, Wiznitzer
* See RIMLAND 1998 response
Changes in Emotions Related to Medication Used to Treat ADHD. Part II: Clinical Approaches - See Part I (Manos 2010)
Is Visceral Fat Reduction Necessary to Favour Metabolic Changes in the Liver?
*obesity, eating disorder, Finelli, Tarantino
Does Environmental Exposure to Manganese Pose a Health Risk to
Healthy Adults?
* neurologic, Parkinson's, environment, toxicity, violence, industrial pollution. © ILSI (food industry organization)
fishbein
Nutritional biochemistry and behavioral disabilities.
* neurotransmitters and dietary precursors, IQ, cadmium, learning disabilities
* Fishbein, Meduski
Letter to Editor re Kupp article about BHA and dental caries
Salicylate sensitivity in children reported to respond to salicylate exclusion
Cognitive and Behavioral OUtcomes After Early Exposure to Anesthesia and Surgery
Toxicity of lead: A review with recent updates
* antioxidants, lead toxicity, chelation, nanoencapsulation, herbal extracts. Flora, Gupta, Tiwari. India
Editorial: Neurotoxicity of Fluoride
Table of Contents of Quarterly Journal of the International Society for Fluoride Research
Brilliant Blue FCF as a Dye Tracer for Solute Transport Studies - A Toxicological Overview
*Blue 1, water flow, solute transport, Flury, Fluhler
Brochure from International Food Additives Council 2007
Status of safety assessments of food additives presently permitted in the EU.
- Objectives Page
Food, Brain and Behavior Conference 1996
See Egger 1997, Millstone 1997, Baldwin 1997
=================================
Stepping through Science’s Door: C. W. Scheele, from Pharmacist’s Apprentice to Man of Science
* 18th century chemist in Sweden. "the perfect scientific hero: humble beginnings,
miraculous discovery, worldwide fame, and an early death caused by long
hours spent working over poisonous substances in a drafty chemical laboratory"
The Fluoride Connection
Patent application: Technique for diagnosing attention deficit hyperactivity disorder
Abstract
Trigger factors mainly from the environmental
type are reported by adolescents with migraine
* stress, sleep, adolescent, children, perfume, fragrance, hot weather, diet. Fraga, Pinho, Andreoni, Vitalle, Fisberg, Peres, Vilanova, Masruha. Brazil.
Asthma induced by sulphur dioxide, benzoate and tartrazine contained in orange drinks
* Asthma. 57% reacted to 25 mg sulfur dioxide, 29% reacted to up to 300 mg sodium benzoate, and 7% reacted to 60 mg yellow 5.
* Author used drinks, not capsules, so absorption by oral mucosa possible.
Prenatal Monosodium Glutamate Causes Long-Lasting
Cholinergic and Adrenergic Changes in
Various Brain Regions
Pyridostigmine Brain Penetration Under Stress Enhances Neuronal Excitability and Induces Early Immediate Transcriptional Response
*Gulf War, blood brain barrier, autoimmune, chemical warfare, central nervous system, mouse, mice, CNS, Friedman, Kaufer, Shemer, Hendler, Soreq, Tur-Kaspa
Stress May Disturb the Blood-Brain Barrier
*discussing Soreq & Friedman's study, brain, Israeli soldiers, Gulf War
Prevalence, Recognition, and Treatment of Attention-Deficit/Hyperactivity Disorder in a National Sample of US Children
* US prevalence of ADHD, by socioeconomic group. children.
* Froehlich, Lanphear, Epstein, Barbaresi, Katusic, Kahn.
Comorbidity of ADHD and Substance Use Disorder (SUD): A Neuroimaging Perspective
Adverse reactions to food additives in children with atopic symptoms
* allergy, food dyes, preservatives
* Fuglsang, Madsen, Halken, Jorgensen, Ostergaard, Osterballe. Denmark
* Note: The "high" doses of food dye given were very low, e.g. 18 mg Yellow 5 - see Table 1, pg. 32
* Note: The followup double blind challenge by pills means that the additives were NOT absorbed through mouth or esophagus or tongue surface. Not surprising that the reactions were even fewer. Nevertheless, reactions WERE reported.
Attention Deficit Hyperactivity Disorder: Coping or Curing?
* commentary article. Fung, Lee. Singapore.
Attention-Deficit Hyperactivity Disorder (ADHD): Does New Research Support Old Concepts?
“Sub-laboratory” Hypothyroidism and the Empirical use of Armour Thyroid
* Review of research supporting existence of sub-laboratory hypothyroidism not detected by usual lab tests, and clinical approach
Adverse Effects of Dietary Fructose
-- (corn syrup)
Natural Approaches to Epilepsy
Consumers with Allergic Reaction to Food: Perception of and Response to Food Risk in General and Genetically Modified Food in Particular
Limited Support for the Efficacy of Nonpharmacological Treatments for the Core Symptoms of ADHD
editorial, American Journal of Psychiatry.
ADHD: What every parent needs to know
Early childhood malnutrition predicts depressive symptoms at ages 11–17
*depression, kwashiorkor, malnutrition, children, Galler, Bryce, Waber, Hock, Exner, Eaglesfield, Fitzmaurice, Harrison, Barbados, Harvard
Early malnutrition predicts parent reports of externalizing behaviors at ages 9–17
*malnutrition, children, behavior, executive functioning, aggression, cognitive impairment, Galler, Bryce, Waber, Medford, Eaglesfield, Fitzmaurice, Barbados, Harvard
Sucrose and delinquency: Oral sucrose tolerance test and nutritional assessment.
*Juvenile delinquent, sugar, nutrition, insulin.
* "Nutritional status of incarcerated delinquents did not differ from that of nonincarcerated subjects on most measures."
* Gans, Harper, Bachorowski, Newman, Shrago, Taylor.
Effect of Food Azo Dye Tartrazine on Learning and Memory Functions
in Mice and Rats, and the Possible Mechanisms Involved
Estudio piloto sin grupo control del
tratamiento con magnesio y vitamina B6
del síndrome de Gilles de la Tourette en niños
An open study evaluating the efficacy and
security of magnesium and vitamin B6 as a
treatment of Tourette syndrome in children (in Spanish)
Study Protocol: New therapeutic approach to Tourette Syndrome in children based on a randomized placebo-controlled double-blind phase IV study of the effectiveness and safety of magnesium and vitamin B6
* vitamin B, magnesium, TS, children, expected to improve symptoms and reduces side effects of meds.
* This is a protocol for a future study; we wrote to them Jan 2013 to ask if study has been done.
* Garcia-Lopez, Perea-Milla, Garcia, Rivas-Ruiz, Romero-Gonzalez, Moreno, Faus, del Castillo Aguas, Diaz. Spain.
Index of Phenyl Food Compounds Found in Common Foodstuffs
* charts, Brigham Young University, UT
Mercury Induces an Unopposed Inflammatory Response in Human Peripheral Blood Mononuclear Cells in Vitro
* Mercury - even a little affects immunity, possibly causing infectious disease or autoimmune disease.
* Gardner, Nyland, Evans, Wang, Doyle, Crainiceanu, Silbergeld.
The Potential of Nutritional Therapy - short article in Science, edited by Jennifer Sills
Attention Problems Mediate the Association Between Severity of Physical Abuse and Aggressive Behavior in a Sample of Maltreated Early Adolescents
The Impact of Psychiatric Comorbidities
on Readmissions for Diabetes in Youth
Defence against bacterial drug resistance
*Antibiotics, drug resistance
Birth Defects, Season of Conception, and Sex of Children Born to Pesticide
Applicators Living in the Red River Valley of Minnesota, USA
Effects of High Fluoride and Low Iodine on Brain Histopathology in Offspring Rats
A two-phased population epidemiological study of the safety of thimerosal-containing vaccines: a follow-up analysis
* ethylmercury. VAERS, DTaP, levels exceeded Federal Safety Guidelines and EPA permissible hair mercury limit total 237.5 ug mercury or 275 if flu shots too
Thimerosal exposure & increasing trends of premature puberty in
the vaccine safety datalink
The biological basis of autism spectrum disorders: understanding causation and treatment by clinical geneticists
The temporal relationship between RotaTeq
immunization and intussusception adverse events in
the Vaccine Adverse Event Reporting System (VAERS)
*Geier, King, Sykes
3 reviews of: PC, M.D.: How Political Correctness Is Corrupting Medicine, a book by Sally Satel, M.D.; New York, Basic Books, 2000, 304 pages, $27
Using Diet to Treat Developmental Coordination Disorder
Lactate-Induced Rage and Panic in a Select Group of
Subjects Who Perpetrate Acts of Domestic Violence
Nutritional Interventions and Therapies in Autism: A Spectrum of What We Know Part 2
Vaccines and Autism: A Tale of Shifting Hypotheses
* Offit explains why MMR, thimerosal, and multiple shots don't cause aautism and where the ideas came from.
* Gerber & Offit.
Influence of supplementary vitamins, minerals
and essential fatty acids on the antisocial behaviour
of young adult prisoners
Dietary supplementation with vitamins, minerals and fatty acids reduced antisocial behavior in young adult prisoners. - Article in Evidence-Based Medicine 2003
Vitamin and fatty acid supplements may reduce
antisocial behaviour in incarcerated young adults - another article on Gesch from Evidence-Based Mental Health
The potential of nutrition to promote physical and behavioural well-being
* food, changing diet, health, obesity, diabetes, cancer, heart disease, mental health, depression, schezophrenia, children, developmental disorders, sugar, behavior, mood, antisocial, crime, physiological markers
New Opportunities in the Treatment of Cognitive Impairments Associated With Schizophrenia
Comorbidity of Psychiatric Disorders and Parental Psychiatric Disorders in a Sample of Iranian Children With ADHD
Association of nail biting and psychiatric disorders in children and
their parents in a psychiatrically referred sample of children
Tactile sensory dysfunction in children with ADHD
Distribution of Symptoms of Attention Deficit-Hyperactivity
Disorder in Schoolchildren of Shiraz, South of Iran
Note: Iran does not allow use of artificial food dyes, yet they found 10% of children with ADHD. We claim 10% here too - indeed, we have been claiming 10% for many years in spite of acknowledging that the rate keeps rising ... if it has been rising dramatically for the past 20 years, how is it still 10%? And when actually investigated in VA the rates were 17% and even higher. Maybe Iran is more honest in this regard?
Sleep Disturbances in Singaporean Children with Attention Defi cit
Hyperactivity Disorder
Can Behavioral Sensory Processing Problems Guide Us to a Better Pharmacological Management of
Children with Attention Deficit Hyperactivity Disorder? A Case Report
Comorbidity of Enuresis in Children With Attention-Deficit/Hyperactivity Disorder
The Predictors of Parent Reported Behaviors Related to Olfactory Information Processing in Children with ADHD
Is It Time to Revise the Definition of Attention Deficit Hyperactivity Disorder?
How do ADHD children perceive their cognitive, affective, and behavioral aspects of anger expression in school setting?
Are GPs adequately equipped with the knowledge for educating and counseling of families with ADHD children?
Acetaminophen may mediate oxidative stress and neurotoxicity
in autism
* Letter to the editor, Medical Hypotheses.
* Tylenol after MMR. sulfation process impairment. oxidative stress.antiapoptotic signaling pathway is impaired.
The effect of dietary education on ADHD, a randomized controlled clinical trial
* When change in diet was considered a continuous variable, diet improvement led to better attention.
* Favorite foods: favorite of the researchers (i.e., good diet, fruit, protein, milk, "does not eat what s/he wants");
* un-favorite foods: fried, fatty, salty, sauced, sweet, candies, pickles, chips, processed fruit juices.
* I bet the kids would not agree to this definition.
Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminium hydroxide in muscle
- (vaccine damage)
Psychopharmacological and Other Treatments in Preschool Children with Attention-Deficit/Hyperactivity Disorder: Current Evidence and Practice
Restricted elimination diet for ADHD: the INCA study
* Discusses methods of implementing a Fengold-type diet for children. Suggests limit of 5 weeks trial. Worries about deficiencies.
In Vitro Inhibition of Phenolsulphotransferase (PST) by Food and Drink Constituents
*Food dyes, PST inhibition, Gibb, Glover, Sandler.
An Australian Exclusion Diet
Management of chronic idiopathic urticaria by the identification and exclusion of dietary factors.
See also SWAIN
Multiple Chemical Sensitivity, Illness, and Culture: On the Margins of Health Care
*Fibromyalgia, CFIDS, MCS
Quantitative Magnetic Resonance Imaging
of Human Brain Development: Ages 4-18
A small dose of toxicology, 2nd edition - free ebook: 280 pages - Author's page
Rare De Novo Variants Associated with Autism Implicate a Large Functional Network of Genes
Involved in Formation and Function of Synapses
Critical review: nicotine for the fetus, the infant and the adolescent?
Attention deficit hyperactivity disorder: A literature review of causes, diagnosis, and treatments.
* Senior research project: A chiropractic viewpoint
Pharmaceutical excipients - where do we begin?
Childhood insomnia: why Chris can’t sleep
*ADHD, depression, behavior
A 12-Month Prospective, Observational Study of Treatment Regimen and Quality of Life Associated With ADHD in Central and Eastern
Europe and Eastern Asia
Independent Analysis of the "Opinion of the European Commission, Scientific Committee on Food: Update on the Safety of Aspartame / E951" (SCF 2002)
* Conflicts of interest, formaldehyde, etc. 64 pages
Methamphetamine Exposure, Iron Deficiency, and Implications for Cognitive-Communicative Function:
A Case Study
The etiology of pellagra.
* Suggestion it is not contagious and might be the diet since the nurses never get it from the patients.
The Prevention of Pellagra: A test of diet among institutional inmates.
* Suggested diet because nurses didn't catch it from patients. Interesting history. See SYDENSTRICKER 1958
A study of the relation of diet to Pellagra incidence in seven textile-mill communities of South Carolina in 1916.
* 66 pages. Reports results at orphanages, prisons, history of various efforts to find cause.
* Goldberger, Wheeler, Sydenstricker. U.S. Public Health Service.
A further study of butter, fresh beef, and yeast as Pellagra preventives, with consideration of the relation of Factor P-P of Pellagra (and black tongue of dogs) to Vitamin B.
* Pellagra cn be prevented/cured by diet; buttermilk works better than powdered milk. Butter doesn't work at all.
* Beef and yeast work.
The beef experiment was done by boiling chopped beef 200 g/day (ugh).
* Goldberger, Wheeler, Lillie, Rogers, US Health Service
Diagnosis and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents
Note: Although this paper complains that "pharmacotherapy alone ... has not yet been shown to improve the long-term outcome for any domain of functioning..." the only comment about diet in this paper is: "...some 20 studies have refuted the efficacy of dietary manipulations (eg, the Feingold diet) in ADHD.62" The footnote brings one to the NIH Consensus Development Conference of 1982 - which had concluded that none of the studies were adequate, and had NOT concluded that anything was refuted. Goldman totally ignored the excellent 1994 studies (Rowe & Rowe, Boris & Mandel).
Technical report: Mercury in the environment: Implications for pediatricians
*mercury, children, Goldman, SHannon, Committee on Environmental Health
The Case against Universal Varicella Vaccination
* chicken pox, shingles, vaccine
Is ADHD a Growth Industry?
Current Literature in ADHD : Summarized by Sam Goldstein
Current Literature in ADHD
Golimstok 2011 -- see Rojas 2011
++++++++++++++++
Citotoxicity of food dyes Sunset Yellow (E-110), Bordeaux Red (E-123), and Tatrazine Yellow (E-102) on Allium cepa L. root meristematic cells
* all 3 dyes were cytotoxic to cells. Yellow 6, yellow 5, Red.
The combined effects of exercise and foods in preventing neurological and cognitive disorders
*exercise, diets, nervous system, cognitive, brain, omega-3,
Did acetaminophen provoke the autism epidemic?
* Tylenol given after vaccination. Aspirin does not cause Reye's. Toxicity of acetaminophen.
Sleep Study Abnormalities in Children With Attention Deficit Hyperactivity Disorder
The Use of Canines in the Detection of Human Cancers
*dogs, urine, Gordon, Schatz, Myers, Kosty, Gonczy, Kroener, Tran, Kurtzhals, Heath, Koziol, Arthur, Gabriel, Hemping, Nesbitt, Tucker-Clark, Zaayer
Broccoli or Broken Windows? The relationship between anti social behaviour and a nutrient deficient diet
* Nutrition, malnutrition, aggression, behavior, anti-social.
Autistic-like findings associated with
a urea cycle disorder in a 4-year-old girl
Ferritin Levels and Their Association With Regional Brain
Volumes in Tourette's Syndrome
Childhood Lead Poisoning: Conservative Estimates of the Social and Economic Benefits of Lead Hazard Control
Effects of artificial colors on hyperactive children: a double blind challenge study
- The challenge dose of food dye not specified, but implied to be 13 mg. Effects more pronounced in younger children (13 mg is a bigger dose for younger children). "...suggesting that artificial food dyes do indeed impair and disrupt the behavior of the children."
Brain-Delivery of Zinc-Ions as Potential Treatment for
Neurological Diseases: Mini Review
*Parkinson's, Alzheimer's, schizophrenia, ADHD, depression, amyotrophic lateral sclerosis, Down's
syndrome, multiple sclerosis, epilepsy, Wilson’s disease and Pick’s disease. Nutrition,Grabrucker, Rowan, Garner.
Urban Educators’ Perceptions of Interventions for Students With Attention Deficit Hyperactivity Disorder: A Preliminary Investigation
*ADHD, Teachers, "Diet not effective", Graczyk, Atkins, Jackson, Letendre, Kim-Cohen, Baumann, McCoy
Kids are different: developmental variability in toxicology
* Graeter, Mortensen, baby, genetic, child, lead, toxicology.
Developmental neurotoxicity of industrial chemicals
Neurobehavioural eff ects of developmental toxicity
* autism, adhd, dyslexia, brain, chemicals
* proposing international clearinghouse to test new and existing chemicals. Grandjean & Landrigan. Denmark.
Blue Colon at Autopsy
Stress Does Not Enable Pyridostigmine to Inhibit Brain Cholinesterase after Parenteral Administration
*Gulf War, chemical warfare, blood brain barrier, mice, stress, Grauer, Alkalai, Kapon, Cohen, Raveh
Effects of non-steroidal anti-inflammatory drugs on cyclo-oxygenase and lipoxygenase activity in whole blood from aspirin-sensitive asthmatics vs healthy donors.
Salicylate elimination diets in children: is food restriction supported by the evidence?
* Failsafe diet. Australia. adhd, eczema, gi ... but no evidence in Medline. 50% have adverse effects, e.g., eating disorders, deficiencies
Salicylate elimination diets in children: is food restriction supported by the evidence?
Salicylate elimination diets in children: is food restriction supported by the evidence?
* quotes other studies; Heller, Heller & Heller
Salicylate elimination diets in children: is food restriction supported by the evidence?
Salicylate elimination diets in children: is food restriction supported by the evidence?
Asthma due to inhaled chemical agents - amprolium hydrochloride - old study
* Asthma, amprolium hydrochloride is chemical in a poultry-food additive.
* Greene, Freedman, UK.
Dietary intake of antioxidant (pro)-vitamins, respiratory symptoms and pulmonary function: the MORGEN study.
Parallel processing
*autism, asperger's
Effect of Sucrose on Hyperkinetic Children
The effect of diets rich in and free from additives on the behavior of children with hyperkinetic and learning disorders.
Guest editorial on Chapel 1982 article: The Feingold Diet
for the Hyperactive Child
Epilepsy in children
HLA–DRB1*01 and macrophagic myofasciitis
- (vaccine damage)
Salicylate Induces Tinnitus through Activation of Cochlear
NMDA Receptors
Allergic and Immunologic Reactions to Food Additives
*Asthma, urticaria, BHA, BHT, Carmine, food dyes, Gultekin, Doguc, see Doguc 2012
The Effect of Low-Level Prenatal Methylmercury Exposure on Visual Recognition Memory in Infant Crab-eating Macaques
* Visual recognition in Macaque monkey babies & human babiesv similar.
* Prenatal exposure to mercury: eyesight still same, but deficit in looking at new things.
* Gunderson, Grant, Burbacher, Fagan, Mottet
Pentoxifylline: Brief Review and rationale for its possible use in the treatment of autism
*autism, drugs, common side effects: insomnia, red eyes, nervousness, up to 33% have GI distress (nausea, vomiting, etc); up to 17% have nervous system effects including hallucinations
Are Incidental Findings on Brain Magnetic Resonance Images in Children Merely Incidental?
Fluoride Effects on Cholesterol Influx and Expression
of the Scavenger Receptor CD36 in THP1 Differentiated
Monocyte/Macrophage Cells
Breath of Life: Stories of Asthma From an Exhibition at the
National Library of Medicine
* SCROLL DOWN after clicking on link.
* History of treatment.
Vitamin B12 status in patients of Turkish and Dutch descent with depression: a comparative cross-sectional study.
Allergic and immunologic reactions to food additives.
* Mentions "hyperkinesis" once; writes about tartrazine without any mention of Rowe studies
Gluten Sensitivity: From Gut to Brain
*Celiac, Coeliac, Hadjivassiliou, Sanders, Grünewald, Woodroofe, Boscolo, Aeschlimann. UK.
Association between social isolation and inflammatory markers in depressed
and non-depressed individuals: Results from the MONICA/KORA study
An association between recurrent otitis media in infancy and later hyperactivity.
Probable adverse reaction to a pharmaceutical excipient
* adverse reaction of newborn baby to benzyl alcohol; gasping syndrome
* "prescribers should be aware of the potential for excipients to cause adverse reactions in addition to the drug itself."
* Hall, Milligan, Berrington
Intake of artificially sweetened soft drinks and risk of preterm delivery: A prospective cohort study in 59,334 Danish pregnant women1
* pregnancy, aspartame, acesulfame-K, prematurity, preterm delivery.
* Halldorsson, Strom, Petersen, Olsen. Denmark.
Clinical trial: B vitamins improve health in patients with coeliac
disease living on a gluten-free diet
* celiac disease, vitamin deficiency, Extra B vitamins -> improvement in anxiety & mood.
* Hallert, Svensson, Tholstrup, Hultberg. Sweden.
Metabolic Effects of Dietary Fructose
- (corn syrup)
Chemicals regulation and precaution: does REACH really incorporate the precautionary principle
* REACH is Registration, Evaluation, and Authorization of CHemicals.
* This paper outlines limitations in REACH in Europe; says it does not support
development of safer alternatives, and discusses possible improvement.
* Hansen, Carlsen, Tickner. Denmark & US.
Beware of Food Additives ...always read labels before buying
Outcome-based comparison of Ritalin versus food-supplement treated children with AD/HD
Hyperkinesis and Food Additives: Testing the Feingold Hypothesis
Synthetic Food Colors and Hyperactivity in Children: A Double-Blind Challenge Experiment
Improving Nutrition Education Newsletters for the Food Stamp Eligible Audience
- i.e., how to write newsletters for dummies
Voodoo Science, Twisted Consumerism
In our genes
Parental Beliefs About Autism: Implications for the treating physician
An article exhorting doctors to screen children at 18 months for autism, and to refer children in a timely fashion to specialists to rule out or confirm a suspected diagnosis. The advice is given in response to a survey in which most parents expressed little or no confidence in their doctor. While this advice to doctors may benefit children by making behavioral interventions available at an earlier age, the advice was unfortunately given with the specified intention of preventing parents from turning to alternative or dietary treatments.
Inhibition of phenolsulphotransferase by salicylic acid: a possible mechanism by which aspirin may reduce carcinogenesis.
(Waring group)
Personal note from Robert Sinaiko, MD 1998: "I suspect this is competitive inhibition, since, unlike salicyllic acid, the known irreversible PST inhibiors are fairly complex polycyclic compounds. This tends to favor my MHPG test for PST actvity, since if salicylic acid influences PST activity, so will acetaminophen."
Immunological studies on Amaranth, Sunset Yellow and Curcumin as food
colouring agents in albino rats.
Toxicological Impact of Amaranth, Sunset Yellow and Curcumin as Food Coloring Agents in Albino Rats
*Food coloring, food dyes, rats, amaranth/Red 2, sunset yellow/Yellow 6, curcumin. No effect on liver and kidney glutathione or lipid peroxide levels. Red 2 caused skeletal abnormality in rat pups. Hashem, Atta, Arbid, Nada, Mouneir, Asaad, Egypt.
- Note: The author says 31.5 mg/kg is the ADI. No - 3.75 mg/kg is the US ADI, and 2.5 mg/kg is the Japan ADI. Red 2 doesn't have an ADI since it is banned.
Effects of Some Synthetic Coloring Additives on DNA Damage and Chromosomal Aberrations of Rats
*Food colors, food dyes, rats, tartrazine/yellow 5, chocolate brown, DNA liver damage, kidney damage, comet assay, Egypt.
Clinical Aspects of Pandemic 2009 Influenza A (H1N1) Virus Infection.
A user guide to the GF/CF diet for autism, asperger syndrome and ADHD
Association of monosodium glutamate intake with overweight in
Chinese adults: the INTERMAP Study
* MSG. He, Zhao, Daviglus, Dyer, Van Horn, Garside, Zhu, Guo, Wu, Zhou, Stamler.
Consumption of monosodium glutamate in relation to incidence of
overweight in Chinese adults: China Health and Nutrition Survey (CHNS)
* MSG. He, Dr, Xun, Sharma, Wang, Zhai, Popkin.
Development of a Pentavalent Rotavirus Vaccine against Prevalent Serotypes of Rotavirus Gastroenteritis
* human bovine reassortant rotavirus vaccine, well tolerated 68.8-76.6% efficacy against rotavirus
* Almost 60% of infants got diarrhea from vaccine; 57.5% got diarrhea from placebo -
* but it is supposed to PREVENT diarrhea, no? Placebo = same chemicals without the virus.
* conflicts of interest: 3 authors work for Merck & 2 hold vaccine patent.
* Heaton, Goveia, Miller, Offit, Clark
Pellagra: Dermatitis, dementia, and diarrhea
* Pellagra is deficiency of niacin. Without skin lesions, it is hard to diagnose.
* Hegyi, Schwartz, Hegyi.
Effect of Some Food Colorants (Synthetic and
Natural products) of Young Albino Rats:
I- Liver and Kidney Functions
*Rats, food color, food dyes, annatto, carmine, fast green/green 3, tumeric, chlorophyll, sunset yellow/yellow 6, quote: "...after administration of colorants, rats became more active, nervous and aggressive." Helal, Zaahkouk, Mekkawy, Egypt.
Progressive effects of the interaction of Sodium nitrite and sunset
yellow on different physiological parameters in albino rats
*Rats, food color, food dyes, sodium nitrite, sunset yellow, yellow 6, selenium, recovery. Egypt.
Effect of Food Preservative and Food Coloring Agent on Some Physiological and Hematological Parameters in Albino Rats and the Protective Role of Garlic
*Rats, Food dyes, coloring, preservatives, sodium nitrite, RBC, WBC, Helal, Abdel-Rahman, Egypt.
ADHD and Bipolar Disorder: Common Causes Common Cure?
Using Prevention Science to Promote Children’s Mental Health: The Founding of the Missouri Prevention Center
Thimerosal Exposure in Infants and Developmental Disorders: A Prospective Cohort Study in the United Kingdom Does Not Support a Causal Association
*Autism, vaccines, thimerosal, mercury, Heron, Golding, ALSPAC team
Beginning:
"There is an established link
between exposure to mercury and impaired childhood cognitive
development and early motor skills."
Conclusion:
"We could find no convincing evidence
that early exposure to thimerosal had any deleterious
effect on neurologic or psychological outcome."
The Feingold Solution: Assessing the Role of Diet in
Children's Behavior
Identifying, Evaluating, Diagnosing, and Treating ADHD in Minority Youth
-- Note: article touches on social differences, medical differences, the fact that minority children have more health conditions, but does not go into dietary differences, different exposure to heavy metals (the chemicals, not the music) etc. It's also alarming that teachers identify almost 40% of African American students as having ADHD, and over 14% of Caucasians as having it. Both numbers are scary - is this an edidemic? Or are we doing something terribly wrong TO these children through their environment or diet?
Oral health status, salivary flow rate and salivary quality in children, adolescents and young adults with ADHD
* dental. Children with ADHD taking meds have less saliva and higher plaque but not enough difference to cause more caries
Attention deficit hyperactivity disorder (see comment by Anthony 1999)
An auditable protocol for treating attention
deficit/hyperactivity disorder
- considers oligoantigenic diet okay as last resort; says not to bother with Feingold or glute/casein free diets.
The effect of thiamin tetrahydrofurfuryl disulfide on behavior of juvenile DBA/2J mice
Reporting of MMR evidence in professional
publications: 1988–2007 (related to Wakefield trial)
A 90 day Oral Toxicity Study of Tartrazine, a Synthetic Food Dye, in Wistar Rats
*Rats, tartrazine, yellow 5, food dye, food color, Sulfanilic acid (metabolite), liver, lung, stomach weights increase, kidney weight decrease, glucose, creatinine, cholesterol, triglecerid/triglycerides increase, hepatotoxicity, nephrotoxicity, dose response, fatty deteneration of liver, tubular degeneration of kidney, atrophy of glomerulus, RBC shape change. Conclusion quote: "There it is necessary that people should be aware about the hazardous effects of consuming Tartrazine." Himri, Bellahcen, Souna, Belmekki, Aziz, Bnouham, Joheir, Berkia, Mekhfi, Saalaoui. Morocco.
The management of hyperkinetic children: a trial of dietary therapy
The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a
randomised, double-blind, placebo-controlled clinical trial
* Japan. adhd, memory, children, phosphatidylserine supplement improved symptoms
Phenolic Compounds in Food: An Overview
*Polyphenol, antioxidants, tocopherols
The Criminal Victimization-Depression Sequela: Examining the Effects of Violent Victimization on Depression With a Longitudinal
Propensity Score Design
Assessment of food chemical intolerance in adult asthmatic subjects
Is Tourette’s syndrome an autoimmune disease?
Is there potential for the treatment of children with ADHD beyond psychostimulants?
* diet, ritalin, review of studies, alternative treatments
PHTHALATES - DEHP, bis(2)-ethylhexyl phthalate, alters gene expression in human cells: possible correlation with initiation of fetal
developmental abnormalities
Sudden Infant Death Syndrome - Letter to the Editor
The effect of the Feingold diet on 'normal' school children
Behavioural hyperactivity in rats following postnatal exposure to sub-toxic doses of
polychlorinated biphenyl congeners 153 and 126.
Behavioural effects in female rats of postnatal exposure to sub-toxic doses of polychlorinated biphenyl congener 153
*PCB, human milk, rats, behavior, Holene, Nafstad, Skaare, Krogh, Sagvolden, Norway
Depression: the nutrition connection
* Sugar, amino acids, tryptophan, women, catecholamine deficiency, phenylalanine, B vitamins, TMG, SAMe, B12, Folate, zinc, homocysteine, methionine, glutathione, genes, mood-boosting fats, omega 3, diet.
An hour less sleep is a risk factor for childhood conduct problems
*adhd, sleep, behavior, children, Holley, Hill, Stevenson, Southampton, UK
Oral provocation tests with aspirin and food additives in asthmatic patients
*Asthma, bronchoconstriction, urticaria, Hong, Park, Lee
Sensory Characteristics and Cross-Cultural Consumer Acceptability of Bulgogi
(Korean Traditional Barbecued Beef)
* Too bad - in order to be acceptable to American consumers, they will add more salt (soy sauce) and more sugar to their recipe
* Hong, Yoon, CHung, Chung, Cha, O'Mahony, Vicker, Kim. Korea.
Review Article
Methodological Issues and Evidence of Malfeasance in
Research Purporting to Show Thimerosal in Vaccines Is Safe
* Mercury, poisoning, allergy, Well'ssyndrome, developmental delay, adhd, autism. Hooker, Kern, Geier, Haley, Sykes, King, Geier.
Sublingual immunotherapy with a standardised grass pollen extract; a double-blind placebo-controlled study.
Effects of toluene on the wheel-turning activity and peripheral blood findings in mice - an approach to the maximum allowable concentration of toluene.
* All exposed mice - even 1 ppm - turned wheels less, red blood cells decreased, white blood cells increased.
* Currently 100 ppm allowed in workplace; should be lower. Horiguchi & Inoue. Japan.
Lack of Association between Measles Virus Vaccine and Autism with Enteropathy: A Case-Control Study
* Claims to replicate Wakefield's MMR study; results show no connection between MMR vaccine and
GI disturbance or MMV and autism
* See Uhlmann 2002, Krigsman 2010
* Hornig, Briese, Buie, Bauman, Lauwers, Siemetzki, Hummel, Rota, Bellini, O'Leary, Sheils,
Alden, Pickering, Lipkin
Autistic disorder and gastrointestinal disease
* "Treatment of the GI problems (eg, reflux, colitis, etc)
often has beneficial effects on the behavior of children with autistic disorder."
* GI symptoms, digestive disease, sleep disturbances, sudden irritability/aggression,
pancreatic enzymes, intestinal permeability, sulfation deficit in liver, histopathology of GI tract, Wakefield.
* Horvath, Perman.
Development and disability
Fragrances in oolong tea that enhance the response of GABAA receptors.
ADHD Is Associated With a “Western”
Dietary Pattern in Adolescents
Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment
* binary treatment: no effect. possible small benefits with continuous subjective outcomes for pain treatment.
* Hrobjartsson & Gotzsche. Denmark.
Salicylate intake and cardiovascular disease
Inhibitory Effects of Dietary Curcumin on Forestomach, Duodenal, and Colon
Carcinogenesis in Mice
* natural food dyes, cancer, curcumin, turmeric, mice. Huang, Lou, Ma, Newmar, Reuhl, Conney.
Study of skin rashes after antibiotic use in young children
* Children developed rash when given antibiotic when sick; not when well. When given dye-free antibiotic when sick, they were fine.
Toxic Effects of Sodium Fluoride on Reproductive
Function in Male Mice
Adverse drug reactions to antibiotic use in young children.
You asked for it. (Food for Thought).(Ritalin, bacteria, freeze-dried food, produce
washing, alcohol consumption)
Estimates of dietary exposure of children to artificial food colours in Kuwait
*diet, children, color additives, ADI, Husain, Sawaya, Al-Omair, Al-Zenki, Al-Amiri, Ahmed, Al-Sinan, Kuwait
Monosodium Glutamate Toxic Effects and Their Implications for Human Intake: A Review
* MSG. Husarova, Ostatnikova. Slovakia.
Supplementation of polyunsaturated fatty acids, magnesium and zinc in children seeking medical advice for attention-deficit/hyperactivity problems - an observational cohort study.
Neonatal Parenteral Nutrition Hypersensitivity: A Case Report Implicating Bisulfite Sensitivity in a Newborn Infant
Long-term dietary exposure to different food colours in young children living in different European countries
- SCIENTIFIC REPORT submitted to EFSA
Association Between Thimerosal-Containing Vaccine and Autism
* autism, mercury, says there is no connection, See commentary @ RIMLAND 2003. Hviid, Stellfeld, Wohlfahrt, Melbye
Institute for Agrigulture & Trade Policy: Smart Guide to Food Dyes
The Role of Ginger or Green Tea in Counteracting the Deleterious Effects of Benzene Sulfonic Acid in Weanling Male Rats
*Food dye, Sunset Yellow, Yellow 6, degrades to benzene sulfonic acid sodium salt (BSA) in light. Green tea, ginger modify liver damage in rats. Concluding quote: "It is recommended that synthetic coloring agents and food additives should be excluded from foods which may be consumed by young children." Ibrahim, Saleh, El-Shinnawy, Egypt.
Hazardous child labor: Lead and neurocognitive development
* "Overview of the extent of hazardous lead exposure in child laborers, as a model for effects of more numerous,
but less studied, substances."
* Neurotoxic effecs of lead on children / Occupational exposure of children to lead.
* Nutrition and child labor; Environmental exposures
* Understanding the potential costs of lead exposure to children.
* Ide, Parker. Ethiopia.
Changes in blood-brain barrier permeability during hot water-induced seizures in rats
* rats, hot water, seizures, BBB. Ilbay, Sahin, Ates. Turkey
ILSI 2001 - see Toxicology
Effects of color stimulation on handwriting performance of children with ADHD without and with additional learning disabilities (not related to diet, but is most interesting as another alternative that may help some)
Multiple Chemical Sensitivities Following Intolerance to Azo Dye in Sweets in a 5-year-old Girl
*Artificial food dye, food color, child, MCS, food additives, tartrazine, aspirin, Inomata, Osuna, Fujita, Ogawa, Ikezawa
Monosodium glutamate (MSG) intake is associated with the prevalence of metabolic syndrome in a rural Thai population
*MSG, diabetes, obesity, Thailand
Different Fates of Alzheimer?fs Disease Amyloid.?À Fibrils Remodeled
by Biocompatible Small Molecules
*Red 3, Blue 1 & Methylene Blue being tested on brain amyloid fibrils - possible future treatment for Alzheimer's; Blue 1 for treatment of MS & spinal injury; pass blood brain barrier.irwin
Pellagra among chronic alcoholics: clinical and pathological study of 20 necropsy cases [autopsies]
* They had pellagra without skin lesions and the diagnosis had been missed. Ishii & Nishihara. Japan.
Experimental Investigation on the Pathogenesis of Tartrazine-Induced Asthma
* Yellow 5 potentiates bronchonstriction effects of other bronchoconstrictors. Isihara, Kitamura. Japan.
Microscopic Studies of the Effect of Some Food Additives on the Kidney of Albino Rat
*Rats, food dyes, food coloring, sodium nitrate, Yellow 6, sunset yellow, kidney, liver enzymes, "The lumen of renal tubules ... becomes dilated with degeneration of its cells." 1 mg/kg/day Yellow 6 causes "many areas of cellular infiltrations" leading to "glomerulo-nephritis and interstitial nephritis."(US ADI is 3.75 mg/kg/day). Ismail, Moustafa, El-Rhman, Egypt.
Modifying Effects of Antioxidants on Chemical Carcinogenesis.
Attention-Deficit/Hyperactivity Disorder in Childhood Is Associated with Cognitive Test Profiles in the Geriatric Population but Not withMild Cognitive Impairment or Alzheimer’s Disease
Genotoxicity Assessment of Amaranth and Allura Red Using Saccharomyces Cerevisiae
* No DNA damage to bakers yeast at 28oC ... but significant DNA damage at 37oC ... authors conclude that "heavy concentration of food colors should be avoided in baking products" ... but what about human beings? OUR body temperature is 37oC
Arsenic, Organic Foods, and Brown Rice Syrup
* Baby formula, Nature's One, See eNews article
Arsenic concentration and speciation in infant formulas and first
foods.
* Baby formula, Nature's One, See eNews article
Intellectual impairment in children exposed to polychlorinated biphenyls in utero.
* infants, children, prenatal exposure only slightly higher than general population.
* IQ, memory, attention, reading all lower than normal at 11 years.
Prenatal exposure to polychlorinated biphenyls and attention at
school age.
Color us worried: Why synthetic food dyes should be banned.
* Nutrition Action Health Letter; good article to share. Jacobson, Kobylewski, CSPI.
Respiratory Manifestations of Food Allergy
*Food allergy, inhalation, asthma, otitis media
Patent application: Method for dyeing protein articles of food, especially protein casings
Acetylsalicylate and salicylates in foods
- claims Swain is all wrong and that levels are so low they cannot cause problems.
The Impact of Emissions from Structures on Indoor Air Concentrations in Newly Finished Buildings Predicted and On-Site Measured Levels
Hazards of heavy metal contamination
Old Versus New Medications: How Much Should Be Taught?
Fluoride and arsenic exposure impairs learning and memory and decreases mGluR5 expression in the hippocampus and cortex in rats
* IQ, retarded, child development, water, learning, memory, glutamate, hippocampus, cortex.
* Jiang, Su, Yao, Zhang, Cao, Wang, Wang, Li, Xi. China.
Tailored Additive Release Rates In Extruded Plastic Films Produced With Smart Blending Machines
Impaired Mitochondrial Dynamics and Nrf2 Signaling Contribute to Compromised Responses to Oxidative Stress in Striatal Cells Expressing Full-Length Mutant
Huntingtin
* Huntington disease, mitochondria, oxidative stress. Jin, Yu, Gundemir, Jo, Cui, Tieu, Johnson
Analyzing the Sensory Characteristics and Taste-Sensor Ions of MSG Substitutes
* MSG, yeast extract, hydrolyzed yeast extracts
* "A rose by another name ..."
* Jo, Lee
A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic
*BHA, estradiol, estrogenic, phthalate, Jobling, Reynolds, White, Parker, Sumpter, UK
Pharmacotherapy for Adolescent Obesity:
A Weighty Issue
- gastrointestinal lipase inhibitor,
The effect of the antioxidants, butylated ydroxy anisole, butylated hydroxy toluene and propyl gallate on growth, liver and serum lipids and serum sodium levels of the rat
* BHT, BHA increase lipid content of the liver and raise cholesterol. Johnson & Hewgill. Australia.
Health aspects of food additives
Drugs, dialogue, or diet: Diagnosing and treating the hyperactive child
* Says meds often help even if cause is dietary. Meds may conceal a food sensitivity, but author thinks the only way to find out is to withhold meds & give a 4-day fast (!!!). He comments children "do not like the Feingold diet" based on the Gross 1987 study
Attention-Deficit/Hyperactivity Disorder: Is it Time to Reappraise the Role of Sugar Consumption?
*Excessive sugar may lead to disruption of dopamine function, Johnson, Gold, Ishiimoto, Lanaspa, Zahniser, Avena.
Parents’ Beliefs About ADHD: Implications for Assessment and Treatment
* Author puts diet effect on ADHD into "false beliefs"
Dietary Chemicals and Brain Function
The Metabolism and Excretion of Tartrazine in
Rat, Rabbit and Man
The physiology and management of childhood asthma
* Interesting for history of asthma treatment - disodium cromoglycate (Intal), steroid, ACTH, psychiatry.
* Diet or additives not mentioned.
Prevalent Vitamin B-12 Deficiency in Twelve-Month-Old Guatemalan Infants Is Predicted by Maternal B-12 Deficiency and Infant Diet
Fighting Disease With Fruit
*Aboriginal health, nutrition, Australia, otitis media, ear infections, children, hearing, deficiency, vitamin C, iron
Appraisal of 4 Months' Consumption of Nutrient-Dense Foods within the Daily Feeding Pattern of Frail Elderly
Fish Oil Supplementation of Rats during Pregnancy Reduces Adult Disease Risks in Their Offspring
Supplementation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD)
* adhd, omega 3, ALA, no placebo group
Incidence of Intolerance to Food Additives
* urticaria, asthma, rhinitis, aspirin intolerance, salicylates, azo dyes, benzoates. BHT, BHA, annattohyperactivity (hyperkinesia). Sweden.
Recurrent urticaria: Clinical investigation of 330 patients
* asthma, urticaria, nasal polyps, migraine, arthralgia, psychiatric problems, GI problems, azo dyes, benzoates, BHT, BHA, sorbic acid, Yellow 10, carotene, canthaxanthine, annatto, nitrite. Sweden.
Sensory Characteristics and Consumer Acceptability of Beef Soup with Added Glutathione and/or MSG
* Glutathione (GSH), MSG, Jung, Hong, Kim. S.Korea.
Combined Effect of Mothers’ and Fathers’ Mental
Health Symptoms on Children’s Behavioral and Emotional Well-being
Do antidepressants cause suicidality in children?
A Bayesian meta-analysis
- they found an association, but concluded that they could not conclude causation
Laypeople’s viewpoints about the reasons for expert
controversy regarding food additives
Neighbourhood level and individual level SES
effects on child problem behaviour: a multilevel analysis
"Living in a more deprived neighbourhood is associated with higher levels of child problem behaviour, irrespective of individual level socioeconomic status."
Abnormal auditory forward masking pattern in the brainstem response of individuals with
Asperger syndrome
* hearing, autism, auditory processing, aspergers, schizophrenia, adhd. Kallstrand, Olsson, Nehlstedt, Skold, Nielzen. Sweden.
Poor black health, bad white attitudes
* Australian Aborigines, diet, vaccines, vitamins, health
Endotoxin and Vitamin C Part 1 – Sepsis, Endotoxin and Vitamin C
*endotoxin, bacteria, pathogens, Kalokerinos, Dettman, Meakin, Australia
Shaken Baby Syndrome: An Abusive Diagnosis
* Australia. Aborigines. Vitamin C, endotoxin, endotoxemia
B Vitamin Supplementation Reduces Excretion of Urinary Dicarboxylic Acids in Autistic Children.
The Potential Health Hazard of Tartrazine and Levels of Hyperactivity, Anxiety-Like Symptoms, Depression and Anti-social behaviour in Rats
Artificial food dyes and attention deficit hyperactivity disorder
- (Note: Dr. Kanarek assured me that Tufts U has no connection with them, but that the journal Nutrition Reviews itself is owned by the International Life Sciences Institute, an industry organization previously called the Nutrition Foundation.
Negligible Amelioration by Aluminium Sulphate on Subacute Fluoride-Induced Enzymatic
Alterations in Goats
Food dyes produce minimal effects on locomotor activity and vitamin B-6 levels in postweanling rats.
The relevance of food for children's cognitive and behavioural
health
* Review of food-behavior interactions.
* "In reality,
the accumulated evidence suggests that food affects behaviour in some children"
Dietary replacement in preschool-aged hyperactive boys
Children in Harm’s Way: Toxic Chemicals Linked to Developmental Disabilities
Editorial: Food Additives and Behavior: First Genetic Insights
* "Tomato Effect." Supplementation, Elimination, about the Bateman & McCann studies, polymorphism
A randomised controlled trial of the Neuro Emotional Technique (NET) for childhood Attention Deficit Hyperactivity Disorder
(ADHD): a protocol
*adhd, NET, Australia, Karpouzis, Pollard, Bonello
Interaction of Diazinon with DNA and the Protective Role of Selenium in DNA Damage
*insecticide, pesticide, DNA, genes, genotoxic, Kashanian, Gholivand, Ahmade, Ravan, Razi U, Iran
DNA Binding Studies of Tartrazine Food Additive
* Concluding, "this food colorant has a toxic potential to CT-DNA in vitri and it seems that it binds directly to DNA ... more attention should be paid to prevent our children from eating or drinking large amounts of food containing this colorant."
* Kashanian, Zeidali. Iran.
A Compound Herbal Preparation (CHP) in the Treatment of Children With ADHD: A Randomized Controlled Trial
* ADHD, TOVA, vitamins, food grade botanicals called Nurture & Clarity by Tree of Healing-LD Clinic, Herzliya, Israel.
* Katz, Levine, Kol-Degani, Kav-Venaki, Israel.
* Note: 3 of the authors work for Tree of Healing-LD which makes the product.
Evaluation of mutagenic potential of food dye (Apple green)
*Yellow 5, Blue 1, Ames test, salmonella, moderately mutagenic, Kaur, Arora, Katnoria
The efficacy of stimulant drug treatment for hyperactivity: A meta-analysis
* Reviewed 135 studies on drugs, most published in the 1970s, concluding stimulant drugs are effective for hyperactivity.
Hyperactivity and Diet Treatment: A Meta-Analysis of the Feingold Hypothesis
* Reviewed 23 studies, most published in the 1970s.
* Concluded that research has not validated the diet, which should be "questioned" as a treatment.
* This meta analysis is still quoted in spite of being 30 years out of date.
Maternal exposure to isobutyl-paraben impairs social recognition in adult female rats
* preservatives, social recognition behavior, autism, estrogenic chemicals
Adverse Behavioral Effects of Treatment for Acute Exacerbation of Asthma in Children:
A Comparison of Two Doses of Oral Steroids
* anxiety, aggression, hyperactivity. Kayani & Shannon.
Buckwheat protein extract suppression of the growth depression in rats induced by feeding amaranth (Food Red No. 2)
* rats, lowered cholesterol, constipation, fiber, Red 2 suppresses growth, buckwheat suppresses toxicity of Red 2, improved nutritional efficiency. Kayashita, Nagai, Kato. Japan.
Effects of food processing on pesticide residues in fruits and vegetables:
A meta-analysis approach
* Pesticides reduced or increased by blanching, boiling, canning, frying, juicing, peeling, washing
* Nice chart of pesticides found on various foods. Keikotlhaile, Spanoghe, Steurbaut. Belgium.
High Dietary Fructose Induces a Hepatic Stress
Response Resulting in Cholesterol and Lipid Dysregulation
Childhood Hyperactivity as a Predictor of Carotid Artery Intima Media
Thickness Over a Period of 21 Years: The Cardiovascular Risk in Young
Finns Study.
- Note - Question: Is the connection related also to sensitivity to additives? It would be interesting to do a longitudinal study of children on the Feingold diet to see if avoiding the additives affects the risk.
Food additives and hyperactivity:
Evidence supports a trial period of eliminating colourings and preservatives from the diet
Service needs of families with children with ADHD
Food Intolerance and the Food Industry
The Role of Diet in Acne and Rosacea
* Skin problems, rashes, diet, coffee, omega 3. Keri, Rosenblatt.
Evidence of toxicity, oxidative stress, and neuronal insult in autism.
* Purkinje cell loss, Purkinje cell physiology, atoxicity, oxidative stress.
* Heavy metals, Purkinje cell loss, and increased brain volume.
* Kern, Jones.
Sulfhydryl-Reactive Metals in Autism
* mercury, lead, arsenic, cadmium. theory of "poor excreters", glutathione levels low.
* higher antibiotic use - in rats, antibiotic destroys ability to excrete mercury.
* Kern, Grannemann, Trivedi, Adams.
Manganese Exposure from Drinking Water and Children’s Classroom Behavior in Bangladesh
Sodium Benzoate, a Metabolite of Cinnamon and a Food Additive, Upregulates Neuroprotective Parkinson Disease Protein DJ-1 in Astrocytes and Neurons
* mice, G protein, DJ-1, mevalonate metabolites, cns substantia nigra, genes. Khasnavis, Pahan.
Serum 25-hydroxyvitamin D, mortality, and incident cardiovascular disease, respiratory disease, cancers, and fractures: a 13-y prospective population study
* lowest risk total mortality was in concentrations over 90 mmol/L
Attention deficit/hyperactivity disorder (ADHD) in children: rationale for its integrative management Review
Autism, An Extreme Challenge to Integrative Medicine. Part I: The Knowledge Base
Autism, An Extreme Challenge to Integrative Medicine. Part II: Medical Management
Nutritional Status of Children with Attention Deficit
Hyperactivity Disorder: A Pilot Study
Do terbutaline- and mold-associated impairments of the brain and lung relate to autism?
Neurobehavioral and pulmonary impairment in 105 adults with indoor exposure to molds compared to 100 exposed to chemicals
Analysis of Polychlorodibenzo-P-Dioxins and Dibenzofurans (PCDDs/PCDFs) in Baked-Salt
Food Additives in Korea
* Dioxins in sea salt
* Kim, Kim, Ko, Son, Park. Korea.
Diet and asthma: looking back, moving forward
Aspartame-fed zebrafish exhibit acute deaths with swimming defects and
saccharin-fed zebrafish have elevation of cholesteryl ester transfer protein
activity in hypercholesterolemia
* Diet, Cholesterol, Artificial Sweeteners, Aspartame, Saccharin, Brain inflammation, swimming defects, Kim, Seo, Cho
Prevalence of Autism Spectrum Disorders in a Total
Population Sample
Correlation between attention deficit hyperactivity disorder and sugar consumption,
quality of diet, and dietary behavior in school children
- Note: This study ignores food dyes, considering only vitamins, fats, sugar, protein, calcium, as well as drinking habits and occupation (without details) of fathers. This in a country where other studies have already shown that children eat well over the ADI in several food dyes, and one in 38 kids has autism.
Simultaneous activation of salicylate production and fungal resistance
in transgenic chrysanthemum producing caffeine
Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents
Sugar and the Hyperactive Child
Diagnosis and management of attention deficit hyperactivity disorder in children
He admits parents are happy with the use of the Feingold diet, but downplays its usefulness. Note that he is affiliated with Massachusetts College of Pharmacy -
Table 1,
Table 2
Effects Of Dental Fluorosis And Salivary Contamination On Microleakage Of Four Different Restorative
Changes in Open-Field Activity and Novelty-Seeking
Behavior in Periadolescent Rats Neonatally Treated
with Monosodium Glutamate
* MSG, rats, neurobehavioral development, motor coordination, hyperactivity, hypoactivity
Rheumatoid arthritis treated with vegetarian diets
* Some patients benefit from fasting followed by vegetarian diet. Actually almost half the 27 patients with RA responded to diet.
Diet, Breakfast, and Academic Performance in Children
Children’s Dietary Recommendations:
When Urban Myths, Opinions, Parental Perceptions & Evidence Collide - Selected References
Health effects of Aspergillus in food and air
Psychological characteristics of people with perceived food intolerance in a community sample.
* They are more neurotic than normal, but not more so than the university's own staff.
* Knibb, Armstrong, Booth, Platts, Booth, MacDonald. UK.
Effect of a Dietary Intervention on Autistic Behavior
A screening method for the toxicity of food dyes using Artemia salina larvae.
* Xanthene food dyes inhibit lactate dehydrogenase activity.
* Kobayashi, Taniguchi, Sako, Takakuwa. Japan.
Toxicology of food dyes
* Kobylewski, Jacobson, CSPI
Environmental Toxicants and Developmental Disabilities: A challenge for Psychologists
* Brain development, developmental disability, adhd, behavior, toxin, toxic threat.
* Koger, Schettler, Weiss. U. of Rochester.
Pesticides in dietary foods for infants and young children.
* Current information "appears inadequate for a thorough scientific risk assessment"
* They propose maximum residue of 0.01 mg/kg in foods for infants because now 40% of those foods already are under this limit.
* Koletzko, Agett, Agostoni, Baerlocher, Bresson, Cooke, Decsi, Deutsch, Janda, Manz, Moya, Rigo, Socha. Europe.
The Relationship Between Whole Blood Serotonin and Repetitive Behaviors in Autism
*Children, Autism, self-injury, aggression, repetitive behavior, serotonin, Kolevzon, Newcorn, Kryzak, Chaplin, Watner, Hollander, Smith, Cook, Silverman.
Recent Developments in Low-Level Lead Exposure and Intellectual Impairment in Children
* 10 ug/dL - not low enough. However, social, school & parenting factors more important to cognitive function.
* Koller, Brown, Spurgeon, Levy. UK.
The influence of components of diet on the symptoms of ADHD in children
* importance of minerals, essential fatty acids (fish oil), food additives, salicylates. "Results of research suggest that food additives and salicylates may aggravate hyperactive behavior [in] children."
* Konikowska, Regulska-Ilow, Rozariska. Poland.
Carcinogenicity testing of food red No. 106 (Acid Red) in Rischer 344 rats.
* 2-year feeding study. Not carcinogenic. Konishi, Kitahori, Nishioka, Yane, Hiasa. Japan.
ADHD and iron deficiency
Neonatal Effects of Maternal Hypothyroxinemia
During Early Pregnancy
Girls With Social and/or Attention Deficits: A Descriptive Study of 100 Clinic Attenders
Cognitive Function of Children With Cystic Fibrosis:
Deleterious Effect of Early Malnutrition
Absence of Hyperactivity in Lead-Exposed Developing Rats
The Precautionary Principle in Environmental Science
* link between science and policy: definition, history, motivating factors, case illustrations ...
* Kriebel, Tickner, Epstein, Lemons, Levins, Loechler, Quinn, Rudel, Schettler, Stoto.
Clinical Presentation and Histologic Findings at Ileocolonoscopy in Children with Autistic Spectrum Disorder and Chronic Gastrointestinal Symptoms
* Autism, GI problems, vaccine. Krigsman, Boris, Goldblatt, Stott.
Mucosal reactivity to cow's milk protein in coeliac disease
Threshold of toxicological concern (TTC) in food safety
assessment.
The Threshold of Toxicological Concern Concept in Risk Assessment
- the "de minimis principle" for acceptance of chemicals "of unknown toxicity" as artificial flavorings.
Mental health needs of boys in secure care for serious or
persistent offending: a prospective, longitudinal study
White Matter in Liars
Do food additives cause hyperactivity in preschool children?
* Negative review of Bateman 2004 study.
International consensus statement on attention-deficit/hyperactivity disorder (ADHD) and disruptive behaviour disorders (DBDs): Clinical implications and treatment practice suggestions
* ADHD, DBD. Study sponsored by Johnson & Johnson.
* Treatment for ADHD = drugs & psych.
* Treatment for ADHD with CD (conduct disorder) = psych & drugs.
* Treatment for CD = psych & drugs "add on"
* Kutcher, Aman, Brooks, Buitelaar, van Daalen, Fegert, Findling, Fisman,
Greenhill, Huss, Kusumaker, Pine, Taylor, Tyano.
Blood brain barrier in right-and left-pawed female rats assessed by a new staining method
* adrenaline-induced hypertension destroys the BBB. Kutlu, Vatansever, Bayazit, Ekerbicer, Tan. Turkey.
Developmental neurotoxicity of industrial chemicals. - French
Erythrosin B inhibits dopamine transport in rat caudate synaptosomes.
Epidemiology of cough in relation to China
* air pollution, high fat diet
Nutritional therapies for mental disorders
Food additives (in baby food)
The Lancet’s policy on conflicts of interest
Prenatal Alcohol Exposure and Neurodevelopmental Disorders in Children Adopted From Eastern Europe
*Fetal alcohol syndrome, FAS, neurodevelopmental disorders, ADHD, developmental coordination disorder, mental retardation, cognitive impairment, alcohol in pregnancy, Landgren, Svensson, Stromland, Andersson Gronlund, Sweden
Protecting Children from Environmental Toxins: Toxicity testing of pesticides and industrial chemicals is a crucial step.
* Lead, mercury, PCB, tobacco, etc. children, behavioral problems, prenatal. Lanphear, Vorhees, Bellinger.
Attention-Deficit/Hyperactivity Disorder: A Preventable Epidemic?
*"therapeutic levels of methylphenidate ... are comparable to the concentrations in which the toxic effects of some environmental contaminants have been observed."
Early exposure to house-dust mite and cat allergens and development of childhood asthma: a cohort study
*infants, asthma, cat, Lau, Illi, Sommerfeld, Niggemann, Bergmann, Von Mutius, Wahn
Synergistic interactions between commonly used food additives in a developmental neurotoxicity test.
Combination of additives, food colorings, toxic to brain cells
Crime Times 2006
US findings of melamine-related renal disorders in Hong Kong children
* Melamine in milk, kidney damage, ulresound.
* Hong Kong children had less serious kidney damage with smaller kidney stones than Chinese children.
* Milk melamine concentration in China up to 2,563 mg/kg but only 68 mg/kg in Hong Kong.
* Lau, Wong, Ma, Kan, Siu.
Glutamate receptors, neurotoxicity and neurodegeneration
* excitotoxicity, MSG, Lau, Tymianski.
Arsenic-Mediated Activation of the Nrf2-Keap1 Antioxidant Pathway
* toxic, broccoli, tbhq, cancer. Lau, Whitman, Jaramillo, Zhang.
An (n-3) polyunsaturated fatty acid-deficient diet disturbs daily locomotor activity, melatonin rhythm, and striatal dopamine in syrian hamsters.
Holistic Treatment Approaches to ADHD: Nutrition, Sleep, and Exercise.
Urinary excretion of salicyluric and salicylic acids by non-vegetarians, vegetarians, and patients taking low dose aspirin.
Aspartame and its effects on health:
The sweetener has been demonised unfairly in sections of the press and several websites
- pro-aspartame article, begins in middle of page so scroll down
Chronic Toxicity of Environmental Contaminants: Sentinels and Biomarkers
*Toxic Chemicals, Fish Neoplasia, Cancer, Immunosuppression, Amphibians, Alligators, Steroid Hormones, LeBlanc, Bain
Maternal lron Deficiency Alters Essential Fatty Acid and Eicosanoid Metabolism and Increases Locomotion in Adult Guinea Pig Offspring
Drinking Water with Red Beetroot Food Color Antagonizes Esophageal
Carcinogenesis in N-Nitrosomethylbenzylamine-Treated Rats
*cancer, Ohio State, beetroot, esophageal cancer, rats, Lechner, Wang, Rocha, Larue, Henry, McIntyre, Riedl, Schwartz, Stoner
Estimates of the theoretical maximum daily intake of erythorbic acid, gallates, butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) in Italy: a stepwise approach
*BHA, BHT, Gallates, erythorbic acid, BHT intake above ADI in EU, LeClercq, Arcella, Turrini
Influence of Methylphenidate on Eating in
Obese Men
- new use for Ritalin
Feeding Problems in Children With Autism Spectrum Disorders : A Review
Association of serum concentrations of persistent organic
pollutants with the prevalence of learning disability and
attention deficit disorder
Proinflammatory T-cell responses to gut microbiota
promote experimental autoimmune encephalomyelitis
*MS, gut bacteria, immune system, mice, Lee, Menezes, Umesaki, Mazmanian
Effect of processed foods on serum levels of eosinophil cationic protein among
children with atopic dermatitis
* Allergy, diet for one week avoiding all processed foods. Dermatitis got improved, ECP (Eosinophil cationic protein) decreased.
* They also ate less calories. MSG is the presumed culprit, but all additives were eliminated for the one single week.
* Lee, Jim, Noh, Lee. Korea.
The Extent of Drug Therapy for Attention Deficit-Hyperactivity Disorder Among
Children in Public Schools
* adhd, prevalence of kids on meds in VA schools: 20% of White 5th grade boys
* LeFever, Dawson, Morrow.
Asthma: A modern perspective
* historical interest. "mysterious affliction about which little is known"
* Meltzer & the guinea pig. ß-adrenergic theory, prostaglandins,
Artificial Chemicals in Food: Additives in Modern Food
Meeting Report: Alternatives for Developmental Neurotoxicity Testing
* alternatives to animal testing protocols; TestSmart DNT; environmental health.
Lein, Locke, Goldberg
Behavioral Disinhibition Induced by Tryptophan Depletion in Nonalcoholic Young Men With Multigenerational Family Histories of Paternal Alcoholism
Morphometric analysis of mice uteri treated with the preservatives methyl,
ethyl, propyl, and butylparaben
* Parabens, preservatives, estrogenic changes in mouse uterus. See Ye 2006.
* Lemini, Hernandez, Jaimez, Franco, Avila, Castell. Mexico.
Risperidone Use in Autism Spectrum Disorders: A Retrospective Review of a Clinic-Referred Patient Population
- 50% improved; side effects a problem. Compare to diet improvement at ARI site
Arsenic Exposure Perturbs Epithelial-Mesenchymal Cell Transition and Gene Expression In a Collagen Gel Assay
*Heart, cancer, birth defects, gene alteration - upregulated, downregulated, sodium arsenite, cardiac toxicity, chicken embryos, abortions, Lencinas, Broka, Konieczka, Klewer, Antin, Camenisch, Runyan
Cardiac and behavioral evidence for emotional influences on attention in 7-month-old infants
The Physical, Developmental, and Mental Health Needs of Young
Children in Child Welfare by Initial Placement Type
Toxicants and Environmental Health: A Psychological Issue
* toxic exposure to chemicals and mental, neurolotical, reproductive health & cancer. Lesie, Koger.
The Fate of FD&C; Blue No. 2 in Rats
Remember the Endocrine System When Using
Psychoactive Drugs
Food, drug, and cosmetic dyes: Biological effects related to lipid solubility
- Note that they compared action of dyes with action of salicylate - previously determined to do the same thing.
Brain uptake of a food dye, erythrosin B, prevented by plasma protein binding.
Cold Comfort: Mothers, Professionals, and Attention Deficit Disorder
Hyperkinesis and Diet: A Double-Blind Crossover Trial with a Tartrazine Challenge
Note: Challenge was 5 biscuits per day, each containing ONE mg of Tartrazine, and then the children were tested the day AFTER completion of the challenge period.
Hyperkinesis and Diet: A Replication Study
Inorganic Lead Exposure in the Rat Activates Striatal cFOS
Expression at Lower Blood Levels and Inhibits Amphetamine-Induced cFOS Expression at Higher Blood Levels
Reactive oxygen-dependent DNA damage resulting from the oxidation of phenolic compounds by a copper-redox cycle mechanism.
* BHT, BHA, TBHQ, phenolic, acetaminophen
* "in the presence of copper, TBHQ induced extensive DNA degradation,
while BHA and BHT exhibited less DNA cleaving activites"
* Li, Trush.
Mercury intoxication presenting with tics
* case study, child, used herbal med Watermelon Frost, too many times a day. Li, Chan, Leung, Cheung, Lam, Fok. China.
Effects of High Fluoride Level on Neonatal Neurobehavioral Development
Preschool children's lead levels in rural communities of Zhejiang province, China.
* Blood testing 217 children for elevated lead levels. Li, Zhenyia, Lon, Hanyun
Development of an Ultrasensitive Immunoassay for Detecting Tartrazine
* Toxic effects, Yellow 5, food dye, haptens.
"The Junk Food Connection" A Study Reveals Alcohol and Drug Life Styles Adversely
Affect Metabolism and Behavior
* health hazard appraisal, cortisol, toxic metals, vitamin B12, sugar.
* Libby, Starling, Josefson, Ward.
Consumption of Soft Drinks and Hyperactivity, Mental Distress, and Conduct Problems Among Adolescents in Oslo, Norway
Acetaminophen Use During Pregnancy, Behavioral Problems, and Hyperkinetic Disorders
*Tylenol is a hormone disruptor, affects baby's brain development.
* Liew, Ritz, Rebordosa, Lee, Olsen. Denmark.
Scientifically Unsupported and Supported Interventions for Childhood
Psychopathology: A Summary
A very negative article, saying (in 2005) that there is no "methodologically sound support for the efficacy of the Feingold diet." Nor does he discuss any of it. But then, the author doesn't even know what the diet is, saying: [The Feingold diet] "is based on the assumption that salicylates contained in artificial food colorings and flavorings cause or contribute to ADHD."
Lead Exposure and (n-3) Fatty Acid Deficiency during Rat Neonatal Development Affect Subsequent Spatial Task Performance and Olfactory Discrimination
Aconitine intoxication mimicking acute myocardial infarction
- Chinese herb containing toxins
Assessment of Magical Beliefs about Food and Health
- good grief. See page 197: "However, whereas health-threatening impurities were previously assumed to originate mainly from witches, demons or women, among
others (Frazer, 1922/1963; Meigs, 1984), they are nowadays usually assumed to originate from such things as artificial additives, flavours,
colours, preservatives and environmental poisons (Hines, 1988)."
Hyperkinesis, Nutrition, and the Feingold diet
*ADHD, A strongly "negative" review, quoting Nutrition Fdn
Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide
dismutase.catalase mimetics
*Oxidative stress, antioxidants, cognitive deficits, Liu, Bi, Thompson, Doctrow, Malfroy, Baudry
Malnutrition at Age 3 Years and Externalizing Behavior
Problems at Ages 8, 11, and 17 Years
Report On The Intellectual Ability Of Children Living in High-Fluoride Water Areas
Dietary intake of lead and cadmium by children and adults – Result calculated
from dietary recall and available lead/cadmium level in food in comparison to
result from food duplicate diet method
* Toxins, subjects were on a "standard diet" and 24-hour recall was used.
* Liu, Wang, Song, Wu. China.
Haplotype-Based Study of the Association of Alcohol Metabolizing Genes with Alcohol Dependence in Four Independent Populations
*alcohol, ethanol, genes, Liu, Zhou, Hodgkinson, Yuan, Shen, Mulligan, Wang, Gray, Roy, Virkkunen, Goldman, Enoch
Gaultheria: Phytochemical and Pharmacological Characteristics
* 109 compounds, containing several salicylate derivatives. Used in herbal med for arthritis. Various chemical contents & structures discussed.
Fetal growth restriction is related to placental levels of cadmium, lead and arsenic but not with antioxidant activities.
The Role of Food Intolerance in Chronic Fatigue Syndrome
in The Clinical and Scientific Basis of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome", B.M. Hyde, J. Goldstein, and P. Levine, Editors. 1992, The Nightingale Research Foundation: Ottawa. p. 521-538
Dr. Lockey's Mayo Clinic Diet
* Original 1948, revised 1954, 1957, 1959, 1964, 1971, 1974, 1975, 1979, 1980.
Development and risk factors of juvenile antisocial behavior and delinquency.
* author suggests that increased antisocial, delinquent behavior, drug use, suicide, etc. is related to decreased levels of impulse control by US children.
Erythrosin B Inhibition of Neurotransmitter Accumulation by Rat Brain Homogenate
Colour Additives in Snack Foods Consumed by Primary School Children in Hong Kong
The Psychology of Education
* see page 334 Dietary Factors. Long, Wood, Littleton, Passenger, Sheehy.
Treatment of Autism Spectrum Children with Thiamine Tetrahydrofurfuryl Disulfide [the compound used for treating thiamine - Vitamin B1 - deficiency: A Pilot Study.
How Common is Autism?
Urinary metabolites of histamine and leukotrienes before and after placebo-controlled challenge with ASA and food
additives in chronic urticaria patients
The protective effect of farm milk consumption on childhood asthma and atopy: The GABRIELA study
* Asthma, raw milk, allergy
* Loss, Apprich, Waser, Kneifel, Genuneit, Buchele, ... von Mutius, Braun-Fahrlander
Chlorpyrifos exposure and urban residential environment characteristics as determinants of early childhood neurodevelopment
* organophosphate pesticides, poor neighborhoods, New York City
* Lovasi, Quinn, Rauh, Perera, Andrews, Garfinkel, Hoepner, Whyatt, Rundle.
Sweet Debate: Do artificial sweeteners contribute to rather than
combat obesity?
*Obesity, aspartame, sucralose, diet soda, mice
Organic Diets Significantly Lower Children's Dietary Exposure to Organiphosphorus Pesticides.
Salicylate, an aspirin metabolite, specifically inhibits the current mediated by glycine receptors
containing a1-subunits
Apigenin induces apoptosis in human lung cancer H460 cells through caspase- and mitochondria-dependent pathways
- chemical in vegetables & fruits
Toxicity of Food Drug and Cosmetic Blue No. 1 Dye in Critically Ill Patients
The Role of Natural Color Additives in Food Allergy
*Industry, Codex, food dyes, FDA
Fluoride Deposition in the Aged Human Pineal Gland
* by old age the pineal gland has accumulated F and the F/Ca ratio is higher than bone. UK
Does stimulant therapy help adult ADHD?
* Ritalin, drugs used as needed
Gut Microbiota, Probiotics, and Vitamin D: Interrelated Exposures Influencing Allergy, Asthma, and Obesity?
* microbiota, gut, allergy, probiotics, asthma, obesity, vitamin D
* Ly, Litonjua, Gold, Celedon.
News from the Biological Stain Commission No. 6
* Tartrazine, Yellow 5.
* Discussed recent studies; mentioned "continuing anxiety" over possible problems, but discounted "major health hazard"
* Lyon, Horobin. UK
Dietary exposure of secondary school students in Hong Kong to benzoic acid in prepackaged non-alcoholic beverages
* high consumers got 19.3% of ADI just from these drinks in school. 2 drink samples exceeded legal limit of benzoic acid.
* Author figures they are underestimating total exposure but that it is fine.
* Ma, Chan, Chung, Ho, Xiao. China.
Adverse reactions to food additives
Production of Polygalacturonases by Aspergillus Section Nigri
Strains in a Fixed Bed Reactor
* Orange juice, making enzymes from mold and peels for juice clarification
The Evaluation of the Genotoxicity of Two Commonly Used Food Colors: Quinoline Yellow (E 104) and
Brilliant Black BN (E 151)
*Food dyes, Micronucleus and Comet assays, genotoxic, Macioszek, Kononowicz.
Symptoms of narcolepsy in children misinterpreted as epilepsy
* Macleod, Ferrie, Zuberi. UK
Audiovisual hyperactivity disorder (AVHD):
a peril of the desire to excel
- If you have slogged through the other studies, you deserve to see this one - enjoy.
Environmental and Health Assessment of Substances in Household Detergents and Cosmetic
Detergent Products
*Fragrances, preservatives, solvents, surfactants, Madsen, Boyd, Nylen, Pedersen, Petersen, Simonsen.
Thimerosal and the Occurrence of Autism: Negative Ecological Evidence From Danish Population-Based Data
* Note 1: Thimerosal discontinued im 1992; autism continued to increase; aluminum and other changes or increases in toxic vaccine ingredients not addressed. Besides, thimerosal not removed from flu vaccines or others besides DPT- not mentioned.
* Note 2: Inpatient treatment was reported since 1969 but outpatient treatment only since 1995 (AFTER thimerosal discontinued) so it is not surprising that more cases of autism were reported - it is not usually a condition requiring inpatient treatment.
Note 3: It is remarked that the vaccines were changed gradually, and that the last shipment of mercury-laden vaccines was IN 1992 - therefore, even though on paper they no longer received such vaccines, in actuality they did.
MMR Vaccination and Autism: What is the evidence for a causal association?
* Autism, MMR
* Madsen, Vestergaard, Denmark.
* Concludes there is no scientific evidence of connection.
Brain drain: the cost of neglected responsibilities in evaluating cumulative effects of environmental chemicals
* adhd, 300 chemicals affect brain, calling for cumulative risk assessment of combination of chemicals, developmental disabilities, IQ point loss, BPA, pthalates, neurotoxicants.
* Maffini, Neltner
Effects of a pseudoallergen-free diet on chronic spontaneous urticaria: a prospective trial.
*Urticaria, allergy, food dyes, Magerl, Pisarevskaja, Scheufele, Zuberbier, Maurer
Migraine With Aura Triggered by Contact Lenses: A Case Report
Carcinogenicity of Aspartame in Rats Not Proven [see Soffritti]
Hyperactive-Impulsive Symptoms Associated With Self-Reported Sleep Quality in Nonmedicated Adults With ADHD
Toxic Effects of the Synthetic Food Dye Brilliant Blue on Liver, Kidney and Testes
Functions In Rats
*Blue 1, rats, 0.08 g/kg (80 mg/kg), (ADI=12 mg/kg) increased enzymes, decreased testosterone, congestion & hemorrhage in kidney. Testes, sperm damaged, renal failure. Egypt.
Zinc, Ferritin, Magnesium and Copper in a group of Egyptian Children with
Attention Deficit Hyperactivity Disorder
*ADHD, Mahmoud, El-Mazary, Maher, Saber
Exercise Responses in Boys With Attention Deficit/Hyperactivity Disorder: Effects of Stimulant Medication
Neonatal Jaundice, Autism, and Other Disorders of Psychological Development
* Risk lowest for mom's first baby, born between April & September & jaundiced,
* Risk highest for first baby, born between October and March & jaundiced.
* Maimburg, Bech, Vaeth, Moller-Madsen, Olsen, Denmark.
Biochemical and molecular basis of thimerosal-induced apoptosis in T cells: a major role of mitochondrial pathway.
* thimerosal (ethyl mercury thiosalicylate)depolarized mitochondrial membrane.
* induces apoptosis (death) in T cells by inducing oxidative stress & depleting glutathione via mitochondrial pathway.
* Makani, Gollapudi, Yel, Chiplunkar, Gupta.
Minding the Greens: Role of dietary salicylates in common behavioural health conditions
* ADHD, autism, diet. Malakar, Bhattacharya. Australia
The results of skin testing with food additives and the effect of an elimination diet in chronic and
recurrent urticaria and recurrent angioedema
*allergy, skin test, diet, Malanin, Kalimo, Finland
Changes in Pulmonary Adenosine Triphosphate-binding Proteins Detected by Nucleotide Photoaffinity Labeling following Treatment of Mice swith the Tumor-modulatory Agent Butylated Hydroxytoluene
* BHT, lung cancer, Malkinson, Haley, Macintyre, Butley
Quantitative trait loci that regulate susceptibility to both Butylated Hydroxytoluene-induced pulmonary inflammation and lung tumor promotion in CSB reccombinant inbred mice
* What's important here is to know that BHT has been used for many years to make - promote - induce - tumors in animals for cancer research. WHY is it still in our breakfast cereal?
Is sublingual immunotherapy clinically effective?
Systemic Absorption of Food Dye in Patients with Sepsis - letter to the editor
* Letter starts at bottom of page
* See picture of boy, page 2
Food Dye Use in Enteral Feedings: A Review and a Call for a Moratorium
* Blue dye used by 86% of ICU nurses & 91% ICU dietitians.
* No safety studies, no agreement on amount of dye to use; blue & green skin & urine
* Maloney, Ryan, Brasel, Binion, Johnson, Halbower, Frankel, Nyffeler, Moss.
Detection of aspiration in enterally fed patients: A requiem for bedside monitors of aspiration.
* Blue dye still used at that time in spite of safety concerns of absorption & toxic effects on mitochondria.
* Authors say dyes "should be abandoned" and use "nonrecumbent positioning" (sit them up).
Maloney & Ryan.
Latent Biases in Biocriminological Research
* History of biological explanations of criminal behavior, targeting marginalized and poor people.
Nutrition Therapy in Medical Practice
Changes in Emotions Related to Medication Used to Treat ADHD. Part I: A Literature Review - See Part II (Findling 2010)
Cadmium directly induced mitochondrial dysfunction of human embryonic kidney cells
The food contaminant semicarbazide acts as an endocrine disrupter: Evidence from an integrated in vivo/in vitro approach
* rats, estrogen, testosterone. Italy.
Epigenetic Manifestations in Diet-Related Disorders
* DNA methylation, silencing genes, amino acids, efa, fetal genome interacts with maternal nutrition, famine
Pediatric asthma: An integrative approach to care
- diet discussed but additives not mentioned
- bronchoconstriction discussed but not the food dyes.mark
* review of early studies; See Trites 1980 below.
* Trites did not use a Feingold-type diet, and used it for only 3 weeks on children newly off meds.
That ANY of them improved in that time is remarkable.
Evidence That Initial Obedient Killing Fuels Subsequent Volitional Killing Beyond Effects of Practice
Effectiveness of nutritional interventions on the functioning of children with ADHD and/or ASD. An updated review of research evidence.
Letter: Measurement of vitamin D3 metabolites in smelter workers exposed to lead and cadmium
* about Chalkley study. Chalkley replied. Connection of lead, cadmium, ferritin, etc.
Precipitating Factors in Asthma: Aspirin, Sulfites, and Other Drugs and Chemicals
*Asthma, anaphylactic, bronchospasm, propranolol, beta-blockers, Mathison, Stevenson, Simon
Aspirin Augments IgE-Mediated Histamine Release from Human Peripheral Basophils via Syk Kinase Activation
* Aspirin and food additives increase histamine release from mast cells and basophils, causing allergic symptoms. Benzoate, tartrazine, yellow 5, augmented histamine release. Important in urticaria, anaphylaxis, asthma. < Matsuo, Yokooji, Morita, Ooi, Urata, Ishii, Takahagi, Yanase, Hiragun, Mihara, Hide. Japan.
Effects of Artificial Food Colorings in Children with Hyperactive Symptoms
The Feingold Diet: A Current Reappraisal
Systemic lactose intolerance: a new perspective on an old problem
* Irritable bowel syndrome, hidden lactose, milk.
* Matthews, Waud, Roberts, Campbell
Suffer the restless children: the evolution of ADHD and paediatric stimulant use, 1900 - 80
* See pg. 454 Note #12. It is a quote from Conrad from 1974 and may be the best part of this article.
Allergy, learning, and behavior problems.
* allergic tension-fatigue syndrome, how to keep a food diary, etc.
Differential Oscillatory Electroencephalogram Between Attention-Deficit/Hyperactivity Disorder
Subtypes and Typically Developing Adolescents
* EEG different in adhd than in normal children
Estimates of the theoretical maximum daily intake of
phenolic antioxidants BHA, BHT and TBHQ in Brazil
*BHA, BHT, TBHQ, preservatives, oxidation, phenolic, dates of introduction, Maziero, Baunwart, Toledo, Brazil.
Prenatal and early postnatal dietary sodium restriction sensitizes the adult rat to amphetamines
Food additives and hyperactive behaviour in 3-year-old and
8/9-year-old children in the community: a randomised,
double-blinded, placebo-controlled trial
Consumption of soft drinks and other sweet drinks by WIC infants. - letter to the editor
* Health care workers should advise against giving soft drinks to babies. McCann, Baydar, Williams.
Mortality Associated with Attention-Deficit Hyperactivity
Disorder (ADHD) Drug Treatment: A Retrospective Cohort
Study of Children, Adolescents and Young Adults Using the
General Practice Research Database
*Stimulants increase suicide, not sudden death; McCarthy, Cranswick, Potts, Taylor, Wong
Efects of a very low-fat, vegan diet in subjects with rheumatoid arthritis
* 24 subjects, symptoms reduced.
McDougall, Bruce, Spiller, Westerdahl, McDougall.
Enzyme Potentiated Desensitisation (EPD)
A promising low-dose method of immunotherapy
Phenotypic variation in xenobiotic metabolism and adverse environmental response: focus on sulfur-dependent detoxification pathways
* "A significant number of individuals with environmental intolerance or chronic disease have impaired sulfation of phenolic xenobiotics ...impaired sulfation may be relevant to intolerance of phenol, tyramine, and phenylic food constituents, and it may be a factor in the success of the Feingold Diet." (sulphoxidation, see Scadding 1988)
Reporting Bias in Medical Research - A Narrative
Review
*McGauran, Wieseler, Kreis, Schüler, Kölsch, Kaiser
Lumps, Bumps, and Things That Go Itch in Your Office! - urticaria (hives)
(Govt Comparative Effectiveness Review) Attention Deficit Hyperactivity Disorder: Effectiveness
of Treatment in At-Risk Preschoolers; Long-Term Effectiveness in All Ages; and Variability in Prevalence, Diagnosis, and Treatment
Uncertainty analysis of the use of a retailer fidelity card scheme in the assessment of food
additive intake
* Food dyes, Yellow 6, McNamara, Mehegan, O'Mahony, Safford, Smith, Tennant, Buck, Ehrlich, Sardi, Haldemann, Nordmann, Jasti
*Note: These people are all from various Food Industry Giants. See SARDI 2010
*Note: They plan to solve their uncertainly problem with a math formula.
MCS = Multiple Chemical Sensitivity
EI = Environmental Illness
IEI = Idopathic environmental intolerance
Abstracts from the 26th Annual Meeting of the Society for Medical Decision Making
Abstracts Oral Presentations
What Doctors Don’ t Tell You. The Truth About the Dangers of Modern Medicine
Occupational contact dermatitis from tertiary-butylhydroquinone (TBHQ) in a
cutting fluid
*skin allergy, TBHQ, BHA, BHT
Reproductive Toxicology of Tartrazine (FD and C Yellow No. 5)
in Swiss Albino Mice.
Micronutrients Versus Standard Medication Management in Autism: A Naturalistic Case-Control Study
Mechanistic Basis for Inflammation and Tumor Promotion in Lungs of BHT-Treated Mice: Electrophilic Metabolites Alkylate and Inactivate Antioxidant Enzymes
Do or Decline? Comparing the Effects of Physical Inactivity on Biopsychosocial Components of Successful Aging
Sugar Substitutes and Your Health
Nutrition Review: Relationships of Nutrition With Depression and Anxiety
Trace Elements in Nutrition
Environmental factors associated with a spectrum of neurodevelopmental deficits.
*lead, mercury, neurobehavioral, cognitive, children, PCB, pesticide, smoke, alcohol, mental retardation, Mendola, Selevan, Gutter, Rice
Blood Lead Below 0.48 µmol/L (10 µg/dL) and Mortality Among US Adults
* Lower levels of lead still dangerous. Menke, Muntner, Batuman, Silbergeld, Guallar
Fluoride-Induced Resistance To Insulin In The Rat
The Relationship Between Behavior Ratings and Concurrent and Subsequent Mental and Motor Performance in Toddlers Born at Extremely Low Birth Weight
Behavioural and developmental effects of Butylated Hydroxytoluene (BHT) dosed to rats in utero and in the lactation period
*BHT, rats, developmental delay and hyperactivity in pups on BHT, more dead cells in brain
Effects of dietary protein and butylated hydroxytoluene on the kidneys of rats
*BHT, rats, Meyer, Kristiansen, Wurtzen, Denmark
Attenuation of the pulmonary inflammation response following butylated hydroxytoluene (BHT) treatment of cytosolic phospholipase A2 null mice
Note quotes:
- "Administration of BHT to mice causes lung damage ..."
- "Exposing mice to BHT causes reversible lung injury and inflammation. The model described more than 30 years ago has been used to study molecular mechanisms underlying ARDS (acute respiratory distress syndrome) and the chronic inflammatory state that characterizes chronic obstructive pulmonary disease and asthma."
In vitro studies on the role of collagen in the induction of hypersensitivity to flea bites
Case-control study of attention-deficit hyperactivity disorder
and maternal smoking, alcohol use, and drug use during
pregnancy.
Hypersensitivity Reactions to Food Colours with Special Reference to the Natural Colour Annatto Extract (Butter Colour)
* Annatto, Yellow 5 (Tartrazine), Yellow 6 (Sunset Yellow), Red 40 (Food Red 17), Red 2 (Amaranth), Ponceau 4, Red 3 (Erythrosine), Blue 1 (Brilliant Blue).
* Aspirin, sodium benzoate. Urticaria, angioedema. See Table 1. Mikkelsen, Larsen, Tarding. Denmark
Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD):
the potential role of epigenetic processes in mediating susceptibility
* dna, methylation, vitamins, folate, b12, b6, b2, choline
Cadmium induced-oxidative stress in pituitary gland is reversed by removing the contamination source
The Diet Wasn't Controlled
- letter in response to CONNERS 1976
Sensitivity to tartrazine
Concomitant Nonpharmacologic Therapy in the Treatment of Primary Nocturnal Enuresis
* nonpharmacological treatment of bed wetting, including diet.
Milestones Marking the Knowledge of Adverse Reactions to Food in the Decade of the 1980s.
Chemical sensitivity: Symptom, syndrome or mechanism for disease?
* MCS, chemical exposure, toxicant-induced loss of tolerance, environmental
Estrogenic Activity of Phenolic Additives Determined By an In Vitro Yeast
Bioassay
*Phenolics, sunscreen, preservative, flavoring, fragrance, estrogenic activity, yeast. Miller, Wheals, Beresford, Sumpter.
Thyroid-Disrupting Chemicals: Interpreting Upstream Biomarkers of Adverse Outcomes
*endocrine disruption, chemicals, Miller, Crofton, Rice, Zoeller
Liver Damage From Chronic Acetaminophen Dosing is Dangerous, But Not The Only Risk
* Fever, NSAID, vaccine, immune system, headache.
Fading Memories : Retrospective Recall Inaccuracies in ADHD
Affect Recognition in Adults With ADHD
Genomic Signatures Predict Migration and Spawning Failure in Wild Canadian Salmon
*Fish dying of diseases related to farmed fishes.
The Diet Factor in Attention-Deficit/Hyperactivity Disorder
*ADHD, Millichap, Yee, see comment on his review of Feingold diet
Provocations with perfume in the eyes induce airway symptoms in patients with sensory hyperreactivity
Adverse reactions to food additives: the extent and severity of the problem
*adhd, food intolerance, food additives, children, UK
Genetic variant of glutathione peroxidase 1 in autism
* under-transmission of the ALA6 gene and others cause glutathione to be low, so oxidative stress is high.
* combine this study with Dufault 2009 & 2012 studies.
* So it is already possible to identify at least some children genetically vulnerable who must be protected from
exposure to mercury in diet and vaccines - why are we ignoring that?
Depressed Mood Is a Factor in Glycemic Control in Type 1 Diabetes
* Effect of depression on glucose control
* Miranda, Van Tilburg, McCaskill, Lane, Edwards, Bethel, Feinglos, Surwit
Intriguing Gastrointestinal Properties of Bismuth: A Fold Remedy Brought Into the Realm of Clinical and Investigative Medicine
Plasma concentrations of dietary and nondietary antioxidants are low in severe asthma
*asthma, oxidative stress. Misso, Brooks-Wildhaber, Ray, Vally, Thompson
A unified web-based Query and Notification System
(QNS) for subject management, adverse events, regulatory, and IRB components of clinical trials
Toxicity of Xanthene Food Dyes by Inhibition of Human Drug-Metabolizing Enzymes in a NoncompetitiveManner
Forestomach Lesions Induced by Butylated Hydroxyanisole and Ethylene Dibromide: A Scientific and Regulatory Perspective
Meta-analysis of Vitamin D Sufficiency for Improving Survival of Patients with Breast Cancer
* Higher Vitamin D associated with lower mortality from breast cancer
Methanol: A chemical Trojan Horse as the root of the Inscrutable U
*Aspartame, formaldehyde, autism, multiple sclerosis, MS, Alzheimer's
"Tardive Photopsia" and the Tiel-Culemborg Study
- Notes: Letter to Ed re Fluoride; Tardive Photopsia = "delay in seeing the light"
Fluoride and Serum Cholinesterase
Note: Letter to the editor
The value of initial lactate in patients with carbon monoxide intoxication: in the emergency department
The efficacy of high doses of vitamin C in patients with paraquat poisoning
- pesticide poisoning
Confectionery consumption in childhoodand adult violence
Effect of salicylates in urticaria
* suggested causes: haptens, histamine, aspirin, sodium salicylate, phenyl salicylate. Moore-Robinson, Warin. UK
Integrating Environmental Justice and the Precautionary Principle in Research and Policy Making: The Case of Ambient Air Toxics Exposures and Health Risks among Schoolchildren in Los Angeles
Gestational Mercury Vapor Exposure and Diet Contribute to Mercury
Accumulation in Neonatal Rats
* rats, kidney, liver, mercury. Morgan, Price, Fernando, Chanda, O'Connor, Barone, Herr, Beliles.
* artificial butter, artificial flavoring, rats, mice. Morgan, Jokinen, Price, Gwinn, Palmer, Flake
Bronchial and Bronchiolar Fibrosis in Rats Exposed to 2,3-Pentanedione Vapors: Implications for Bronchiolitis Obliterans in Humans
Hair-element analysis - still on the fringe
* Morley & Ford. New Zealand.
Evaluation of research for usable knowledge in behavioral disorders: Ignoring the irrelevant, considering the germane.
* "Feingold Diet is close to a worthless behavioral and educational intervention." Mostert & Kavale.
An in vitro study of biological safety of condoms and their additives
Psychologists Knowledge and Perception of the Efficacy of Complementary and Alternative Therapy for Children with Attention-Deficit Hyperactivity Disorder
Prolonged use of the food dye tartrazine (FD&C; yellow nº5)
and its effects on the gastric mucosa of Wistar rats
A 14-Month Randomized Clinical Trial of Treatment Strategies for Attention-Deficit/Hyperactivity Disorder
The MTA at 8 Years: Prospective Follow-Up of Children Treated
for Combined Type ADHD in a Multisite Study
Alerting, Orienting, and Executive Attention in Children With ADHD
The influence of different food and drink on tics in Tourette syndrome
*TS, Tourette, caffeine, coffee, Coke, Muller-Vahl, Buddensiek, Geomelas, Emrich
European clinical guidelines for Tourette syndrome and other tic disorders. Part IV: deep brain stimulation
Restricted elimination diet for ADHD (correspondence)
*Criticism of Pelsser study; Mullins, Tang, Dear
Nocturnal enuresis and allergy
* Tested 2 groups for specific IgE allergens; soybean & hazelnut were the only ones different.
* Mungan, Seckiner, Yesilli, Akduman, Tekin. Turkey.
Effect of the Ketogenic Diet on the Activity Level of Wistar Rats
* diet decreased activity in animal ADHD model. Murphy, Likhodil, Hatamian, Burnham. Canada
The ketogenic diet causes a reversible decrease in activity level in Long–Evans rats
* diet decreased activity in animal ADHD model. Murphy, Burnham. Canada
An Exploratory Study of Postpartum Depression and Vitamin D
An inventory of European data sources for the long-term safety evaluation of methylphenidate
* Discussion of use of 13 European databases for use in future studies of long-term safety of Ritalin
Expanding Evolutionary Psychology: Toward a Better Understanding of Violence and Aggression.
- Note - unfortunately this 47-page document does not allow searches
Association of Tryptophan 2,3 Dioxygenase Gene
Polymorphism With Autism
Oxidant--antioxidant imbalance in asthma: scientific evidence, epidemiological data and possible therapeutic options (review)
Trajectories of boys' physical aggression, opposition, and hyperactivity on the path to physically violent and nonviolent juvenile delinquency.
* Monitored 1,037 boys from 6 to 15 for behavioral trajectories leading to specific delinquency types.
* Nagin & Tremblay
Sleep Well, Think Well: Sleep-Wake Disturbance in Mild Cognitive Impairment
A Vitamin Profile of Heroin Addiction
tert-Butylhydroquinone reduces lipid accumulation in C57BL/6 mice with lower body weight gain
* TBHQ, prevents weight gain by up-regulating ACOX1 gene expression
* causes elevated liver cancer risk and neoplasms in kidney (see Discussion)
Food intolerance and the irritable bowel syndrome
* 48.1% of 189 people with IBS got better on elimination diet.
* Dairy & grain most common.
- Notes:
- This was NOT the Governmental committee which has a similar name but actually didn't do anything.
- This committee was set up by the Nutrition Foundation, a food industry organization.
- See members of the Nutrition Foundation.
Survey of Industry on the Use of Food Additives 1977.
See the 4 pages on food colors here.
* Note - Average consumption of food dyes by top 1% of population = 327 mg/person/day.
* Note - Authors decided that had to be excessive so they divided the number by 5, no other reason given.
Arsenic Exposure and Type 2 Diabetes: A Systematic Review of the Experimental and Epidemiologic Evidence
* Arsenic interferes with glucose metabolism but study results are inconsistent; more research needed
*Navas-Acien, Silbergeld, Streter, Clark, Burke, Guallar
Lead Exposure and Cardiovascular Disease—A Systematic Review
Comparative Efficacy of Pomegranate Juice, Pomegranate Rind Powder Extract and BHT as Antioxidants in Cooked Chicken Patties
*Pomegranate better than BHT to preserve cooked chicken patties; Naveena, Vaithiyanathan, Babji, Kondiaiah.
Zinc status in HIV infected Ugandan children aged 1-5 years: a cross sectional baseline survey
The effect of sympathomimetic medication on cardiovascular
functioning of children with attention-deficit/
hyperactivity disorder (stimulant medications)
Examples
Zinc
B6
B12
B1
Nutrient intakes, vitamin-mineral supplementation, and intelligence in British schoolchildren
* Children 7 - 12 yrs recorded diets, then did double blind test w/vitamin. No differences.
* Nelson, Naismith, Burley, Gatenby, Geddes. UK.
* Suggest comparison of vitamins with Carlton 2000.
Conflicts of Interest in Approvals of Additives to Food Determined to Be Generally Recognized as Safe
Out of Balance
* GRAS, safety decided by additive manufacturer employees, no independent review, FDA
Food allergy and food intolerance: towards a sociological agenda
Sodium benzoate-induced repeated episodes of acute urticaria/angio-oedema: randomized controlled trial
* Sodium benzoate (E-211), hives, rashes, skin problems
* Only one patient had reaction to sodium benzoate alone -
but possible synergy with other ingredients not tested at all.
* Netis, Colanardi, Ferrannini, Tursi. Italy.
The Influence of Food Additives and Related Materials on Lower Bowel Structure and Function
Nutritional Intervention in ADHD
Heritable and Nonheritable Risk Factors for Autism Spectrum Disorders
NEWSPAPER/MAGAZINE ARTICLES:
Vasorelaxation induced by L-glutamate in porcine coronary arteries
* "glutamate induces a vasorelaxation that may be associated with symptoms seen in Chinese restaurant syndrome"
Diagnosis and management of attention-deficit/hyperactivity disorder in children, young people, and adults:
summary of NICE guidance
"Drug treatment should always be part of a
comprehensive treatment plan . . ."
The elimination of artificial colouring and additives
from the diet is not recommended as a generally
applicable treatment for children with ADHD."
Systemic Intracellular Bacterial Infections in Neurodegenerative and Benavioral DIsorders
Serum Cholinesterase Levels Elevated in Patients Suffering From ADHD
- Note: He says kids with ADHD have high cholinesterase and inhibiting it raises GABA so he advocates for use of anti-cholinesterase drugs such as alzheimer's drugs. But other studies show that pesticides and food additives LOWER cholinesterase which would make them a candidate treatment, but in animals this causes learning problems. Something is not kosher here.
A Preliminary Investigation of ADHD Symptoms in Persons with Celiac Disease
Association of Attention-Deficit/Hyperactivity Disorder and Celiac Disease: A Brief Report
Editorial: Where to with treatment for ADHD?
Meta-Analysis of Attention-Deficit/Hyperactivity Disorder or Attention-Deficit/Hyperactivity Disorder
Symptoms, Restriction Diet, and Synthetic Food Color Additives
*Food colors, ADHD, Nigg, Lewis, Edinger, Falk.
Restriction and Elimination Diets in ADHD Treatment
* Review of elimination diets; mention of Feingold diet with link, but then advises parents to try it alone, shopping the outside aisles, etc.
* Cautiously notes it may be worth it. Nigg, Holton
Consensus Development Conference: Defined Diets and Childhood Hyperactivity
NIH Consensus Development Conference
see page 6, "Some of the dietary elimination strategies showed intriguing results suggesting the need for future research." This is after more than 20 years of research, after Dr. L. Eugene Arnold had presented his review of all nonstimulant treatments under contract with them ... and he said that there are 8 convincing double blind studies that diet works.
Gene x Environment Interactions for ADHD: Synergistic Effect of 5HTTLPR Genotype and Youth Appraisals of Inter-Parental Conflict
*ADHD, serotonin, psychosocial distress
Effect of some flame-retardants on various cultured mammalian cells
* Testing chemicals on cells instead of animals to save money & time.
* HeLa cells, liver, kidney, brain and muscle cells similar to toxicity of mice or rats -
polynuclear cells, enlargement of cell & nucleus;
* DL1 cell lines more sensitive to flame retardants.
* Nishimura, Umeda, Ishizu, Momotani. Japan.
Exposure to Gestational Diabetes Mellitus and Low Socioeconomic Status: Effects on Neurocognitive Development and Risk
of Attention-Deficit/Hyperactivity Disorder in Offspring
*adhd, neurology, Nomura, Marks, Grossman, Yoon, Loudon, Stone, Halperin
Nutition Action: See CSPI
Evidence-based guidelines for management of attention-deficit/hyperactivity disorder in adolescents in transition to adult services and in
adults: recommendations from the British Association for Psychopharmacology
- Note - pg. 13 - "In terms of treatment, various dietary manipulations can improve ADHD symptoms in at least some children (Egger et al., 1985;
Carter et al., 1993; Boris and Mandel, 1994; Rowe and Rowe, 1994; Schmidt et al., 1997; Dykman and Dykman, 1998; Richardson and Puri, 2002 Ib), although the mechanism of these improvements is unknown."
Biomarkers of Methylmercury Exposure Immunotoxicity among Fish Consumers in Amazonian Brazil
* Mercury. Nyland, Fillion, Barbosa, Shirley, Chine, Lemire, Mergler, Silbergeld.
Monoamine activity reflected in urine of young patients with obsessive compulsive disorder, psychosis with and without reality distortion and healthy subjects: an explorative analysis
* OCD, schizophrenia, adrenalin, dopamine, serotonin. Levels of neurotransmitters abnormal in various mental illnesses.
* Oades, Ropcke, Eggers. Germany.
The development of conditioned blocking and monoamine metabolism in children with attention-deficit-hyperactivity disorder or complex tics and healthy controls: an exploratory analysis
* ADHD, Tourettes, dopamine, serotonin, MAO.
* ADHD positively correlated in TS but negatively in ADHD ... what about the kids with TS and ADHD?
* Oades & Muller. Germany.
Plasma neuropeptide-Y levels, monoamine metabolism, electrolyte excretion and drinking behavior in children with
attention-deficit hyperactivity disorder
* ADHD children drink more, urinate less, with different neurotransmitters & electrolyte excretion.
* Similarity to hypertension. Oades, Daniels, Rascher. Germany.
Differential measures of ‘sustained attention’ in children with attention-deficit/hyperactivity or tic disorders: relations to monoamine metabolism
* children, TS, ADHD, catecholamine, serotonin. Germany
Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia
* Review. Homocysteine is linked to neurodegenerative diseases and aging.
* Obeid, Herrmann. Germany.
Effect of Dietary Taurine Supplementation on GSH and NAD(P)-Redox Status, Lipid Peroxidation, and Energy Metabolism in Diabetic Precataractous Lens
* Glutathione & taurine low but supplementation does not raise to normal. Obrosova & Stevens.
Taurine Counteracts Oxidative Stress and Nerve Growth Factor Deficit in Early Experimental Diabetic Neuropathy
* Taurine counteracts oxidative stress in tissues & peripheral nerves.
* Obrosova, Fathallah, Stevens.
Effects of Nimodipine on Salicylate Ototoxicity
* Tinnitus, Ochi, Kinoshita, Nishino, Kenmochi, Ohashi, Japan
Blood lead in U.K. children - time for a lower action level?
* recommending action level go from 25 ug/dl to 10 ug/dl.
* Measure blood lead levels for children with anemia, pica, abdominal pain
* O'Donohoe, Chalkley, Richmond, Barltrop
Molecular Basis of Rotavirus Virulence: Role of Gene Segment 4
* bovine rotavirus, simian rotavirus given to mice, reassorted. Gene segment 4 determines dose needed.
* Offit, Blavat, Greenberg, Clark
Addressing Parents’ Concerns: Do Multiple Vaccines Overwhelm or
Weaken the Infant’s Immune System?
* He says that vaccines make babies healthier.
* Offit, Quarles, Gerber, Hackett, Marcuse, Kollman, Gellin, Landry.
Communicating science to the public: MMR vaccine and autism
*
Autism following MMR vaccine was by chance alone. Offit blames media and Wakefield. Offit & Coffin.
The meningococcal vaccine - public policy and individual choices.
* Risk 0.7 per 100,000 for adolescents & adults;
* vaccine not cost effective, not recommended by CDC, & not covered by insurance;
* Offit wants Advisory Committee on Imunization Practices & AAP to tell doctors to recommend parents pay for it.
* Offit & Peter
Meningococcal conjugate vaccine in the UK: an update
* UK immunized 90% infants & 85% adolescents in a year.
* Very safe vaccine but "no large studies of vaccine efficacy had been done."
* Effectiveness expected to be shown during use.
The Cutter Incident, 50 years later
* Salk polio vaccine by Cutter Lab - 40,000 children got polio;
* 51 paralyzed; 5 died. 113 family members paralyzed.
National Vaccine Injury Compensation Program VICP
thimerosal and vaccines - a cautionary tale
* Claims that the removal of thimerosal scared parents into thinking it must be unsafe.
* There is no study comparing safety of vaccines with and without thimerosal.
* This is a "cautionary tale of how not to communicate theoretical risks to the public."
Vaccines and Autism Revisited — The Hannah Poling Case
* "poorly reasoned." She had other fevers, ear infections, etc.
* And she wasn't autistic. She had mitochondrial enzyme deficit; similarity to autism "superficial."
The Problem With Dr Bob's Alternative Vaccine Schedule
* Reviews The Vaccine Book: Making the Right Decision for your child by Dr. Robert Sears
* Says his misrepresentation of vaccine science misinforms parents. Offit & Moser.
St.John's Wort for Depression
A high dietary intake of sodium glutamate as flavoring (Ajinomoto) causes gross changes in retinal morphology and function
* rats, MSG. Even the diet with "moderate excess" MSG caused retinal cell destruction.
* Ohguro, Katsushima, Maruyama, Maeda, Yanagihashi, Metoki, Nakazawa. Japan & US.
The Effect of Biological Treatment on Behavior and Communication of Children on the Autistic Spectrum
*ADHD, food additives, Israel
Effects of butylparaben on the male reproductive system in rats
* Preservatives, estrogenic, lowered testosterone and sperm count at ADI level.
Effects of butyl paraben on the male reproductive system in mice
* Preservatives, estrogenic, damages spermatogenesis, lowers testosterone at levels well below ADI. Japan.
Testosterone-Lowering Activity of Canola and Hydrogenated Soybean Oil in the Stroke-Prone Spontaneously Hypertensive Rat
The Effect of Nicotine on Developing Brain Catecholamine Systems
*Rats, Acetylcholine receptor, fetal central nervous system, CNS, neurotransmitter, brain, locomotor disturbance, dopamine, noradrenergic, neurons, Parkinson's, Alzheimer's, ADHD, nicotinic receptors, hyperactivity, Oliff, Gallardo.
Analysis of some industrial metals and ions in the cerebral cortex of goats in Nigeria
* Because they plan to mine minerals in Nigeria, they want to use the
goats to monitor environmental toxin levels.
* Nice explanation of toxicity of Fluoride, Nickel, Mercury, Arsenic, Cobalt.
* Olopade, Onwuka, Adejumo, Ladokun. Nigeria
Tourette Syndrome: Diagnosis, Strategies, Therapies, Pathogenesis, and Future Research Directions
Acute low dose monosodium glutamate retards novelty
induced behaviours in male swiss albino mice
* Injecting MSG into stomach of mice changes behaviors, indicating an effect on the brain,
the release of neurotransmitters including monoamines and GABA, and an effect on dopamine.
* Onaolapo & Onaolapo
Repeated Treatment with Haloperidol and Clozapine Exerts Differential Effects on Dye Coupling between Neurons in Subregions of Striatum and Nucleus Accumbens
* Dopamine, Onn & Grace.
onn
Fixed drug eruption to tartrazine
*allergy, food dye, tartrazine, Orchard, Varigos, Australia
Consideration of fluorescence properties for the direct determination of erythrosine in saffron in the presence of other synthetic dyes
* Method to detect erythrosine (Red 3) and other food dyes in saffron.
Ordoudi & Tsimidou. Greece
Enzyme and Sulphur Oxidation Deficiencies in Autistic Children with
Known Food/Chemical Intolerances
* Phenol-sulphotransferase-P, phenol-sulfotransferase-p, PST.
* Enzyme low in every child with autism and food/chemical intolerances.
* Enzyme needed to metabolize phenols and amines. Low PST causes buildup of serotonin, doopamine, noradrenaline
* octopamine, an inert neurotransmitter, can be created.
* Low sulfate (sulphate) - may not make enough, or may be using it up on unknown toxin.
* Test for PST with acetaminophen; gave children fever, low urine output, felt sick.
* O'Reilly & Waring. UK
Food sensitivity
* Letter to the editor, British Medical Journal (scroll down page to see)
* Salicylate intolerance, says that they are so ubiquitous they cannot be avoided
* He thinks avoiding tartrazine and benzoates probably caused improvements.
Prestimulation-induced Startle Modulation in Attention-Deficit Hyperactivity Disoider and Nocturnal Enuresis
* ADHD, enuresis. Ornitz, Hanna, Traversay
Neurodevelopmental outcome at early school age of children born to mothers with gestational diabetes
Changes in the Nutrient Content of School Lunches: Results from the
CATCH Eat Smart Food Service Intervention
* Sodium increased. No change in cholesterol, carbohydrate, protein, fiber, sugar, calcium, iron, and some vitamins.
* Calories reduced some, but still more than 1//3 RDA. Authors say total fat & saturated fat were reduced.
*Osganian, Ebzery, Montgomery, Nicklas,Evans, Mitchell, Lytle, Snyder, Stone, Zive, Bachman, Rice, Parcel.
Synthetic organic food colouring agents and their degraded products: effects on human and rat cholinesterases.
Contact urticaria from nickel and plastic additives (Butylhydroxytoluene, oleylamide
* allergy, BHT, BHA, Oleylamide, Denmark
The applicability of the ADI (Acceptable Daily Intake) for food additives to infants and children
* Author talks about vulnerability, higher metabolism in children, etc.
* does NOT talk about the blood brain barrier which is not fully developed in infants.
* Ostergaard & Knudsen. Denmark.
Risk Factors for Dental Fluorosis in a Fluoridated Community
Ethics Questions Raised by the
Neuropsychiatric, Neuropsychological, Educational, Developmental, and Family Characteristics of 18 Juveniles Awaiting Execution in Texas
The Danish State Veterinary Serum Laboratory: A review of past achievements and current activities
* Not really related to anything else on here but interesting what they were studying in 1968.
Aripiprazole in the Treatment of Irritability in Children and Adolescents With Autistic Disorder
* Autism, drugs, Owen, Sikich, Marcus, Corey-Lisle, Manos, McQuade, Carson, Findling
* Side effects (see Table 3) in 91.5% including drooling (8.5%), tremor (8.5%), vomiting (15%), fatigue (21%), etc.
* Placebo group had received far more previous psych-meds than aripiprazole group(p.1537)
Exposure to dogs and cats in the first year of life and risk of allergic sensitization at 6 to 7 years of age.
* asthma, allergens.
* Exposure to 2 or more (but not 1) dogs or cats reduces risk of getting allergies by about half.
* Ownby, Johnson, Peterson.
Nickel sulphate, food additives and seronegative arthritis: is there any
relationship?
Monosodium benzoate hypersensitivity in subjects with persistent rhinitis
* runny nose, sneezing, nasal blockage, can be triggered by additives including
Yellow 5, monosodium glutamate (MSG), monosodium benzoate, Red 3, sodium metabisulphite (sulfites)
* Pacor, Lorenzo, Martinelli, Mansueto, Rini, Corrocher. Italy.
Inattention, Hyperactivity, Impulsivity—Epidemiology and Correlations: A Nationwide Greek Study From Birth to 18 Years
School District Resources and Identification of Children With Autistic Disorder
Severe Airway Epithelial Injury, Aberrant Repair and Bronchiolitis Obliterans Develops after Diacetyl Instillation in Rats
* rats, popcorn lung, lung disease, toxins, artificial butter flavoring.
* Palmer, Flake, Kelly, Zhang, Nugent, Kirby, Foley, Gwinn, Morgan.
Effects of Orange II and Sudan III azo dyes and their metabolites
on Staphylococcus aureus
* These azo dyes do (and don't) inhibit growth of the bacteria.
* Some of the metabolites inhibited or completely stopped bacteria growth,
but authors conclude they have "no significant effects on cell viability of the bacterium."
* Pan, Feng, Cerniglia, Chen. See also PAN 2012
Evaluation of impact of exposure of Sudan azo dyes and their metabolites
on human intestinal bacteria
* Food dyes, carcinogenic, banned for food but used anyhow
DNA damage in human germ cell exposed to the some food additives in vitro
* Sunset Yellow (Yellow 6) and Brilliant Blue (Blue 1) were toxic to human sperm cells at amounts used in food
Peptidase Ensyme: Digestive Aid Project
* Bionostics, Inc. Autism Research Institute, ARI, Klaire Lab, natural supplement to break down gluteomorphin and casomorphin peptides
Play, ADHD, and the Construction of the Social Brain: Should the first class each day be recess?
Environmental and experimental exposure of phthalate esters: The toxicological consequence on human sperm
Nutrition and Pancreaticoduodenectomy
Formulation of a Medical Food Cocktail for Alzheimer’s Disease: Beneficial Effects on Cognition and
Neuropathology in a Mouse Model of the Disease
Fluorosis in a Wild Cotton Rat (Sigmodon hispidus) Population Inhabiting a Petrochemical Waste Site
Induction of Hepatic Tumors with Butylated Hydroxyanisole [BHA] in the Self-fertilizing Hermaphroditic Fish Rivulus ocellatus marmoratus
Sodium Salicylate Sensitivity in an Asthmatic Patient with Aspirin Sensitivity
* allergy, asthma, aspirin, tartrazine, Park, Suh, Cho, Korea
Aspirin-sensitive asthma: Recent advances in management
* Nasal polyps, salicylate, tartrazine (yellow 5), sodium bisulphite. Korea.
Effectiveness of Food Fortification in the United States: The Case of Pellagra
* "Results show the difficulty of evaluating the effectiveness of a single public health initiative such as food fortification without controlled experimental trials." Park, Sempos, Barton, Vanderveen, Yetley.
Dermatologic adverse reactions to 7 common food additives in patients with allergic diseases: A double-blind, placebo-controlled study.
Association between dietary behaviors and attention-deficit/hyperactivity disorder
and learning disabilities in school-aged children
* "... a high intake of sweetened desserts, fried food, and salt is associated with more learning,
attention, and behavioral problems ..."
* Not surprising, considering the food dyes and flavorings usually added to sweetened desserts,
and the MSG & flavorings added to salty fried foods (chips etc).
Nocturnal Enuresis Is Associated with Attention Deficit Hyperactivity Disorder and Conduct Problems
* Korea. bedwetting, adhd,encopresis, conduct disorder, adhd, comorbidity, "assess together"
Metabolic Fate of Food Colorants
The Safety of Aspartame
Management of Crystal Arthritis
Are Double-Blind Food Challenges Necessary Before Starting an Elimination Diet?
* Author is sure that eliminating milk or "cereals" would cause deficiencies
* Odd since most of human existence these were not eaten anyhow.
* Pastorello, Pravettoni, Stocchi, Bigi,Schilke, Zanussi.
A Comprehensive Approach to Treating Autism and Attention-Deficit Hyperactivity Disorder: A Prepilot Study
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Salicylic acid: a link between aspirin, diet and the prevention of colorectal cancer
* Salicylates, aspirin, cancer, Paterson, Lawrence, UK.
* Comparison of serum salicylate in vegetarians and people taking aspirin; why salicylates are healthy, if you tolerate them
Salicylates--it is not all bad news.(Research Briefs)
Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar, schizophrenia, and impulsive behavior
* all have common defect in serotonin regulation. Depression too.
Issues in the Formulation of Drugs for Oral Use in Children: Role of Excipients
* Starch, lactose, calcium salt, citric acid, sodium bicarbonate
* potassium bicarbonate, dextrose, cellulose, water, ethanol, alcohol, sucrose, sugar, glycerol, glycerin,
* sweeteners, natural, artificial, coloring, dyes. Pawar & Kumar
Collision or convergence?
Beliefs and politics in neuroscience discovery, ethics, and intervention
* Neurology. Paylor, Longstaff, Rossi, Illes. Canada
Food intolerance and Crohn's disease
* 48% identified food sensitivity but only 15% of those reacted to blind challenge (dose?) so authors say not worth it.
* Pearson, Teahon, Levi, Bjarnason.
Two double-blind placebo-controlled pilot studies of eicosapentaenoic acid in the treatment of schizophrenia.
* EPA (omega-3) essential fatty acid treatment was superior to DHA & placebo.
* Peet, Brind, Ramchand, Shah, Vankar. India.
Determination of Combined Benzidine in FD&C; Yellow No. 6 (Sunset Yellow FCF)
The Role of Recess in Children’s Cognitive Performance and School Adjustment
Complementary and Alternative Medical Therapies for Children with Attention-Deficit/
Hyperactivity Disorder (ADHD)
*ADHD, CAM, review, Pellow, Solomon, Barnard
A randomised controlled trial into the effects of food on ADHD.
ADHD as a (non)allergic hypersensitivity disorder: A Hypothesis
Effects of food on physical and sleep complaints in children
with ADHD: a randomised controlled pilot study.
Effects of a restricted eimination diet on the behaviour of children with attention-deficit hyperactivity disorder (INCA study): a randomised controlled trial
*See Mullins 2011 and Adesman 2011 for criticisms, and letter to Barkley. Lancet
Author's reply and correction for Lancet article
Letter to Barkley re his criticism of above study
ADHD, a Food-Induced Hypersensitivity Syndrome:
in Quest of a Cause: The effects of a restricted elimination diet (RED) on ADHD,
ODD and comorbid somatic complaints,
and a preliminary survey of the mechanisms of an RED
Restricted elimination diet for ADHD: the INCA study
A randomized controlled pilot study into the effects of a restricted elimination diet on family structure in
families with ADHD and ODD
* adhd, family environment, diet, Pelsser, van Steign, Frankena, Toorman, Buitelaar, Rommelse. Netherlands
Milk hypersensitivity - key to poorly defined gastrointestinal symptoms in adults
* Lactose intolerance common in adults. Milk hypersensitivity different & more common than thought in adults.
* Salminen, Lilius, Nuutila, Isolauri. Finland.
Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury.
Effectiveness of the gluten-free, casein-free diet for children diagnosed with autism spectrum disorder: Based on parental report
*autism, gfcf, diet, casein, gluten, children, food allergy, Pennesi, Klein, PA State U
Toxic effects of Ustilago maydis and fumonisin B1 in rats
* U. maydis is a fungus on corn called corn smut. Eaten in Mexico & used to induce labor. Chefs have tried to introduce it in US.
* fumonisin B1 is a atoxin produced by fusarium mold, mainly in corn, wheat, etc.
* Toxic to liver & heart, related to esophageal cancer.
* In study, rats eating the toxins were hyperactive. Showed "gross pathological changes in liver, lungs, uterus, and ovaries."
* Both showed neurotoxicity. Pepeljnjak, Petrik, Klaric. Croatia.
Free Radical Injury and Liver Tumor Promotion (BHT)
The Human Figure Drawing as Related to Attention-Deficit Hyperactivity Disorder (ADHD)
Aspirin and Salicylates Inhibit the IL-4- and IL-13-Induced Activation of STAT6
-- in his abstract, he says "the decreased use of aspirin has been hypothesized to contribute to the increase in childhood asthma." From the experience of Feingold members, this does not actually make sense, and we have a little trouble believing that the increase in asthma could be induced by an "aspirin deficiency." However, the study is very technical, and if someone reading this could explain it to me, I would appreciate it.
Asperger's syndrome: who is being abused?
* Case reports. Impact of kid's diagnosis on parents. Misdoagnosis of abuse in several. Perkins & Wolkind.
Primary school teachers’ knowledge and misperceptions of attention deficit hyperactivity disorder (ADHD)
* They claim that 65.2% of teachers "incorrectly believed that reducing dietary intake of sugar or food additives will effectively reduce the symptoms of ADHD"
* They quote Barkley extensively (he who has never actually done any research on ADHD and diet).
Perold, Louw, Kleynhans. S. Africa
Changing patterns of conditions among children receiving supplemental security income disability benefits.
* Chonic conditions increased 1989 to 1992, especially asthma & adhd. Perrin, Kuhlthau, McLaughlin, Ettner, Gortmaker.
Health effects of salicylates in foods and drugs
* Claims evidence for ADHD effect is "weak" but there is good info in here.
* Tables of salicylate amounts in drugs and various foods.
* Salicylate content of "Western" diet estimated at 10 -200 mg/day
* In decade from 1960 - 1970, additives increased salicylate exposure another 35 mg/day
* Perry, Dwyer, Gelfand, Couris, McCloskey
A Randomized School Trial of Environmental Strategies to Encourage Fruit and Vegetable Consumption among Children
Book: Chapter 3. Major Health Problems
(discussion of Stress)
CDC Update Whooping Cough Vaccine Recommendations
Sodium Lactate and Hypertonic Sodium Chloride Induce Equivalent Panic Incidence, Panic Symptoms, and Hypernatremia in Panic Disorder
* Large sodium load of hypertonic sodium chloride or lactate induces panic in panic disorder.
* Peskind, Jensen, Pascualy, Tsuang, Cowley, Martin, Wilkinson, Raskind.
Safety of ingestion of yellow tartrazine by double-blind placebo
controlled challenge in 26 atopic adults
Note: They don't see any problems with the Tartrazine, but then they only used 35 mg on adults and introduced even that in small increments over a 3-meal space of time.
Glutathione Conjugates of tert-Butyl-hydroquinone, a Metabolite of the Urinary Tract Tumor Promoter 3-tert-Butyl-hydroxyanisole, are Toxic to Kidney and Bladder
Best friends’ preference and popularity: Associations with aggression and prosocial behavior
Sodium cromoglycate as a replacement for inhaled corticosteroids in mild-to-moderate childhood asthma
* Sodium cromoglycate + terbutaline effective instead of steroid therapy.
* Petersen, Karup-Pedersen, Friis, Howitz, Nielsen, Stromquist. Sweden.
Vaccine adjuvants: Current state and future trends
* antigens, adjuvants, alum, Alzheimers, Th1, Th2. Petrovsky & Aguilar. Cuba, Australia.
Asthme et intolerance aux benzoates
* case study of girl with asthma found sensitive to bisulfite and sodium benzoate - when avoided, asthma relieved.
* Both additives had been in her asthma medicine. Petrus, Bonaz, Causse, Rhabbour, Moulie, Netter, bildstein. France
Efficacy of Vitamin B6 and Magnesium in the Treatment of Autism: A Methodology Review and Summary of Outcomes
*autism, vitamins, review, Pfeiffer, Norton, Nelson, Shott
Extent of Measles Virus Spread and Immune Suppression Differentiates between Wild-Type and Vaccine Strains in the Cotton Rat Model (Sigmodon hispidus)
* Viral spread, immune suppression, rat, spleen cells.
* Pfeuffer, Puschel, Meulen, Schneider-Schaulies, Niewiesk. Germany.
Phenol: DEVELOPMENTAL/REPRODUCTIVE TOXICITY DATA SUMMARY
California Office of Environmental Health Hazard Assessment.
Last date mentioned in this paper is 2002.
It seems to be filed with Prop.65 documents.
Website address:
http://oehha.ca.gov/prop65/CRNR_notices/state_listing/data_callin/pdf/phenoldatasum.pdf
Running Through the Generations
- selecting rats for speed may lead to new therapies for children with ADHD
Fetal programming of autonomic and HPA function: do people who were small babies have enhanced stress responses?
Report on Carcinogens, Twelfth Edition: Di(2-ethylhexyl) Phthalate
* DEHP, plasticizer in 40% of medical devices, 30% consumer goods, 30% construction apps;
* Used in pesticides, electric capacitors, to detect leaks in respirators, testing air filtration.
* Promoter of liver tumors in mice, detected in drinking water, ground-water, seawater, urine of exposed workers after shifts.
* Voluntary standard now that pacifiers, rattles, teethers "shall not intentionally contain DEHP."
Comparative Evaluation of Regenerative Capacity of Different Adsorbents and Filters for Degraded Frying Oil
Obesity: evolution of a symptom of affluence. How food has shaped our existence
*diabetes, insulin resistance, thrifty gene, Netherlands
Platelet serotonin 2A (5-HT2A) receptor characteristics and parenting factors for boys at risk for delinquency: a preliminary report
* Younger brothers of convicted delinquents living with abusive angry parents had less dense serotonin in platelet membrane
* Pine, Wasserman, Coplan, Fried, Huang, Kassir, Greenhill, Shaffer, Parsons
Role of Oxidants and Antioxidants in the Induction of AP-1, NF-kB, and Glutathione S-Transferase Gene Expression
Formation of a carcinogenic aromatic amine from an azo dye by human skin bacteria in vitro.
Asthma/Allergic Airways Disease: Does Postnatal Exposure to Environmental Toxicants Promote Airway Pathobiology?
The Reconstitution of Flavors
Diagnosis, Treatment, and Long-Term Outcomes of Late-Onset (Type III) Multiple Acyl-CoA Dehydrogenase Deficiency
Bioscience-bioethics and life factors affecting reproduction with special reference to the Indigenous Australian population
Survey of Colourings and Preservatives in Drugs
*Coloring, Food dyes, pharmaceutical, additives, Pollock, Young, Stoneham, Slater, Wilkinson, Warner
Effect of artificial food colours on childhood behaviour
* Used 125 mg mixed food dyes in capsules as the challenge.
Food additive intake and health effects: public health challenges in Brazil
Adverse health effects of air pollutants in a nonsmoking population.
* Utah, steel mill, respiratory, cardiovascular.
Tyrosine Supplements for ADHD Symptoms With Comorbid Phenylketonuria
* Letter to Editor, tyrosine helps ADHD w/PKU
Pediatric Neuropsychiatry and Neuropsychology (39 pages)
Academy of Psychosomatic Medicine (31 pages)
Rural children’s exposure to well water contaminants: Implications in light of the American Academy of Pediatrics’ recent policy statement
* private wells, testing, contamination, radon, arsenic, chromium, trichloroethylene, nitrates.
* Postma, Butterfield, Odom-Maryon, Hill, Butterfield.
The Artificial Food Dye Blues
First-Trimester Exposure to Methylphenidate: A Population-Based Cohort Study
* risk of major birth defects less than twice as much as no drug, so it is okay.
* Pottegard, Hallas, Andersen, Lokkegaard, Dideriksen, Aagaard, Damkier, Denmark.
Children’s relative age in class and use of medication for ADHD: a Danish Nationwide Study
* They found no age-connection to stimulant meds. But they also hold back younger children, and they only use any stimulant meds for 1.2% of children anyhow.
* Pottegard, Hallas, Hernandez-Diaz, Zoega. Denmark & Iceland
Medical and nonmedical stimulant use among adolescents: from sanctioned to unsanctioned use
Adolescent stimulant use
Dietary microparticles and their impact on tolerance and immune responsiveness of the gastrointestinal tract
Long-Term Treatment of ADHD With Stimulants: A Large Observational Study of Real-Life Patients
Practice Parameters for the Assessment and Treatment of Children, Adolescents, and Adults With Attention-
Deficit/Hyperactivity Disorder
"Dietary Interventions
Since the mid-1970s, the advocates of dietary treatment of behavioral problems have
been remarkably persistent (Rimland, 1983) despite the lack of scientific evidence. A
variety of food additives and food allergens have been proposed as contributory or even
causal in childhood hyperactivity. Reviews of the methodologically adequate studies
show that, at most, 5% of hyperactive children may show behavioral or cognitive
improvement on the additive-free Kaiser-Permanente or Feingold diets, but these changes
are not as dramatic as those induced by stimulants (Kavale and Forness, 1983; Mattes,
1983; Wender, 1986). The only characteristic associated with greater likelihood of
response is age less than 6 years. A small number of children may respond negatively to
tartrazine, a synthetic food dye (Rowe and Rowe, 1994). Parents and some primary care
practitioners find dietary treatment appealing because it is more "natural" than
medication, but special diets require extra work and often additional expense for a family that is already strained by a child's behavior problems. Considering
the minimal evidence of efficacy and the extreme difficulty inducing children and
adolescents to comply with restricted diets, dietary treatment should not be
recommended, except possibly with preschool children. Families who insist on trying a
diet should be permitted to do so, if the diet is nutritionally sound, because initial
attempts to dissuade them may disrupt the therapeutic alliance."
The 1997 practice parameter (American Academy of
Child and Adolescent Psychiatry, 1997) extensively
reviewed a variety of nonpharmacological interventions
for ADHD other than behavior therapy, including
cognitive-behavioral therapy and dietary modification.
No evidence was found at that time to support
these interventions in patients with ADHD, and no
studies have appeared since then that would justify
their use.
PRESTON 2005 -- see El Zein 2005
Height of primary school children and parents' perceptions of food intolerance
Genetic Polymorphism for Human Platelet Thermostable Phenol
Sulfotransferase (TS PST) Activity
* Inheritance (genes) control activity level and thermal stability of PST enzyme used for sulfate conjugation.
* Price, Spielman, Lucena, Van Loom, Maidak, Weinshilboum.
Associations of excessive irritability with common illnesses and food intolerance
Prenatal and infant exposure to thimerosal from vaccines and immunoglobulins and risk of autism
Dietary correlates of hyperactive behavior in children. (found link to sugar but not dyes)
Rebuilding relationships: A pilot study of the effectiveness of the Mellow Parenting Programme
for children with Reactive Attachment Disorder
Enzyme-potentiated desensitization (EPD) is back
Gluten-free diet may alleviate depressive and behavioural symptoms in adolescents with coeliac disease: a prospective follow-up case-series study.
Artificial food colorants inhibit superoxide production in differentiated HL-60 cells
Simian virus 40 transformation, malignant mesothelioma and
brain tumors
* polio vaccines, cancer, contaminated vaccines. Qi, Carbone, Yang, Gaudino.
What made Canada become a country with the highest incidence of inflammatory bowel disease: Could sucralose be the culprit?
* ulcerative colitis, crohn's disease, Splendaqin
Monosodium glutamate, a food additive, induces depressive-like and anxiogenic-like behaviors in young Rats
* MSG-treated rats are more susceptible to develop anxiogenic- and depressive-like behaviors,
which could be related to a dysfunction in the serotonergic system.
* Quines, Rosa, Da Rocha, Gai, Bortolatto, Duarte, Nogueira. Brazil.
Nutritional aspects of attention-deficit/hyperactive disorder (article in Spanish)
Dietary intervention for ADHD: a meta analysis
Article re new meta analysis admitting that diet "works" but with many caveats about
why it is not real useful .... note that it is supported by McNeal Pharmaceuticals
and Kurzweil Educational systems -- both benefit from ADHD financially.
Pharmacological and chemical effects of cigarette additives
* Tobacco, nicotine, acetaldehyde
The Examination of the Link Between Pesticides in Food and Learning Disorders in Children
Benefits of Periodontal Therapy When Preterm Birth Threatens
Disciplining domesticity: Framing the ADHD parent and child
* Details of how Feingold had mothers document behavior during diet implementationraf
Locks - a Key to Violence?
* Article about William Walsh, & Robert Thatcher; bio-behavioral research, chemical imbalance, criminal violence
* criminals high in lead, cadmium, iron, calcium, low in zinc; high sodium + low copper or
low sodium + high copper; low cobalt (needed for Vitamin B12)
* Barbara Reed, Schoenthaler featured in box
Effects of Environmental Enrichment at Ages 3–5 Years
on Schizotypal Personality and Antisocial Behavior at Ages 17 and 23 Years
Prevalence of Sensitivity to Food and Drug Additives in
Patients With Chronic Idiopathic Urticaria
* 100 patients, 11 additives including yellow 5, sulfite, MSG, aspartame, sodium benzoate, BHA, BHT, Yellow 6, nitrate, nitrite.
* only 2 had reactions.... antihistamines were used during time of challenge!!
* single blind screening: all additives at one time. Only 2 reacted.
* Double blind for these two: 1 additive at a time, and none reacted.
Hepatitis B: Infection, Vaccination and Autoimmunity
Food Additives and Sensitivities
* general information, see list of banned addtiives (Table 1) and food storage recommendations (Table 2)
* Rangan (Pediatric toxicologist, poison control), Barceloux (Medical toxicology - See his publications)
Active Ageing— Another Way to Oppress Marginalized and Disadvantaged Elders? Aboriginal Elders as a Case Study
Exposure assessment to synthetic food colours of a selected population in Hyderabad, India
* Food dyes - children eating more than ADI of tartrazine, sunset yellow and erythrosine (yellow 5, 6, red 3)
* Rao, Bhat, Sudershan, Krishna, Naidu, India
Role of vitamin B12 in depressive disorder — a case report
* vitamin; symptoms can include depression, apathy, irritability, dementia, catatonia, delirium, hallucinations
* Rao, Kumar, Raman, Sivakumar, Pandey. India.
Dextroamphetamine: Cognitive and Behavioral Effects
in Normal Prepubertal Boys
Diet and hyperactivity (re sugar, see page 3)
Pediatric psychopharmacology: too much or too little?
* ADHD, enuresis, depression, anxiety, OCD, psychoses; overtreated, stem cells, medications; "it is apparent that there was over-acceptance of drug treatment"
Effects of Environmental Enrichment at Ages 3–5 Years on Schizotypal Personality and Antisocial Behavior
at Ages 17 and 23 Years
Attention-Deficit/Hyperactivity Disorder and Methylphenidate: A dose-response analysis and
parent-child comparison of somatic complaints
Salicylate, A New Plant Hormone
* Description of activity of salicylate in plants. Ortho-hydroxybenzoic acid = salicylate
Bisphenol A in dental sealants and its estrogen like effect
*hormone disruptors, BPA. Rathee, Malik, Singh. India.
Allergic Fungal Sinusitis - a clinico-pathogical study
ADHD: A Psychological Response to an Evolving Concept :(Report of a Working Party of the British Psychological Society)
Red 3: Erythrosine - WHO Additives Series 19
* Note: Man given only 10 mg for 10 days = increase of protein bound iodine in blood; took 3 months to get back to normal.
* Food dye, IPCS Inchem, iodine, iodide, thyroid, rats, mice, man, mutagenic effect
EPA: Test Plan for Red 40
FEDERAL REGISTER: International Trade Commission, Allura Red Coloring from India - determinations
* US company complained that importing subsidized Red 40 cheaply from India would harm them (the company), but the anti-dumpling conference determined it was okay.
Scientific Opinion on the re-evaluation of Allura Red AC (E 129) as a food
additive
* By The International Association of Color Manufacturers/HPV Committee
Opinion of the Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers Concerning Basic Red 76
Reduced Red Blood Cell Membrane Essential
Polyunsaturated Fatty Acids in First Episode Schizophrenia at Neuroleptic-Naive Baseline
The possible role of peptides derived from food proteins in diseases of the nervous system
* gluten, casein, autism, schizophrenia, antibodies
The possibility and probability of a gut-to-brain connection in autism.
Peptides’ role in autism with emphasis on exorphins
* autism, gluten, casein, gliadin, peptides - if you aren't into technical info, go right to Page 6.
* Reichelt, Tveiten, Knivsberg, & Brønstad
A Condition Suggestion of Threshold Dental
Fluorosis Observed in Tristan Da Cunha
Synthetic Musk Fragrances in Human Milk from the United States
*Perfumes, deodorants, detergents, wildlife, environment, breast milk, musk xylene,Reiner, Wong, Arcaro, Kannan.
Magnesium Deficiency Modulates the Insulin Signaling Pathway in Liver but Not Muscle of Rats
*Rats, Brazil, insulin, rats, muscle, liver, insulin sensitivity, Mg deficiency improves insulin sensitivity?
Risk characterisation of chemicals in food and diet
* (61 pages), ILSI (successor to Nutrition Foundation, an industry organization)
* Page 1261-1262: list of participants, including several universities, institutes of public health, World Health Organization,
* AND: NutraSweet, Coca-Cola, Masterfoods, Red Bull, Proctor & Gamble, Ajinomoto, Unilever, Nestle, etc.
Food additives as a cause of medical symptoms: relationship shown between sulfites and
asthma and anaphylaxis; results of a literature review]
Placebo Adverse Events in Headache Trials: Headache as an Adverse Event of Placebo
Effect of organic synthetic food colours on mitochondrial respiration
(abstract only)
The Moderating Role of Sensory Overresponsivity in HPA (Hypothalamic Pituitary Adrenal Axis) Activity: A Pilot Study With Children Diagnosed With ADHD
Inner-City Availability of Preservative-Containing Albuterol
Exposure to Hexachlorobenzene during Pregnancy and Children's Social Behavior at 4 Years of Age
Amphetamine Treatment Similar to That Used in the Treatment of Adult Attention-Deficit/Hyperactivity Disorder Damages Dopaminergic Nerve Endings in the Striatum of Adult Nonhuman Primates
Behavioral effects of lead in monkeys tested during infancy and
adulthood.
Behavioral effects of lead: commonalities between experimental and epidemiologic data.
*lead toxicity, IQ, behavior, learning disability, adhd, Rice
Lessons for neurotoxicology from selected model compounds: SGOMSEC joint report.
*behavior, animals, lead poisoning, psychology, mercury, toxicity
Effects of postnatal exposure to a PCB mixture in monkeys on nonspatial discrimination reversal and delayed alternation performance.
Effects of postnatal exposure of monkeys to a PCB mixture on
spatial discrimination reversal and DRL performance.
Toxins resulting in behavioral effects
Behavioral impairment produced by low-level postnatal PCB
exposure in monkeys.
Toxins resulting in behavioral effects
Effects of postnatal exposure of monkeys to a PCB mixture on
concurrent random interval-random interval and progressive
ratio performance.
Parallels between attention deficit hyperactivity disorder and behavioral deficits produced by neurotoxic exposure in monkeys.
*adhd, hyperactivity, animals
Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
*Toxins resulting in behavioral effects, Rice, Barone
Methods and rationale for derivation of a reference dose for methylmercury by the U.S.EPA
*mercury, poisoning, neurological, neurotoxicity, Rice, Schoeny, Mahaffey
Behavioral Changes in Aging but Not Young Mice after Neonatal Exposure to the Polybrominated Flame Retardant DecaBDE
*polybrominated diphenyl ethers, mice, Rice, Thompson, Reeve, Onos, Assadollahzadeh, Markowski
Concentration of metals in blood of Maine children 1–6 years old
*lead, children, Rice, Lincoln, Martha, Parker, Pote, Xing, Smith
A randomized double-blind, placebo-controlled study of the effects of
supplementation with highly unsaturated fatty acids on ADHD-related
symptoms in children with specific learning difficulties
The Oxford-Durham Study: A Randomized, Controlled Trial of Dietary Supplementation With Fatty Acids in Children With Developmental Coordination Disorder
Omega-3 fatty acids in ADHD and related neurodevelopmental disorders
*brain, adhd, dyslexia, developmental coordination disorder, autism. fish oil
NIMH Collaborative Multisite Multimodal Treatment Study of Children with ADHD: 1. Background and Rationale
* Multimodal treatment study (MTA)
* Richters, Arnold, Jensen, Abikoff, Conners, Greenhill, Hechtman, Hinshaw, Pelham, Swanson.
Therapeutic doses of amphetamine and methylphenidate
selectively redistribute the vesicular monoamine transporter-2
* Differences in how amphetamine (Adderall) and methylphenidate (Ritalin) work.
* Riddle, Hanson, Fleckenstein. See also Sandoval 2002
Fetal Alcohol Spectrum Disorders: An Overview with Emphasis on Changes in Brain and Behavior
Comment on Ward's "Early Infantile Autism"
*See Ward 1970
Hair mineral analysis and behavior: An analysis of 51 studies.
* "Finally, although the original intent of this paper was to be descriptive rather than prescriptive,
we feel that our findings demonstrate the need for vigorous, biologically-based programs of
research on prevention and treatment."
* Rimland, Larson.
Brief Report: A Pilot Study of Auditory Integration Training in Autism
* Autism, AIT, Rimland, Edelson
* Results: "Thus, the experimental group showed a significant pattern of improvement over time for both the ABC and the FAPC criteria while the control group showed no significant change."
Brief Report: Alternative Approaches to the Development of Effective Treatments for Autism
* Autism, list of drugs used and responses, Rimland, Baker
Vitamin B6 in autism: the safety issue
* article Vol. 10 Autism Research Review International
What is the right 'dosage' for Vitamin B6, DMG, and other nutrients useful in autism?
* article Vol. 11 Autism Research Review International
High Dose Vitamin B6 and Magnesium in Treating Autism: Response to study by Ffindling et al.
* Autism, vitamins, see FINDLING 1997 - also see Findling's answer on page 2
Critique of "Efficacy of Vitamin B6 and Magnesium in the Treatment of Autism
* Comment on PFEIFFER 1995
Editorial: The Autism Epidemic, Vaccinations, and Mercury
Comments on “Secretin and Autism: A Two-Part Clinical Investigation” by M. G. Chez et al.
*autism, secretin
Vaccines and Autism
* Autism, vaccinations, mercury, MMR, Rimland, McGinnis
Commentary: Autism-Related Language, Personality, and Cognition in People with Absolute Pitch: Results of the Preliminary Study
*Autism, perfect pitch, comment on Brown 2003
Association between thimerosal-containing vaccine and autism
*Response to HVIID 2003 pointing out his affiliation with Statens Serum, maker of the vaccine under study, where vaccines are 80% of income
Some varieties of food intolerance in psychiatric patients: an
overview.
Validity of alternative allergy practices
Letter to the Editor re David studies
Organic mercury compounds: human exposure and its relevance to public health
- pg 118 - says kids got MMR with mercury in the Madsen study. MMR does not contain mercury.
Pellagra: Its symptoms and treatment
* Detailed description of symptoms. Suggestion it is related to "bad food."
* Quotes Dr. Celsus: "The part of the true physician is to go in and sit down beside the patient and chat for a few moments."
Food allergy and asthma - what is the link?
* Food can induce bronchospasm. Roberts & Lack. UK.
Salicylic Acid in Fresh and Canned Fruit and Vegetables
* salicylates, early study before Swain
Review: Tourette Syndrome, Associated Conditions and the Complexities of Treatment.
Food sensitivity and the nervous system: hyperactivity, addiction and criminal behaviour.
*
* Robinson & Ferguson. Scotland. Review of several studies.
enuresis in children with attention-deficit hyperactivity disorder
*ADHD, enuresis, bed wetting, Robson, Jackson, Blackhurst, Leung
*Concluding: "Physicians who treat patients with ADHD should routinely inquire about the presence of enuresis."
Psychopathology in Children with Epilepsy:
A Meta-Analysis
The effects of chronic methylphenidate administration on operant test battery
performance in juvenile rhesus monkeys
Vacuolation of Sensory Ganglion Neuron Cytoplasm in Rats with Long-term Exposure to Organophosphates - pesticides
Protecting Children from Chemical Exposure: Social Work and &.S. Social Welfare Policy
* asthma, leukemia, other diseases related to over 70,000 chemicals.
* protecting current and future generations from environmental contaminants.
Toxins, lead.
Rogge, Combs-Orme
Old and new controversies in the alternative treatment of attention deficit Hyperactivity disorder
*CAM, adhd, eeg, yoga, massage, homeopathy, sugar, food additives, food color, preservatives, Feingold, biofeedback, Rojas, Chan, Children's Hospital, Boston
Previous adult attention-deficit and hyperactivity disorder symptoms and risk of dementia with Lewy bodies: a case–control
study
*adhd, dementia, lewy body, dopamine, Alzheimer, Golimstok, Rojas, Romano, Zurru, DOctorovich, Cristiano, Argentina
Studies on the Mechanisms by Which Tumor Promoters Stimulate the Growth of Primary Neonatal Rat Hepatocytes"
Note: BHT is one of the "established tumor promoters" tested and found similar to the others.
Itches and Scratches - Is There a Link Between Eczema, ADHD, Sleep Disruption and Food Hypersensitivity?
Women and Depression: A Phytotherapist's Approach
Is there a future for restricted elimination diets in ADHD clinical practice?
* comment that if response to diet is placebo, it is the "largest and most dramatic placebo-effect documented thus far in ADHD research"
* Rommelse, Buitelaar, Heidelberg.
A follow-up study of patients with recurrent urticaria and hypersensitivity to aspirin, benzoates and azo dyes
* allergy, food dyes, salicylates, benzoates, urticaria, Ros, Juhlin, Michaelsson, Sweden
The Functional Relationship Between Artificial Food Colors and Hyperactivity.
Small double-blind study, carefully done - but they used only 1.2 mg food dye per day!!! and actually got results that they could see!!
Treating Food and Liquid Refusal in an Adolescent With Asperger's Disorder
Considering Cultural Diversity in the Management of ADHD in Hispanic Patients
*adhd, race, hispanic, ritalin
Inactivation of Brassinosteroid Biological Activity by a
Salicylate-inducible Steroid Sulfotransferase from Brassica napus
Food Sold in School Vending Machines Is Associated With Overall Student
Dietary Intake
* "Vending machines in schools was negatively associated with fruit consumption."
* "Schools are in a powerful position to influence the diets of children"
* Rovner, Nansel, Wang, Iannotti
Annotation: Food Additives
* Feingold diet, flavor, color, preservatives, hyperactive, adhd
Synthetic food colourings and "hyperactivity": a double-blind crossover study
Synthetic food coloring and behavior: a dose response effect in a double-blind placebo-controlled repeated measures study
Prevalence of medication treatment for attention deficit hyperactivity-disorder among elementary school children in Johnston County, NC
Action plan on food allergies and intolerances launched
New European ‘Network of Excellence’ to combat allergies
Successful treatment of OCD with a micronutrient formula following partial response to
Cognitive Behavioral Therapy (CBT): A case study
Nutrient supplementation approaches in the treatment of ADHD
* zinc, carnitine, pycnogenol, efa, vitamins, magnesium, iron, SAM-e, tryptophan, Ginkgo biloba
Successful treatment of bipolar disorder II and ADHD with a micronutrient formula: a case study
Database analysis of children and adolescents with Bipolar Disorder consuming a micronutrient
formula
Effect of Micronutrients on Behavior and Mood in Adults With ADHD: Evidence From an 8-Week Open Label Trial With Natural Extension
Vitamin-mineral treatment of attention-deficit hyperactivity disorder in adults: Double-blind randomised placebo-controlled trial
* adhd, micronutrient formula, vitamins, minerals, no omega 3
* Rucklidge, Frampton, Gorman, Boggs.
Comparative Toxicity of Food Dyes on Liver and Kidney in Guinea Pigs: A Histopathological Study
*Food dyes, carmoisine, tartrazine, yellow 5, guinea pigs, "congestion, perivascular and pericanalicular oedema," "hepatotoxic and nethrotoxic action, causing congestion, stasis and edema in the liver and kidney .... extension of lesions is largely proportional to dose." Rus, Gherman, Miclaus, Mihalca, Nadas. Romania.
Maladaptive Eating Patterns After Weight-Loss Surgery (Review)
Lateralisation of language function in young adults born
very preterm
Decreased Serum Hepatocyte Growth Factor (HGF) in Autistic Children with Severe Gastrointestinal Disease
* autism, GI disease, growth factor lower, Met gene.
* Russo, Krigsman, Jepson, Wakefield.
Low serum myeloperoxidase in autistic children with gastrointestinal disease
* autism, serum myeloperoxidase low, GI disease
* Russo, Krigsman, Jepson, Wakefield.
Treatment-Resistant Chronic Mental Illness: Is it Asperger's Syndrome?
* diagnosis
Hormone replacement therapy: The arrogance of preventive medicine
The effect of diet supplementation on children with ADHD
* case study
Attention-deficit/hyperactivity disorder and integrative approaches.
* Nice article about various natural treatments.
* Discussion of oligoantigenic (few foods) diet only; no mention of Feingold diet.
Acquired mitochondrial impairment as a cause of optic nerve disease
*blindness, neuropathy, Cuba, vitamin deficiency, methanol, cyanide, toxins
Investigations of In vitro Digestibility of Proteins Bound to Food Colors
Stimulant treatment in Maryland public schools.
* Surveyed students medicated during school hours. ADHD.
* Not included: children in private schools (17%), or taking meds only in morning.
* But they guessed they got 80% ... based on nothing much apparently.
Prenatal Organochlorine Exposure and Behaviors Associated With Attention
Deficit Hyperactivity Disorder in School-Aged Children.
Prenatal Exposure to Mercury and Fish Consumption During Pregnancy and Attention-Deficit/Hyperactivity Disorder–Related Behavior in Children
* prenatal mercury exposure leads to more ADHD behavior, but eating fish during pregnancy protects against it.
* Sagiv, Thurston, Bellinger, Amarasiriwardena, Korrick
A study on the toxicity of natural food dyes - toxicity and enzyme inhibition in Paramecium caudatum.
* in vitro testing was proportional to toxic effect on survival time of Paramecium caudatum.
* analysis failed to identify toxic components. See also Kobayashi 1977.
* Sako, Kobayashi, Taniguchi, Takakuwa. Japan.
Allergy testing, psychological assessment and dietary treatment of the hyperactive child syndrome
* allergy test, salicylates, food dyes, flavor, KP diet, Feingold diet, 93% improved.
* sleep, enuresis
Food allergy. Part 1: Immunopathogenesis and clinical disorders.
* asthma, gastroenteritis, rhinitis, celiac disease, dermatitis, urticaria.
Essential fatty acid requirements of vegetarians in pregnancy,
lactation, and infancy
* Long chain polyunsaturated fatty acids (LCPUFA)
Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome
Region, Are Strongly Associated with Autism
Methylphenidate Alters Vesicular Monoamine Transport and
Prevents Methamphetamine-Induced Dopaminergic Deficits
* "insight into the neurotoxic effects of methamphetamine but also mechanisms
underlying dopamine neurodegenerative disorders, including Parkinson’s disease"
* Sandoval, Riddle, Hanson, Fleckenstein.
Cat's claw inhibits TNF production and scavenges free radicals: Role in cytoprotection.
* Uncaria tomentosa, medical plants, anti-inflammatory, antioxidant.
* Sandoval, Charbonnet, Okuhama, Roberts, Krenova, Trentacosti, Miller, Rainforest Phytoceuticals.
Prevalence of autism spectrum disorders in relatives of patients with selective immunoglobulin A deficiency
* "screening for an ASD (autism spectrum disorder) sseems appropriate for children of IGA deficient patients."
* Santaella, Varela, Linares, Disdier.
Neurotoxic effects of polymorphonuclear granulocytes on hippocampal primary cultures
* inflammation, neurodegenerative, brain, rats.
* Dinkel, Dhabhar, Sapolsky.
Synthetic Food Colouring and Behavioural Change in Children with Attention Deficit Disorder: A Double-Blind, Placebo Controlled, Repeated Measured Study
Note: Only 10 mg food dye used as the challenge material.
Physiological changes in hyperactive children following the ingestion of food additives.
* food dyes, adhd, EEG, pulse, heart rate. Salamy, Shucard, Alexander, Peterson, Braud.
* Notes:
(1) only 4 kids in each group
(2) Red 40 only item tested -- in unknown amount
THE VITAMIN C CALAMITY: Plea To Re-Evaluate The RDA for Vitamin C
*cataracts, aneurysms, gallstones, cancer, heart disease, vitamin C
Use of retailer fidelity card schemes in the assessment of food additive intake:
Sunset Yellow a case study
*Food dye, Yellow 6, Sardi, Haldemann, Nordmann, Bottex, Safford, Smith, Tennant, Howlett, Jasti, ILSI Europe, Ajinomoto Europe, Unilever, Nestle, EFSA, etc.
*Most of the authors appear to be related to food industry giants
Role of house-dust mites in childhood asthma.
* mites found in mattresses not covered in plastic, in upholstered furniture, etc. They feed on human skin scales
Cinnamon Extract Improves Insulin Sensitivity in the Brain and Lowers Liver Fat in Mouse Models of Obesity
* diatetes, brain, obesity, glucose. Sartorius, Peter, Schulz, Drescher, Bergheim, Machann, Schick, Siegel-Axel, Schurmann, Weigert, Haring, Hennige. Germany.
The comet assay with 8 mouse organs: results with 39 currently used food additives
* mice, fod dyes, preservatives, fungicides, genotoxicity, amaranth (Red 2), allura red (Red 40), New Coccine, Tartrazine (Yellow 5, Erythrosine (Red 3), Phloxine, Rose Bengal, DNA damage. BHA, BHT, fungicides, sucralose, cyclamate, saccharin, DNA damage in GI. Sasaki, Kawaguchi, Kamaya, Ohshita, Kabasawa, Iwama, Taniguchi, Tsuda. Japan.
A Prospective Study of Delinquency in 110 Adolescent Boys with Attention Deficit Disorder and 88 Normal Adolescent Boys
A 30-Year Prospective Follow-up Study of Hyperactive Boys With Conduct Problems: Adult Criminality
* ADHD, adults, criminals, prison, IQ
* "An intensive 3-year MMT treatment of 6- to 12-year-old hyperactive boys is insufficient
to prevent later adult criminality"
* Satterfield, Faller, Crinella, Schell, Swanson, Homer.
Biochemical Assessment of the Nutritional Status of Vitamin B6 in the Human
Consumption Patterns of Artificially Coloured Foods Among Children in Kuwait
Note: See Page 158 (Results) which reports that "Data obtained showed that the average daily intakes of tartrazine, sunset yellow, carmoisine, and allura red as percentages of their ADIs, were, in all age groups, more than 100 per cent ..." These were averages, so while some of the kids obviously ate less, many probably ate much more than the ADI.
The efficacy of probiotics for monosodium glutamate-induced obesity: dietology concerns
and opportunities for prevention
* MSG. Savcheniuk, Virchenko, Falalyeyeva, Beregova, Babenko, Lazarenko, Demchenko, Bubnov, Spivak. Ukraine.
Adolescents with a chronic condition: challenges living,
challenges treating
Serological changes induced by blend of Sunset Yellow, Metanil Yellow and Tartrazine in Swiss Albino Rat, Rattus Norvegicus
* food dyes, colors, protein decrease, alkaline phosphatase increased
* Conclusion: prolonged consumption of the blend may cause adverse effect on human health. Saxena, Sharma. India
the modifying effect of selenium and vitamins A, C, and E on the genotoxicity induced by sunset yellow in male mice.
* Yellow 6, sperm abnormality, antioxidants, chromosomal aberrations, DNA.
* Sayed, Fouad, Ataya, Hassan Fahmy. Egypt.
Poor sulphoxidation ability in patients with food sensitivity
* asthma, migraine, arthralgia, irritable bowel, rhinitis, urticaria, hay fever, eczema,
delayed reactions, sulphoxidation index, carbocisteine.
* Scadding, Ayesh, Brostoff, Mitchell, Waring, Smith.
Biomarkers and Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analyses
* ADHD. Markers. Zinc, Neuropeptide Y, manganese, DHEA. Scassellati, Bonvicini, Faraone, Gennarelli.
Do artificial food colors promote hyperactivity in children with hyperactive syndromes? A meta analysis of double blind placebo-controlled trials
How efficacious and safe is shortacting
methylphenidate for the treatment of attention-deficit disorder in children and adolescents? A meta-analysis
Hyperactivity not linked to food additives
* Dated 1995, but written in 1981. Often quoted today as though no research has been done since then.
Epidemiology of contact allergy in adults
Effects of PCB Exposure on Neuropsychological Function in Children
*Toxins resulting in behavioral effects
Nutrition and Behavior: Complex Interdisciplinary Research
* overview of state of research in the 1980s.
* Excellent Feingold diet history, food dyes, hyperactivity, iron, vitamins, trace elements, violence
* Review of research on sublingual provocative testing & intracutaneous provocative testing
* The "I've tried everything" syndrome.
Altered Frontal and Temporal Brain Function during Olfactory Stimulation in Adult Attention-Deficit/Hyperactivity Disorder
*adhd, smell, olfactory, dopamine, adult, Schecklmann, Schenk, Maisch, Kreiker, Jacob, Warnke, Gerlach, Fallgatter, Romanos, Germany
Chlorinated hydrocarbons in human bone marrow of healthy individuals and leukemia patients
* Cancer, DNA, pilot study. Scheele, Teufel, Niessen
Reverberations of Militarism: Toxic Contamination, the Environment, and Health
* See also Schettler 2001 and 2006.
Toxic Threats to Neurologic Development of Children
The Precautionary Principle: Protecting Public Health and the Environment
Health and the environment: An ecological view of health
* Easy to read. Insights into medical training.
Sucralose, a synthetic organochlorine sweetener: Overview of biological issues
* Splenda, artificial sweetener, rats, cytochrome P-450, drug metabolism, chloropropanols, insulin, glucagon, glucose. Schiffman, Rother.schiff
ABSTRACTS OF THE XX INTERNATIONAL CONGRESS ON SCHIZOPHRENIA RESEARCH
- in its 421 pages, not one mention of gluten, casein, or food additives ... however, there is still a lot of interesting information. There are some sections discussing essential fatty acids and an apparent difficulty of their metabolism in these people, whose intake is okay but cell membranes showing a deficit (see page 239).
Comparative analysis of zinc status, food products' frequency intake and food habits of 11-year-old healthy children
Diurnal resting behavior of adult Culex pipiens in an arid habitat in Israel and
possible control measurements with toxic sugar baits
* food dye, mosquitoes, toxin
Does oligoantigenic diet influence hyperactive/conduct disordered children - a controlled trial
- Note: These were children with conduct disorder as well as ADHD. "dietary treatment cannot be neglected ..."
Correlation of applied kinesiology muscle testing findings with serum immunoglobulin levels for food allergies.
Is atopic disease a risk factor for attention-deficit/
hyperactivity disorder? A systematic review
- eczema independently related to ADHD
- asthma related but eczema goes along so they think it is the eczema that makes the relationship
Does anyone remember Hippocrates? - press release by Judy Schneider
Moderate Level Alcohol During Pregnancy, Prenatal Stress, or Both and
Limbic-Hypothalamic-Pituitary-Adrenocortical Axis Response to Stress in Rhesus Monkeys
*Monkeys, alcohol, FAS, hyperactivity, depression, fetal alcohol syndrome, autism, Asperger's, separation, Schneider, Moore, Kraemer.
Nutrition in the treatment of attention deficit hyperactivity disorder: a neglected but important aspect
The Los Angeles Probation Department Diet-Behavior Program: An Empirical Analysis of Six Institutional Settings.
Institutional Nutritional Policies and Criminal Behavior
The impact of a low food additive and sucrose diet on academic performance in 803 New York City public schools
The testing of various hypotheses as explanations for the gains in national standardized academic teset scores in the 1978-1983 New York City Nutrition Policy Modification Project
hypotheses for the rise in school scores
Controlled trial of vitamin-mineral supplementation: effects on intelligence
and performance
* Triple blind, placebo controlled. Nonverbal IQ highly significant gains in 100% supplement group.
* Schoenthaler, Amos, Eysenck, Peritz, Yudkin.
Applied Nutrition and Behavior
The effect of randomized vitamin-mineral supplementation on violent and non-violent antisocial behavior among incarcerated juveniles.
Vitamin-mineral intake and intelligence: A macrolevel analysis of randomized controlled trials
*IQ, intelligence, placebo control. Schoenthaler, Bier
The Effect of Vitamin-Mineral Supplementation on Juvenile Delinquency Among American Schoolchildren: A Randomized Double-Blind Placebo-Controlled Trial
The Effect of Vitamin-Mineral Supplementation on the Intelligence of American Schoolchildren: A Randomized Double-Blind Placebo-Controlled Trial
* Double blind study that "overcomes the primary criticisms directed at the previous 12 controlled trials."
* 81 matched pairs had no difference; 24 had very significant IQ gains of 15+ points; average gain of group 2.5 IQ points
* Schoenthaler, Bier, Young, Nichols, Jansenns.
Commentary on Gesch study
Executive Summary on Nutrition, Crime, and Delinquency
Toxic Tradeof: Exit Diazinon, Enter Carbaryl. Phaseout Leads to Risky Replacement
* Pesticides, fish, salmon, EPA. Schreder, Dickey.
Patent: Method and apparatus for measuring and treating hyperactivity in human beings
Can autism be triggered by acetaminophen activation of the endocannabinoid system?
* brain, MMR vaccine, asthma, glucuronidation, sulfation, cytochrome P-450.
Water Fluoridation and Crime in America
Cured meat products without direct addition of nitrate or nitrite:
what are the issues?
* Nitrites/nitrates, organic meat. Sebranek, Bacus.
Factors Which Influence Pigmentation
*Germany, eye, oxycarotenoid, egg yolk color, chicken color, storage, xanthophyll, alfalfa, lutein, synthetic apo-ester, marigold, canthaxanthin, citranaxanthin, antioxidants added to color, ethoxyquin, Loxidan, formaldehyde,sunlight
Lifelong consumption of sodium selenite: Gender differences on blood-brain barrier permeability in convulsive, hypoglycemic rats.
* in normal rats, induced seizures increase permeability of blood-brain barrier in both sides.
* Sodium selenite & hypoglycemia prevents permeability increase.
* Seker, Akgul, Oztas.
Attention-Deficit/Hyperactivity Disorder
- Note - p.274 - "Fad interventions for ADHD that have no scientific support include megavitamin therapy, chiropractic treatments,
ocular-motor training, and special diets."
Acute Generalized Exanthematous Pustulosis Due to Oral
Use of Blue Dyes
* food dye, color, blue dye, skin allergy, psoriasis
SENOMYX
Positive allosteric modulators of the human sweet
taste receptor enhance sweet taste
Molecular mechanism of the sweet taste enhancers
Predicting family poverty and other disadvantaged conditions for child rearing servin
from childhood aggression and social
withdrawal: A 30-year longitudinal study
Endogenous Methyl Salicylate in Pathogen-Inoculated Tobacco Plants
Different Effects of Inhaled Aspirinlike Drugs on Allergen-Induced Early and Late Asthmatic Responses
*Asthma, anti-inflammatory, indomethacin, salicylates, Sestini, Refini, Pieroni, Vaghi, Robuschi, Bianco.
The Restaurant Syndromes
* MSG, RAST, allergens, sulfites, scombroidosis, urticaria, bronchospasm, GI, hypotension, anaphylaxis
Methemoglobinemia in aluminum phosphide poisoning
- pesticide / hyperbaric oxygen considered / methylene blue didn't work
ADHD: Assessment and intervention
* a little bit of info about a lot of subjects. Shah, Cork, Chowdhury. UK
Acetylsalicylic Acid-Induced Hemolysis and Its Mechanism
* G6PD deficiency, aspirin sensitivity. Salicylate and its metabolite gentisate are important in rupture of red blood cells. Both inhibit G6PD enzyme.
Review: The potential role of natural agents in treatment of airway inflammation - asthma, COPD, fish oil, vitamin C etc.
Prevalence of Neurological Manifestations in a Human
Population Exposed to Fluoride in Drinking Water
Letters to the editor; Opioid peptides and dipeptidyl peptidase in autism, with reply by O'Hare
* comment on Hunter, O'Hare, Herron, Fisher, & Jones 2003shattock
A qualitative study of Australian GPs’ attitudes and practices in the diagnosis and management of attention-deficit/hyperactivity disorder (ADHD)
The effects of chronic administration of food colorings on activity levels and cognitive performance in normal and hyperactive developing rat pups
Effects of Chronic Administration of Food Colorings on Activity Levels and Cognitive Performance in Developing Rat Pups Treated With 6-Hydroxydopamine.
Aspartame, behavior, and cognitive function in children with attention deficit disorder
*adhd, Shaywitz, Sullivan, Anderson, Gillespie, Sullivan, Shaywitz
Note: results were averaged, so individual effects drowned out, but there was a significant difference in activity level.
Story and science: How providers and parents can utilize storytelling to combat anti-vaccine misinformation
* promotion of propaganda strategies to combat vaccine resistance.
Birch pollen and aspirin psoriasis: a study in salicylates hypersensitivity
System for the pH-dependent Release of a Dye in Model Dental Restorations.
- Note - It is not yet known whether this idea has ever been put into use, nor what kind of dye might be used.
Fructose Malabsorption and Symptoms of
Irritable Bowel Syndrome: Guidelines for Effective Dietary Management
Optimizing Epilepsy Management in Teenagers
Metabolic and mitotic changes associated with the fetal alcohol syndrome.
* FAS, retardation, alcohol, ethanol, DNA synthesis. Shibley, Pennington.
Differential colon DNA damage induced by azo food additives between rats and mice.
Severe Combined Immunodeficiency (SCID) and Attention Deficit
Hyperactivity Disorder (ADHD) Associated with a Coronin-1A
Mutation and a Chromosome 16p11.2 Deletion
Cognitive and Academic Consequences of Bronchopulmonary Dysplasia and Very Low Birth Weight: 8-Year-Old Outcomes
Lennox-Gastaut Syndrome - A Case Study of Monosodium Glutamate
*MSG, child, aspartame, seizures, Agent Smiley, Shovic, Bart, Stalcup
The American EPD Study: 1993-200
Risk of Intussusception Following Administration of a Pentavalent Rotavirus Vaccine in US Infants
* vaccine. children, babies infants. Shui, Baggs, Patel, Parashar, Rett, Belongia, Hambidge, Glanz, Klein, Weintraub.
Symposium: Pediatric Food Allergy
Food for Thought on Prevention and Treatment of Atopic Disease Through Diet
*Editorial, babies, atopy, asthma, breast-feeding, peanuts, pregnancy, eggs, milk, fish, hydrolysate, dermatitis, eczema.
Role of the brain-gut axis in alcohol-related gastrointestinal diseases - what can we learn from new animal models?
* alcohol, gi tranct, ethanol, addiction, rats. esophagus, diarrhea, neuropathy. Siegmund, Spanagel, Singer. Germany & US
Artificial Food Colors and Childhood Behavior Disorders
- 21 pages considering the early studies on children and animals, concluding that there is an effect, but that such children are "not numerous."
Diversificação alimentar no primeiro ano de vida/ Diversification in the first year of food life (Portuguese)
* antigen introduction at specific times (between 4 - 7 months) reduces allergic reactions later.
Hemoglobin and the Brain: A Piece of the Autism Puzzle?
* Autism, creating cerebral palsy in monkeys, the Bohr effect
Additive-Induced Urticaria: Experience with Monosodium Glutamate (MSG)
* Challenged subjects with urticaria, giving them MSG while they were ON antihistamine medication.
* Concluded MSG rarely makes urticaria worse.
* Study funded by International Glutamate Technical Committee.
Adverse Reactions to Food Additives
* Author maintains reactions to additives very rare, and research weak.
* Nice list of sulfite-containing foods, some sketchy info on each additive.
Medical Management of Attentional and Behavioral Difficulties of Childhood:
Stimulant and Non-stimulant Strategies
The Biochemistry of Attentional/Behavioral Problems - presented at the 1996 Feingold Association Conference in Orlando, FL
F.Y.I.: Natural treatments for kids with ADD/ADHD
- Although supportive of the use of diet, he is very careless about his facts. Here's what he says:
"The diet prohibits the intake of salicylates (found in artificial colors and flavors,
aspirin, grapes, tomatoes, red and green peppers) and replaces them with mineral soups, whole grains,
raw vegetables and fresh fruit."
A comparative study of fluoride ingestion levels, serum thyroid hormone & TSH level derangements, dental fluorosis status among school children from
endemic and non-endemic fluorosis areas
* drinking water, mechanism of replacing iodine in body: "The results of this study question the validity of the
fluoridation of drinking water, milk, fruit juices, and salt
by public health authorities ..."
* Singh, Verma, Sidhu, Sachdeva. India.
Nutritional and dietary influences on attention deficit hyperactivity disorder
Hazardous components of household waste.
* Review of components, environmental risk. Lack of information.
* Endocrine disrupters,heavy metals, paint, pesticides, pharmaceuticals, solvents.
* Slack, Gronow, Voulvoulis. UK.
Cognitive Tests: Interpretation for Neurotoxicity? - workshop summary
Observations on Infective Drug Resistance in Britain
*antibiotics, bacteria, Smith, Halls
Dental cements
Into the Mouths of Babes: Hyperactivity, Food Additives and the
History of the Feingold Diet.
Long-term persistence of IgE anti-influenza A HIN1 virus antibodies in serum of children
and adults following influenza A vaccination with subsequent H1N1 infection: a case study
* vaccine, H1N1, flu, IgE, allergy. Smith-Norowitz, Kusonruksa, Wong, Norowitz, Joks, Durkin, Bluth.
Herbal Product Contamination and Toxicity
Self-reported impulsivity in male offenders with low cognitive ability in New South Wales prisons
*prison, impulsive, violence, aggression, IQ, Snoyman, Aicken, Australia
The Society of Toxicologic Pathology and the ‘‘One Health’’ Initiative - combining human & veterinary health disciplines
Reviews And Critiques: 33 Clinical Trials Related to Artificial Food Colors and ADHD in Childhood and Related Problem Behaviors
* FDA, for 2011 Food Advisory Committee on food dyes
Overview and Evaluation of Proposed Association Between Artificial Food Colors and ADHD
* FDA, for 2011 Food Advisory Committee on food dyes
First Experimental Demonstration of the Multipotential Carcinogenic Effects
of Aspartame Administered in the Feed to Sprague-Dawley Rats
Life-Span Exposure to Low Doses of Aspartame Beginning during Prenatal Life Increases Cancer Effects in Rats
Carcinogenicity of Aspartame in Rats Not Proven
Consequences of Exposure to Carcinogens Beginning During Developmental Life.
Maternal Vitamin D Status in Gestational Diabetes Mellitus
Preventive interventions in families with parental depression:
children’s psychosocial symptoms and prosocial behaviour
The 'Twinkie Defense': the relationship between carbonated non-diet soft drinks and violence perpetration among Boston high school students
*weapon, violence, teens, Solnick, Hemenway
Treatment of Aspirin Exacerbated Respiratory Disease with a Low Salicylate Diet: A Pilot Crossover Study
* Salicylate, nasal polyps, asthma. Sommer, Hoffbauer, Au, Sowerby, Gupta, Nayan.
Nonpharmacological Interventions for ADHD: Systematic Review and Meta-Analyses of Randomized Controlled Trials of Dietary and Psychological Treatments
*" effects remained significant for ... artificial food color exclusion ..."
* Stevenson was the primary investigator of Bateman 2004 and McCann 2008 - but neither were included here.
* Sonuga-Barke, Brandeis, Cortese, Daley, Ferrin, Holtmann, Stevenson, Danckaerts, van der oord, Dopfner, Dittmann, Simonoff, Zuddas, Banaschewski, Buitelaar, Coghill.
Editorial: Diet and children’s behaviour problems – disentangling urban myth from clinical reality
* tries to find middle ground between proponents & opponents
Dietary exposure of children and teenagers to benzoates, sulphites, butylhydroxyanisol (BHA) and butylhydroxytoluen (BHT) in Beirut (Lebanon)
An unusual syncope cause in the ED: Favism
- G6PD deficiency (see other research on salicylate effects on G6PD; i.e., could taking aspirin have made the difference in this man since he had eaten fava beans previously without problem?
Aspartame: neuropsychologic and neurophysiologic evaluation of
acute and chronic effects
Notes:
Food Additives and Hyperkinesia : A Critical Evaluation of the Evidence
Case Studies of Effects of Artificial Food Colors on Hyperactivity
Note: used Nutrition Foundation cookies of 13 mg each, 1 in am and 1 in pm
The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders
Diet and hyperactivity: Is there a relationship?
*adhd, food dyes, food colors, diet, artificial flavors, hyperactivity, salicylates, negative review, Harvard, Stare, Whelan, Sheridan, Harvard
Letter to the editor of Pediatrics in answer to Campbell's complaint about his study
Managing attention deficit/hyperactivity disorder: unmet needs and future directions
Plasma glutamate concentrations in adult subjects ingesting monosodium L-glutamate in consomme.
Erythrocyte L-aspartyl-L-phenylalanine hydrolase activity and plasma phenylalanine and aspartate concentrations in children consuming diets high in aspartame
* Supported by grant from ILSI-Nutrition Foundation. See more information
* Stegink, Lindgren, Brummell, Stumbo, Wolraich.
Nitrogen metabolism in normal and hyperkinetic boys
In Harm’s Way: Toxic Threats to Child Development
* Developmental disabilities, genetic, toxic, toxins, social, brain
* Stein, Schettler, Wallinga, Valenti.
Artificial Food Coloring Promotes Hyperactivity
When Preschool Children Have ADHD
Environmental Threats to Healthy Aging: With a Closer Look at Alzheimer's & Parkinson's Diseases
* Neurodegenerative diseases, brain function; healthy at 100
* Greater Boston Physicians for Social Responsibility. Stein, Schettler, Rohrer, Valenti.
Essential fatty acid metabolism in boys with
attention-deficit hyperactivity disorder
Dietary Sensitivities and ADHD Symptoms: Thirty-five Years of Research
Mechanisms of behavioral, atopic, and other reactions to artificial food colors in children
* adhd, food dyes. corn syrup, intestinal permeability, sulfanilic acid, toxicity, liver stress, kidney, blood cells, blue 1 blocks P2X7 receptors, blood brain barrier, ADI, neurites, MAO, gut inflammation, degranulation of mast cells, aluminum, lakes, zinc, iron
Amounts of Artificial Food Colors in Commonly Consumed Beverages and Potential Behavioral Implications for Consumption in Children
* 77% of children drink 377 ml soda or fruit drinks ... if they drank Kool-Aid Burst Cherry, they got 81 mg Red 40 just from their drinks ... even in 1977 table, the MEAN of kids 6 - 12 years old got 181 mg/day food dyes.
* Stevens points out that the 26 mg food colors used in the early studies was too low both then and now.
Amounts of Artificial Food Dyes and Added Sugars in Foods and Sweets
Commonly Consumed by Children
* food dyes, sugar, Stevens, Burgess, Stochelski, Kuczek.
Rejoinder to Eigenmann PA, Haengelli CA, Food colourings and preservatives—allergy and
hyperactivity (Lancet 2004;364:823–4) and an erratum
Characterizing the ADHD phenotype for genetic studies
*adhd, genes, genetic, Stevenson, Asherson, Hay, Levy, Swanson, Thapar, Willcutt, Southampton U, UK
Food Additives and Children's Behaviour: Evidence-Based Policy at the Margins of Certainty
The Role of Histamine Degradation Gene
Polymorphisms in Moderating the Effects of Food
Additives on Children’s ADHD Symptoms
Food colors and behavior
* preview, not easy to read
Research Review: The role of diet in the treatment of attention-deficit/hyperactivity disorder - an appraisal of the evidence on efficacy and recommendations on the design of future studies.
* ADHD. UK. diet. food dyes. Stevenson, Buitelaar, Cortese, Ferrin, Konofal, Lecendreux, Simonoff, Wong, Sonuga-Barke.
Symrise develops toolbox to tackle stevia flavour issues
- Note - when they get done, can we still consider it a natural sweetener? Will our members tolerate it?
Metabolism of azo dyes by human skin microbiota
*Azo dyes, metabolization, anerobic bacteria, gut bacteria, carcinogenic metabolites. Stingley, Zou, Heinze, Chen, Cerniglia.
Nutritional Guidelines for Correcting Behavior
Risk of Fever After Pediatric Trivalent Inactivated Influenza Vaccine and 13-Valent Pneumococcal Conjugate Vaccine
* When given together, much higher rate of fever.
The effect of butylated hydroxyanisole and butylated hydroxytoluene on behavioral development of mice
Dark adaptation, motor skills, docosahexaenoic acid, and
dyslexia
Preschool Teachers’ Knowledge, Opinions, and Educational Experiences with Attention Deficit/Hyperactivity
Disorder
- Note - Again, they are concerned at the number of teachers who believe diet has something to do with ADHD.
- Note - Has it not occurred to any of these people that when a subject is CONTROVERSIAL it means, by definition, that there are two sides. Therefore, to include it in a true-false test where only one is correct ... well, that's just plain wrong.
Nutritional errors in the first months of life and their association with asthma and atopy in preschool children.
Candidemia Incidence in Recipients of Parenteral Nutrition - yeast
Immunization Safety Review: SV40 Contamination
of Polio Vaccine and Cancer
* Vaccines. Stratton, Almario, McCormick. 102 pages
Immunization Safety Review: Multiple Immunizations and Immune Dysfunction
* vaccines. Stratton, Wilson, McCormick. 152 pages
Experiences of Double-Blind, Placebo-Controlled Food Challenges (DBPCFC): a qualitative analysis of mothers’ experiences - allergy
Utilization of alternative therapies in attention-deficit hyperactivity disorder
*ADHD, CAM, Stubberfield, Wray, Parry, Australia
Contributions to variations in academic trajectories amongst recent immigrant youth
Estimated daily intakes of butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and tert-butyl hydroquinone (TBHQ) antioxidants in Korea
* Estimated levels were far below ADI
* Suh, CHung, Cho, Kim, Kim, Han, Kim. Korea.
Parentectomy in the crossfire
* Custody battles where parents make false accusations. Summers & Summers
Effects of High Fluoride Drinking Water on the Cerebral Function of Mice
Salicylate Increases the Gain of the Central Auditory System
*Tinnitus, hearing, deafness, rats, GABA, Sun, Lu, Stolzberg, Gray, Deng, Lobarinas, Salvi
Suclinical hyperthyroidism and hyperkinetic behavior in children
Effective interventional approach to control anaemia in pregnant women
An Australian Exclusion Diet
Salicylates in foods
- While she measured the quantity of salicylate in each food, she did not differentiate them by type of salicylate -- methyl, ethyl, octyl, acetyl, etc. A little of one type may be much more toxic than a lot of another type, but no study to define relative toxicities has yet been done.
The Role of Natural Salicylates in Food Intolerance (386 pages)
Study of intellectual performance of children in ordinary schools after certain serious complications of whooping cough
* Children who had seizures or apnea with wooping cough had lower IQ and poorer school performance. About 11% of the group with whooping cough with seizures had been vaccinated. 13% of the group who had whooping cough without complications, and 41% of the group who did not get sick were vaccinated.
Food dyes impair performance of hyperactive children on a laboratory learning test
Letter re: Food dyes and impairment of performance in hyperactive children
* complains of criteria for diagnosing hyperactivity, between-group focus<, says Feingold diet not assessed for response
* Ferguson, Rapoport, Weingartner, NIH
fergu
Response to Ferguson's complaint about 1980 study (above)
Letters complaining about Swanson's lack of mention of diet treatment in a seminar, and his response to them.
Evidence for Direct-acting Oxidative Genotoxicity by Reduction Products of Azo Dyes
*food dyes, DNA damage, Sweeney, Chipman, Forsythe, UK
*QUOTE final sentence: "The identification of this type of DNA damage hitherto not detected by many conventional genotoxicity assays may have important implications regarding the continued use of azo dyes in foodstuffs."
The history of pellagra, its recognition as a disorder of nutrition qand its conqest.
Pharmacokinetic Consequences of Active Drug Efflux at the Blood–Brain Barrier
* opioids, morphine. Syvanen, Xie, Sahin, Hammarlund-Udenaes. Turkey
Low-calorie bread baked with charred cellulose granules and wheat flour to eliminate toxic xanthene food dye in the alimentary canal.
* Good overview of toxic properties of xanthene food dyes including Red 3. The charcoal granules adsorb the food dye and remove it from the GI tract. Tabara, Yamane, Seguchi. Japan.
Antioxidants reversibly inhibit the spontaneous resumption of meiosis
*BHA, antioxidants, oocyte maturation, meiosis, Takami, Preston, Toyloy, Behrman
A Clinical Study of ADHD Symptoms With Relation to Symptoms of Learning Disorders in Schoolchildren talerin Bogota, Colombia
Attention Training for School-Aged Children With ADHD: Results of an Open Trial
Tourette's Syndrome Manifests as a Chronic Persistent Cough
*TS, asthma, case report, twins, tic disorder, misdiagnosis, Tan, Buyukavci, Arik. Turkey.
Reproductive and neurobehavioural toxicity study of tartrazine administered to mice in the diet
- Note: the weirdest thing about this is that after finding the clear effects, they decided that people would be okay because their dietary intake is PRESUMED to be much lower.
Effects of tartrazine on exploratory behavior in a three-generation
toxicity study in mice
Fluoride and Children's Intelligence: A Meta-analysis
It’s time to re-think mental health services for children in care, and those adopted from care
- see also DeJong 2010
Food-Based Strategies for Depression Management From Iranian Traditional Medicine Resources
* Comparing modern diet recommendations and findings with Iranian Traditional Medicine manuscripts
Adverse effects of monosodium glutamate on liver and kidney functions in adult rats and potential protective effect of vitamins C and E
* MSG, rats, urea, creatinine, oxidative stress. Tawfik, Al-Badr. Egypt, Saudi Arabia.
Perinatal Exposure to Chemical Agents: Delayed Effects by
the Mechanism of Imprinting (Cell Programming)
*Hormones, pollutants, metals, pesticides, drugs, smoking
Evaluation of vitamin A supplementation regimens in Ghanaian
postpartum mothers with the use of the modified-relative-doseresponse
test
* Tchum, Tanumihardjo, Newton, Benoist, Owusu-Agyei, Arthur, Tetteh.
* vitamin deficiency, children.
Stroke: Epidemiology, Clinical Picture, and Risk Factors - Part I of III
Effects of (.)-4-{[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio}phenol Hydrochloride (SIB-1553A), a Selective Ligand for Nicotinic
Acetylcholine Receptors, in Tests of Visual Attention and Distractibility in Rats and Monkeys
- Translation: trying to see if a chemical related to nicotine could help ADHD
Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent
* liver disease, sedentary behavior, western diet, liver disease, fatty liver disease, steatosis, insulin resistance, obesity,
* glucose intolerance, steatosis. Tetri, Basaranoglu, Brunt, Yerian, Neuschwander-Tetri. See also Basaranoglu 2013
Practitioner Review: What have we learnt about the causes of ADHD?
* genetic risks small; Thapar, Cooper, Eyre, Langley. UK.
The Peroxidase-dependent Activation of Butylated Hydroxyanisole and Butylated Hydroxytoluene (BHT) to Reactive Intermediates: Formation of BHT-Quinone Methide via a Chemical-CHemical Interaction
*BHA, BHT, interaction, toxic metabolites, Thompson, Cha, TRush
Picky Eating Habits or Sensory Processing Issues? Exploring Feeding Difficulties in Infants and Toddlers
Children's Self-Reports on Perceived Effects on Taking Stimulant Medication for ADHD
Pilot study to assess behavioural and cognitive effects of artificial food colours in a group of retarded children
* food dyes, additives,
* Notes:
(1) Only 10 children (and only 7 were considered hyper)
(2) Children were on diet only 14 days before challenge;
(3) No indication of improvement reported before challenges begun
(4) used 98 mg color ... but included B carotene, titanium dioxide, carmoising, annatto, iron oxides
(5) Reported group (averages of all) scores
Predicting intention to attend and actual attendance at a universal parent-training programme: A comparison of
social cognition models
- amusing; people who attended first intended to attend .... 20 pages of that? did not print it
The biocontaminants and complexity of damp indoor spaces: more than what meets the eyes
Patent application: Manufacturing process of spheroidal food dyes
Effect of globalisation on children’s mental health
"Western child psychiatrists have much to learn from child rearing
practices in other countries."
Vaccination may be associated with autoimmune diseases.
Herbivore-Induced SABATH Methyltransferases of
Maize That Methylate Anthranilic Acid Using
S-Adenosyl-L-Methionine
Diet and mental health in children
* food additives, dyes, fish oil. Tomlinson, Wilkinson. UK.
The NAC Pilot Project: A Model for Nutrition Screening and Intervention for Developmentally Disabled Children with Behavior Disorders
* sensitivities by cytotoxic testing: Red 3, Red 4, Red 40; Yellow 5, Yehhow 6; chocolate, milk, egg,
corn, Red 40, soybean, peanut
* Torisky, Torisky, Kaplan, Speicher.
Is fever suppression involved in the etiology of autism and neurodevelopmental disorders?
* immune system, nervous system, brain, pregnancytorres
Role of acetyl salicylic acid and sodium metabisulfite in chronic childhood asthma
*asthma, sulfite, aspirin, salicylates, diet. Towns, Mellis
Toxicology, July 1996, Vol. 111 No. 8, 1-345
Final Report on the Safety Assessment of Aloe Andongensis Extract, Aloe Andongensis Leaf Juice, Aloe ...
Final Report on the Safety Assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate
Final Report on the Safety Assessment of BHT
Annual Review of Cosmetic Ingredient Safety
Assessments—2004/20051
Amended Final Report on the Safety Assessment
of Ethyl Methacrylate - used in artificial fingernail products
US FDA "Redbook II" Immunotoxicity Testing Guidelines and Research in Immunotoxicity Evaluations of Food Chemicals and New Food Proteins
ILSI Alternatives Methods for Carcinogenicity Testing Workshop Poster Abstracts
Safety Assessment of Salicylic Acid, Butyloctyl Salicylate, Calcium Salicylate, C12–15 Alkyl Salicylate, Capryloyl Salicylic Acid, Hexyldodecyl Salicylate,
Isocetyl Salicylate, Isodecyl Salicylate, Magnesium Salicylate, MEA-Salicylate, Ethylhexyl Salicylate, Potassium Salicylate, Methyl Salicylate, Myristyl
Salicylate, Sodium Salicylate, TEA-Salicylate, and Tridecyl Salicylate1
Modelo dietético en pacientes con déficit de atención ehiperactividad
* Spane. In Spanish. ADHD Nutrition
Intake Pattern Of Synthetic Colours by Different Age and Socio-Economic Consumer Groups of Lucknow, India
Diet treatment for hyperactive childen with food allergies
* source of "small subgroup" quote, maybe? He was not testing the Feingold diet but an allergy diet based on RAST tests on each child; additives apparently were not eliminated. He used diet for only 3 weeks on kids newly off meds. It's amazing SOME of them improved. For kids without allergy, some improved on the placebo diet - not surprising; the placebo diet also randomly eliminated stuff, so that families used fewer processed foods but had to cook from scratch, automatically eliminating many additives.
The Great Lead Water Pipe Disaster
Effectiveness of meningococcal serogroup C conjugate vaccine 4 years after introduction
* Short term effectiveness. Herd immunity.
* Long-term effectiveness unknown; immunity of infants declines after 1 year.
* Trotter, Andrewes, Kaczmarski, Miller, Ramsay. UK
Asperger Syndrome and Medication Treatment
Lead levels in Canadian children: Do we have to review the standard?
* Levels once considered safe can adversely affect the neurodevelopment of children. Tsekrekos, Buka.
Updates on the Genetics of Neurodegenerative Disorders
Changes in Fluoride Levels in the Liver, Kidney, and Brain and in Neurotransmitters of Mice After Subacute Administration of Fluoride
The Adverse Effects of Food Additives on Health: A Review of the Literature with Special
Emphasis on Childhood Hyperactivity
A Toxic Legacy: The U.S. Military in the Philippines and Puerto Rico
* Turalba, Willmott.
Turkish Special Education Teachers’ Reported Use of Positive and Reductive Interventions for Problem Behaviors: An Examination of the Variables Associated With Use
Melatonin supplementation for severe and intractable sleep disturbance in young people with genetically determined developmental disabilities: short review and commentary
What is the evidence for our standards of care? (editorial)
Hair Lead Levels Related to Children's Classroom
Attention-Deficit Beihavior
- last page (of references) missing, and quality poor. If difficult to read, I have another one scanned at 600dpi, which includes the missing last page. It may be better quality, but give it time to load. See it here.
Developmental Toxicity Evaluation of Sodium Thioglycolate Administered Topically to Sprague-Dawley (CD) Rats and New Zealand White Rabbits
*Rats, Rabbits, sodium thioglycolate, cosmetics, hair care, developmental toxicity, Tyl, Price, Marr, Myers, Birgelen, Jahnke.
Linking Home-School Dissonance to School-Based Outcomes for African American High School Students
The Effects of a Vitamin D-deficient Diet on Chronic Cadmium Exposure in Rats
Brain lesions and eating disorders
Potential viral pathogenic mechanism for new variant inflammatory bowel disease
* Autism, GI, measles, vaccine.
* Uhlmann, Martin, Sheils, Pilkington, Silva, Killalea, Murch, Walker-Smith, Thomson, Wakefield, O'Leary.
Topographic mapping of brain electrical activity in children with food-induced attention deficit hyperkinetic disorder
Prevalence of bullying and aggressive behavior and their relationship to mental health problems among
12- to 15-year-old Norwegian adolescents
Platelet Serotonin Measures in Adolescents Conduct Disorder
* Serotonin dysregulation, aggression.
* There are numerous other studies showing a dietary connection to serotonin function - this is not hardwired.
See BACKON 1989, BHAGAVAN 1977, DALAL 2010 to start.
* Unis, Cook, Vincent, Gjerde, Perry, Mason, Mitchell.
Experimental impact of aspirin exposure on rat intestinal bacteria, epithelial cells and cell line
The effects of provocation by foods with raised IgG antibodies and additives on the course of
Crohn’s disease: A pilot study
* diet, GI. Uzunismail, Cengiz, Uzun, Ozbakir, Goksel, Demirdag, Can, Balci. Turkey.
END VACCINE INFORMATION
The relationship between depression and serum ferritin level
Efectos del flúor sobre el sistema nervioso central
Effects of the fluoride on the central nervous system (TRANSLATED)
Asthma induced by alcoholic drinks: A new food allergy questionnaire
*asthma, wine, Vally, de Klerk, Thompson, Australia
Alcoholic drinks: Important triggers for asthma
*asthma, allergy, sulfites, salicylates, Vally, de Klerk, Thompson, Australia
Role of sulfite additives in wine induced asthma: single dose and cumulative dose
studies.
The prevalence of aspirin intolerant asthma (AIA) in Australian asthmatic patients.
Alcoholic drinks and asthma
*asthma, sulfites, salicylates. Vally, Thompson
Clinical effects of sulphite additives
* allergy, sulfites, preservative, dermatitis, urticaria, hypotension, abdominal pain, diarrhea, asthma, anaphylaxis
* Vally, Misso, Maden. UK.
Adverse reactions to the sulphite additives
* Sulfites, preservative, antioxidant, dermatitis, urticaria, abdominal pain, gi, diarrhea, asthma
Food and food additives in severe atopic dermatitis
*allergy, tartrazine, benzoate, MSG, sulfite, salicylate, tyramine, Van Bever, Docx, Stevens
Food intolerance in rheumatoid arthritis. II.
Clinical and histological aspects
* Diet-responsive patients had increased mast cells; underlying immunoallergological mechanism.
* van de Laar, Aalbers, Bruins, van Dinther-Janssen, van der Korst, Meijer.
The co-occurrence of autism spectrum disorder and attention-deficit/hyperactivity disorder symptoms in parents of children with ASD or
ASD with ADHD
*adhd, autism, genetic, Netherlands, parents
Effects of fish oil supplementation in rheumatoid arthritis
* Effective. 12 capsules fractionated (?) fish oil. van der Tempel, Tulleken, Limburg, Muskiet, van Rijswijk.
Aspirin-exacerbated asthma
* aspirin inhibits enzyme cycooxygenase-1 (COX-1). Varghese & Lockey
Chronic administration of aluminum-fluoride or sodium-fluoride to rats in drinking water: alterations in neuronal and cerebrovascular integrity.
Foster Mother Care but not Prenatal Morphine Exposure Enhances Cocaine Self-Administration in Young Adult
Male And Female Rats
* Sensitization, drug use. Vathy, Slamberova, Liu. Czech Republic & NY.
Food allergies and hypersensitivities
* Continuing Education Program, American Academy of Otolaryngology. 49 pages
* pg. 21, Nonimmunologic reactions: "Toxic reactions result from food components or additives, such as monosodium glutamate, food dyes, bisulfites, ..."
* Veling & Trevino.
Factors Associated With Maternal Dietary Intake, Feeding and Weaning Practices, and the Development of Food Hypersensitivity in the
Infant
*Babies, breastfeeding, weaning age, survey, atopy, allergy, Venter, Pereira, Voigt, Grundy, Clayton, Higgins, Arshad, Dean, UK.
Undiagnosed silent coeliac disease: a risk for
underachievement?
This article discusses silent coeliac with behavioral disorders. It may explain why some children with ADHD need to remove gluten - beyond the simple Feingold diet - before seeing much improvement. Our materials provide an introduction to the gluten-free/casein-free diet.
Nutrition, immunological mechanisms and dietary immunomodulation in ADHD
* gut, gi, immune, cytokines, ear infections, eczema, asthma, food additives, epigenetic changes to gene expression,
* oxidative stress, T-cell, neuroinflammation, prenatal stress, diet, supplements, allergy, EPD
* Discusses immune dysregulation but does not mention vaccination's role in that.
Safety and Efficacy of a Pentavalent Human–Bovine (WC3) Reassortant Rotavirus Vaccine
* Intussesception risk similar to placebo - no comparison to non-vaccinated babies
* Vesikari, Matson, Dennehy, Van Damme, Santosham, Rodriguez, Dallas, Heyse, Goveia, Black, Shinefield, Christie, Ylitalo,
* Itzler, Coia, Onorato, Adeyi, Marshall, Gothefors, Campens, Karvonen, Watt, O'Brien, DiNubile, Clark, Boslego,
* Offit, Heaton (at Merck).
ABC of complementary medicine: Unconventional approaches to nutritional medicine
Prevalence of Plastic Additives in Indoor Air related to Newly Diagnosed Asthma
Food-specific IgG Antibody–guided Elimination Diets Followed by Resolution of Asthma Symptoms and Reduction in Pharmacological Interventions in Two Patients: A Case Report
* Eliminatng whole foods, no mention of additives. However, this kind of diet automatically eliminates most processed foods too. Accidental Feingold diet?
Can one hour per week of therapy lead to lasting changes in young children with autism?
* Parents learn ABA, Early Start Denver Model. Vismara, Colombi, Rogers.
*Claim maybe the kids used other drugs, maybe the ADHD itself caused the deaths, etc.
Attention-Deficit Hyperactivity Disorder (ADHD)
Immune Reactivity to Food Coloring
* Food dyes can bond to food or proteins, acting in stealth mode to disrupt immune system.
Methylphenidate Decreased the Amount of Glucose Needed by the Brain to Perform a Cognitive Task
* Ritalin, ADHD, stimulants, amphetamine, PET, glucose, brain. Volkow, Fowler, Wang, Teland, Logan, Wong, Ma, Pradhan, Benveniste, Swanson.
Farm living: effects on childhood asthma and allergy
*raw milk, Mutius, Vercelli, see also Loss 2011
Allergy, Toxins, and the Learning Disabled Child
Developmental Toxicity and Psychotoxicity of FD
and C Red Dye No. 40 (Allura Red AC) in Rats
Prenatal Immune Activation Interacts with Genetic Nurr1 Deficiency in the Development of Attentional Impairments
*Sweden, cancer, mouse, dopamine, brain disorders, prenatal infection, Vuillermot, Joodmardi, Perlmann, Ogren, Feldon, Meyer
Food Additives and Cancer: Banging the Drum - Letter to the Editor, Toxicologic Pathology
Immunohistochemical study of tissue factor expression in normal intestine and idiopathic inflammatory bowel disease.
Early mucosal changes in Crohn's disease
Factor XIIIA subunit and Crohn's disease
Immunohistochemical study of vascular injury in
acute multiple sclerosis
Measles virus induction of human endothelial cell tissue factor procoagulant activity in vitro
Document takes a long time to load
Persistent measles virus infection of the intestine: confirmation by immunogold electron microscopy
Genetics versus environment in inflammatory bowel disease: results of a British twin study
Gastric mucosal contraction and vascular injury induced by indomethacin precede neutrophil infiltration in the rat
Thrombotic vascular risk factors in inflammatory bowel disease
Antineutrophil cytoplasm autoantibodies against bactericidal/permeability-increasing protein in inflammatory bowel disease
Detection and comparative analysis of persistent measles virus infection in Crohn's disease by immunogold electron microscopy
Vascular anatomy defines sites of indomethacin induced jejunal ulceration along the mesenteric margin
Ulceration of the ileum in Crohn's disease: correlation with vascular anatomy
Focal reduction of villous blood flow in early indomethacin enteropathy: a dynamic vascular study in the rat
Characterization of the Humoral Immune Response to Klebsiella Species in Inflammatory Bowel Disease and Ankylosing Spondylitis
Absence of Escherichia coli, Listeria monocytogenes, and Klebsiella pneumoniae antigens within inflammatory bowel disease tissues
Prevalence of inflammatory bowel disease in British 26 year olds: national longitudinal birth cohort
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and
pervasive developmental disorder in children - This is the article later retracted by Lancet. Read it yourself.
Inflammatory bowel disease and laterality: is left handedness a risk?
Potential viral pathogenic mechanism for new variant inflammatory bowel disease
Enterocolitis, autism and measles virus
Autism, Ileal-Lymphoid-Nodular Hyperplasia and Measles
Prevalence of gastrointestinal diseases in two British national birth cohorts
Wakefield sues BMJ over MMR articles
Test and Product Review: Freer, P. (2003). Play Attention Interactive Learning Tool. Asheville, NC:
Unique Logic and Technology Inc. - J. of Attention Disorders
Neurodevelopment and Schizophrenia : Broadening the Focus
Reduced violent behavior following biochemical therapy
(Pfeiffer Treatment Center)
Adverse Reactions to Aspartame: Double-Blind Challenge in Patients from a Vulnerable Population
* mood disorders: unipolar depression
* IRB stopped study after 13 subjects because of severe reactions
* People with depression are very vulnerable to reaction to aspartame
* Walton, Hudak, Green-Waite
Parental criticism and treatment outcome in adolescents hospitalized for severe, chronic asthma
* Parents of children with & without (control group) asthma were observed.
* Parents of children with asthma were more negative and critical; children were noncompliant and oppositional.
* BUT those children with more critical parents responded better to treatment when separated from parents and forced to follow structured treatment.
* Improvement is only short-term, until back in family. Called them "family-reactive rapid remitter" asthmatic children
* Wamboldt, Wamboldt, Gavin, Roesler, Brugman.
Changes of the Human Erythrocyte Membrane Protein SH Binding Site Property With Exposure uo Fluoride
and Three Strong Mutagens.
Comparison of three inhaled non-steroidal anti-inflammatory drugs on the airway response to
sodium metabisulphite and adenosine 5'-monophosphate challenge in asthma
*Asthma, bronchoconstriction, inhaled NSAID, Wang, Wisniewski, Pavord, Knox, Tattersfield
Arsenic and fluoride exposure in drinking water: Children's IQ and growth in Shanyin County, Shanxi Province, China
* also controls were taller, heavier, and had better lung capacity. Wang, Cheng, Li, Sang, Zhang, Han, Qiao, Wu. China.
Dietary Intake Patterns of Low-Income Urban African-American Adolescents
* Several unhealthy eating patterns such as sweetened beverages, fried foods, and high-fat snacks prevailed in their diets
* Not mentioned but obvious is that these children are also exposed to high levels of additives
* Wang, Jahns, Tussing-Humphreys, Xie, Rockett, Liang, Johnson.
Early Infantile Autism: Diagnosis, Etiology, and Treatment
*autism, very old article gives historical view of early attitude toward autism, refers to "refrigerator mothers"
The influence of the chemical additive tartrazine on the zinc status of hyperactive children: A double-blind placebo-controlled study
Assessment of chemical factors in relation to child hyperactivity
Rotavirus Immunoglobulin A Responses Stimulated by Each of 3 Doses of a Quadrivalent Human/
Bovine Reassortant Rotavirus Vaccine
* Ward, Bernstein, Smith, Sander, Shaw, Eiden, Heaton, Offit, Clarkward
Sulphur Metabolism in Autism
* Autistic children excreted more sulfate, sulfite, and thiosulfate, but less thiocyanate.
* See diet suggestions, page 30.
* Waring, Klovrza, UK.
Phytoestrogens and Xenoestrogens: The Contribution of Diet
and Environment to Endocrine Disruption
*Phthalates, Phenols, Sulfotransferase, PST, Phenolic, Soy, Cancer, Waring, Ayers, Gescher c, Glatt, Meinl, Jarratt, Kirk, Pettitt, Reab, Harris
Cell-mediated immune responses to artificial food additives in chronic urticaria
Identification of Attentional and Hyperactivity Problems in Primary Care: A Report from Pediatric Research in Office Settings and the Ambulatory Sentinel Practice Network.
European Food Safety Authority
European agency rejects links between hyperactivity and food additives
Incidence of Bronchoconstriction Due to
Aspirin, Azo Dyes, Non-Azo Dyes, and
Preservatives in a Population of Perennial
Asthmatics
*Asthma, Salicylate, Yellow 5, Yellow 6, Tartrazine, Sunset Yellow, Amaranth, Ponceau, Erythrosine, Brilliant Blue, Blue 1, Indogotin Blue 2, Sodium Benzoate, BHA, BHT, Nasal Polyps, Weber, Hoffman, Raine, Nelson
* Used small doses of food dyes & used bronchodilator meds the entire time of the study!
E
limination diets in the management of eosinophilic esophagitis
* artificial colors, flavors, corn syrup, salicylates, all allowed on this diet. In fact, candies and drinks allowed to contain ONLY sugar and artificial flavors/colors.
Oxidative stress induced by urban fine particles in cultured EA.hy926 cells
Behavioral responses to artificial food colors
(Dr. Weiss is a toxicologist at U of Rochester School of Medicine)
Food additives and environmental chemicals as sources of childhood behavioral disorders
Food Additive Safety Evaluation: The link to behavioral disorders in children
Food Additives as a Source of Behavioral Disturbances in Children
Low level chemical sensitivity: a perspective from behavioral toxicology
Food Additives and Hyperactivity
This letter appears at the bottom on Page 3 of this article.
Synthetic Food Colors and Neurobehavioral Hazards: The View from Environmental Health Research
Low-Level Lead Exposure and Elevations in Blood Pressure during Pregnancy
The Food Additive-Free Diet in the Treatment of Behavior Disorders: A Review
Nutritional Influences on Aggressive Behavior
* conduct disorder, adhd, oppositional defiant disorder, aggressive behavioral syndrome organic personality syndrome.
* vitamins: niacin, pantothenic acid, thiamine, vitamin B6, vitamin C
* minerals: iron, lithium, magnesium, manganese, heavy metals, aluminum, cadmium, lead
* amino acids:serotonin, tryptophan, reactive hypoglycemia, food sensitivity
The Toxic Effects of Cigarette Additives. Philip Morris’ Project Mix Reconsidered: An Analysis of Documents Released through Litigation
*Tobacco, cigarettes, FDA
Symptoms of psychological distress and suicidal ideation among banana workers with a history of poisoning by organiphosphate or n-methyl carbamate pesticides.
- Note - you hear a lot about the farmers in India who buy the Monsanto GMO seeds and end up killing themselves. I wonder how much of that is financial stress and how much is pesticide poisoning?
A Comparison of Teachers' and Parents' Knowledge and Beliefs About Attention-Deficit/Hyperactivity Disorder(ADHD)
- Note: They complained that "66 percent of teachers mistakenly reported ADHD could be
caused by dietary intake of sugar or additives." The author said, "Of particular
concern is that 34 percent of teachers incorrectly identified special
diets as an effective form of treatment for ADHD." Bekle 2004, found that 78% of teachers thought it was an effective treatment. Can't they get it that a teacher will certainly recognize an effective treatment when she/he sees one? Teachers are down there in the trenches with the kids, after all.
Food Insecurity and the Risks of Depression and
Anxiety in Mothers and Behavior Problems in their Preschool-Aged Children
Serial Pediatric Symptom Checklist Screening in Children with Prenatal Drug Exposure
Correlation of urinary excretion of cysteine - sulphate metabolites and trans-indolyl-3-acrloylglycine (IAcrGly) in ten children diagnosed with pervasive developmental disorders.
* Durham Conference Proceedings. UK.
* Possible link between immune system and tryptophan and cystein pathways in PDD, autism.
* Problem in cysteine - sulphate metabolism. Sulfate. See Waring 2000.
* Whiteley, Waring, Shattock, Hooper.
The ScanBrit randomised, controlled, single-blind study of a gluten- and casein-free
dietary intervention for children with autism spectrum disorders
* Whiteley, Haracopos, Knivsberg, Reichelt, Parlar, Jacobsen, Seim, Pedersen, Schondel, Shattock. Denmark/Norway.
*Note: Group A (diet) did so well that Group B was given the diet too after 12 months.
Gluten- and casein-free dietary intervention for autism spectrum conditions.
* Review. Whiteley, Shattock, Knivsberg, Seim, Reichelt, Todd, Carr, Hooper. UK, Norway.
Spatial Alternation Deficits Following Developmental Exposure to Aroclor 1254 and/or Methylmercury in Rats
The Effect of Acid/Alkaline Nutrition on Psychophysiological Function
Maternal food consumption during pregnancy and asthma,
respiratory and atopic symptoms in 5-year-old children
* allergy, apples, fish protective effect. Willers, Devereux, Craig, McNeill, Wijga, El-Magd, Turner, Helms, Seaton. Netherlands.
Relative effects of drugs and diet on hyperactive behaviors: an experimental study
Aspirin-like effects of selected food additives and industrial sensitizing agents.
- Testing in pairs -- These results also support the hypothesis that single "challenges" of food coloring alone are not sufficient when testing the relationship of diet and behavior.
Review of antiviral and immunomodulating properties of plants of the Peruvian rainforest with a particular emphasis on Una de Gato and Sangre de Grado.
Parent-Reported Attention-Deficit Hyperactivity Disorder Symptomatology and Sleep Problems in a Preschool-Aged Pediatric Clinic Sample
A double-blind assessment of additive intolerance in children using a 12 day challenge period at home
* adhd, asthma, urticaria. Yellow 5/6, sulfite/benzoate.
* Challenge was only 8.5 mg each Yellow 5 & 6 per day, or 8.5 sulfite + 55 mg benzoate
* Note: challenges were added to a British drink called Lucozade, which was also the control drink.
* Ingredients of Lucozade vary but seem to include various artificial flavorings, the preservatives potassium sorbate
& sodium bisulfite, caffeine, and a lot of sugar. Some flavors contain artificial coloring too.
* Besides the additives in the "control" drink, caffeine is a stimulant similar to Ritalin.
Characteristics of Pediatric and Adolescent Patients Attending a Naturopathic College Clinic in Canada
Autism Spectrum Disorders in Relation to Distribution of Hazardous Air
Pollutants in the San Francisco Bay Area
Chiropractic management of a 6-year-old-child wth ADHD
* Child got better in 6 weeks of care including chiropractic adjustments and nutritional supplementation. Child began cod liver oil, DMG, folic acid, B12, plus liquid vitamin designed for ADHD. Plus dietary changes to decrease amount of food dyes and additives.
* Wittman, Vallone, Williams.
Antivaccinationists past and present
Note that in all the studies on sugar, all used TABLE SUGAR, not CORN
SYRUP which is what the cildren are actually ingesting.
Effects of Diets High in Sucrose or Aspartame on The Behavior and Cognitive
Performance of Children
The Practical Aspects of Diagnosing and Managing Children with Attention Deficit
Hyperactivity Disorder
* diet is discussed under "unorthodox treatments" and discounted. Rowe & Rowe 1994 & Boris 1994 totally ignored.
* Wolraich, Baumgaertel
Xanthene Food Dye, as a Modulator of Alzheimer’s Disease Amyloid-beta Peptide Aggregation and the
Associated Impaired Neuronal Cell Function
*Dementia, memory, behavior, thinking, cognitive function, Red 3, Erythrosin,
blood brain barrier, Red 3 to treat or prevent Alzheimer's? Wong, Kwon
Dietary Patterns in Children with Attention Deficit/Hyperactivity Disorder (ADHD)
* In Korea, the "traditional-healthy" diet was associated with lower odds of having ADHD, and the "snack pattern" was positively associated with the risk of ADHD.
The potential impact of the use of homeopathic and herbal remedies on monitoring the safety of prescription products
A Child with Chronic Manganese Exposure from Drinking Water
* Case report of child with elevated manganese from well water. Poor memory, attention deficits. Brother's level was normal but hair elevated, so apparently brother was better at detox. Woolf, Wright, Amarasiriwardena, Bellinger
Non-Nutritional Uses of Nutrients
Antagonistic control of a dual-input mammalian gene
switch by food additives
* benzoates, Flavoring, preservatives. Xie, Ye, Charpin-El Hamri, Fussenegger. Switzerland.
XIVIATM White Paper: Sustainable and substantiated - Making Xylitol from wood @ the paper mill
Sunset yellow FCF, a permitted food dye, alters functional responses of
splenocytes at non-cytotoxic dose
* Yellow 6, immune system, changes gene expression. Yadav, Kumar, Tripathi, Das. India.
Vitamin B12 and folate concentrations during pregnancy
and insulin resistance in the offspring: the Pune Maternal
Nutrition Study
* Diabetes, Yajnik, Deshpande, Jackson, Refsum, Rao, Fisher, Bhat, Naik, Coyaji, Joglekar, Joshi, Lubree, Deshpande, Rege, Fall.
Antioxidant intervention of smoking-induced lung tumor in mice by
vitamin E and quercetin
A Critical Role for Protein Tyrosine Phosphatase Nonreceptor Type 5 in Determining Individual Susceptibility to Develop Stress-Related Cognitive and Morphological Changes
* calcium channel blockers. Yang, Huang, Hsu. Taiwan
Gain weight by “going diet?” Artificial sweeteners and the neurobiology of sugar cravings
* history, neurobiology of food reward, obesity. research shows weight gain from artificial sweeteners.
Estimation of autistic children by metallomics analysis
* autism. aluminum, lead, cadmium, mercury, arsenic. epigenetic. Yasuda, Tsutsui.
* toxic metals, low zinc. calcium, magnesium deficiency. Japan
Parabens as Urinary Biomarkers of Exposure in Humans
* Paraben in urine is in conjugated forms. Have estrogenic activity.
* Ye, Bishop, Reidy, Needham, Calafat.
Assessment of the Determination of Azodicarbonamide and Its Decomposition Product Semicarbazide: Investigation of Variation in Flour and Flour Products
* bread bleaching additive, semicarbazide, cancer, tumors, flour
* Ye, Wang, Sang, Liu. China
Induction of Phenolsulfotransferase Expression by Phenolic
Acids in Human Hepatoma HepG2 Cells
Modulation of Hepatic Phase II Phenol Sulfotransferase and Antioxidant Status by Phenolic Acids in Rats
EFSA: Scientific Opinion on the re-evaluation Tartrazine (E 102)
Revised exposure assessment for Sunset Yellow FCF based on the proposed
revised maximum permitted levels of use as a food additive
Food safety involving ingestion of foods and beverages prepared with phthalate-plasticizer-containing clouding agents
*Taiwan, phthalate, sperm DNA damaage, eczema, asthma, rhinitis, hormones, endocrine disruptor, ADHD, low IQ, thyroid hormone change, Yen, Tan, Lin
Happy gut, happy mouse?
* editorial; gut microbe balance, dysbiosis, autism
Insulin Increases Retinal Hemorrhage in Mild Oxygen-Induced Retinopathy in the Rat: Inhibition by Riluzole
* diabetes, macular degeneration
Assessment of estimated daily intakes of benzoates for average and high consumers in Korea
* Levels were considered safe. Foods contributing most to benzoate intake were beverages and soy sauce.
* Yoon, Cho, Park, Lee, Park, Cho, Han, Lee, Lee
Amalgam allergy associated with exacerbation of aspirin-intolerant asthma
The Influence of Sucralose on Bacterial Metabolism
Clinical nutrition: 3. The fuzzy
boundary between nutrition and psychopharmacology
Thimerosal exposure in infants and neurodevelopmental disorders:
An assessment of computerized medical records in the
Vaccine Safety Datalink
Lithium Administration to Preadolescent Rats Causes
Long-Lasting Increases in Anxiety-Like Behavior and Has Molecular Consequences
Butylated Hydroxyanisole and Its Metabolite tert-Butylhydroquinone
Differentially Regulate Mitogen-activated Protein Kinases
Molecular Mechanisms of Butylated Hydroxylanisole-Induced Toxicity: Induction of Apoptosis through Direct Release of Cytochrome C
*BHA, preservative, cytotoxicity, Yu, Mandlekar, Kong
Neurotransmitter and Receptor Changes in the Brains of Fetuses From Areas of Endemic Fluorosis
The effects of exclusion of dietary egg and milk in the management of asthmatic children: a pilot study
Note: Eliminating milk and egg also eliminates most processed foods, thereby lowering the level of additives significantly. So - was it the milk, the egg, or the additives?
Osmophobia [intolerance to smell] in migraine and tension-type headache and its
clinical features in patients with migraine
Range of neurologic disorders in patients with celiac disease
Functional genomics of the dopaminergic system in hypertension
Review: Control of asthma
Vitamin E Inhibits Apoptosis, DNA Modification, and Cancer Incidence Induced by
Iron-mediated Peroxidation in Wistar Rat Kidney
The estrogenic potential of salicylate esters and their possible risks in foods and
cosmetics
*Flavors, fragrances, several salicylates are estrogen receptor agonists; estradiol equivalent concentrations; up to more than 3 times the ADI.
You Are How You Eat : Fast Food and Impatience
- just seeing the logo causes impatience etc. question: could it have to do with familiarity, and not context?
Separation-Induced Receptor Changes in the Hippocampus and Amygdala of Octodon degus: Influence of Maternal Vocalizations
Profile of Patients with Chemical Injury and Sensitivity
* migraine, headache, fibromyalgia, fatigue, pain, respiratory, adhd, tremor, seizures, mitral valve prolapse. causes: gasoline, kerosens, gas, pesticides, solvents, carpet, glue, fiberglass, copy paper, fabric softener, formaldehyde, carpet shampoo (lauryl sulfate, anesthesia. Porphyrin disturbance
The Effects of Acute Tryptophan Depletion on Reactive Aggression in Adults with Attention-Deficit/Hyperactivity Disorder (ADHD) and Healthy Controls
*adhd, tryptophan, aggression, neurotransmitter, Zimmermann, Grabemann, Mette, Abdel-Hamid, Ueckermann, Kraemer, Wiltfang, Kis, Zepf
Migraine and Tension-Type Headache in Croatia: A Population-Based Survey of Precipitating Factors
Allergic potential of food additives: A report of a case of tartrazine sensitivity without aspirin intolerance
*early study, urticaria, tartrazine, yellow 5, food dyes, Zlotlow, Settipane
Age, Academic Performance, and Stimulant Prescribing for ADHD: A Nationwide Cohort Study
* "Children in the youngest third of class were 50% more likely than those in the oldest third to be prescribed stimulants ..."
* It is recommended doctors take age into account to avoid unnecessary stimulant treatment. Zoega, Valdimarsdottir, Hernandez-Diaz. Iceland, US
Tourette Syndrome and Excitatory Substances: is There a Connection?
*TS, urine, food, children, tic disorders, testosterone, ephedrine, no real results, used adult tests, "relationship needs to be explored," Zou, Wang, Zhang, Zhao, Lu, Liu, Wang. China.
High response rate to additive-free diet in chronic urticaria
*Correspondence re findings of Greaves & O'Donnell 1995 and Smith & Burton 1994
Aromatic components of food as novel eliciting factors of pseudoallergic reactions in chronic urticaria
*allergy, eczema, skin, urticaria, food additives, salicylates, histamine, Zuberbier, Pfrommer, Specht, Vieths, Bastl-Borrmann, Worm, Henz, Germany
An Integrative Approach to Depression: Part 2--Assessment and Treatment
The Role of Nutrition in Mental Health: Attention Deficit Hyperactivity Disorder (ADHD)
* children, adults, adhd, diet. Zukier, Solomon, Hamadeh. Canada
Safety and Efficacy of Galactogogues: Substances that Induce, Maintain and Increase Breast Milk Production
*Breastfeeding, nursing, Zuppa, Sindico, Orchi, Carducci, Cardiello, Romagnoli, Catenazzi, Italy